| URN | urn:agi-llid:2110 |
|---|---|
| Connectivity | 9 |
| Name | Etfdh |
| Description | electron-transferring-flavoprotein dehydrogenase |
| Notes | Electron-transferring-flavoprotein dehydrogenase in the inner mitochondrial membrane accepts electrons from electron-transfer flavoprotein which is located in the mitochondrial matrix and reduces ubiquinone in the mitochondrial membrane. The protein is synthesized as a 67-kDa precursor which is targeted to mitochondria and processed in a single step to a 64-kDa mature form located in the mitochondrial membrane. Deficiency in electron-transferring-flavoprotein dehydrogenase have been demonstrated in some patients with type II glutaricacidemia. |
| Pathway | fatty acid beta degradation pathway |
|---|
| GO Molecular Function | electron carrier activity |
|---|---|
| oxidoreductase activity | |
| iron-sulfur cluster binding | |
| quinone binding | |
| FAD binding | |
| ubiquinone binding | |
| metal ion binding | |
| iron ion binding | |
| 4 iron, 4 sulfur cluster binding | |
| oxidoreductase activity, oxidizing metal ions with flavin as acceptor | |
| electron-transferring-flavoprotein dehydrogenase activity |
| GO Cellular Component | membrane |
|---|---|
| mitochondrion | |
| mitochondrial inner membrane | |
| mitochondrial electron transfer flavoprotein complex | |
| mitochondrial membrane | |
| integral to mitochondrial inner membrane |
| GO Biological Process | oxidation reduction |
|---|---|
| transport | |
| electron transport chain | |
| fatty acid beta-oxidation using acyl-CoA dehydrogenase | |
| response to oxidative stress |
| Ariadne Ontology | Respiratory chain |
|---|
| Group | Respiratory chain |
|---|---|
| electron carrier activity | |
| oxidation reduction | |
| transport | |
| electron transport chain | |
| fatty acid beta-oxidation using acyl-CoA dehydrogenase | |
| response to oxidative stress | |
| oxidoreductase activity | |
| iron-sulfur cluster binding | |
| quinone binding | |
| FAD binding | |
| ubiquinone binding | |
| metal ion binding | |
| iron ion binding | |
| 4 iron, 4 sulfur cluster binding | |
| oxidoreductase activity, oxidizing metal ions with flavin as acceptor | |
| electron-transferring-flavoprotein dehydrogenase activity | |
| membrane | |
| mitochondrion | |
| mitochondrial inner membrane | |
| mitochondrial electron transfer flavoprotein complex | |
| mitochondrial membrane | |
| integral to mitochondrial inner membrane |
| MedScan ID | 2110 |
|---|
| Hugo ID | 3483 |
|---|
| Human chromosome position | 4q32-q35 |
|---|
| LocusLink ID | 2110 |
|---|---|
| 66841 | |
| 295143 |
| Alias | MADD |
|---|---|
| ETFQO | |
| electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | |
| ETF-QO | |
| ETF dehydrogenase | |
| OTTHUMP00000220838 | |
| ETF-ubiquinone oxidoreductase | |
| electron transfer flavoprotein ubiquinone oxidoreductase | |
| AV001013 | |
| 0610010I20Rik | |
| OTTMUSP00000037609 | |
| electron-transferring-flavoprotein dehydrogenase | |
| MGC93785 | |
| 0610010I20 | |
| electron transfer flavoprotein dehydrogenase | |
| electron transfer flavoprotein dehydrogenases | |
| electron transfer flavoprotein Q oxidoreductase | |
| electron transfer flavoprotein Q oxidoreductases | |
| electron transfer flavoprotein reductase | |
| electron transfer flavoprotein reductases | |
| electron transferring flavoprotein, dehydrogenase | |
| ETFDH | |
| Electron transfer flavoprotein:ubiquinone oxidoreductase | |
| electron transfer flavoprotein-ubiquinone oxidoreductase | |
| RIKEN cDNA 0610010I20 gene | |
| ETF dehydrogenase |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 231675 |
|---|---|
| 231680 |
| Mouse chromosome position | 3 31.8 cM |
|---|
| GO ID | 0051539 |
|---|---|
| 0050660 | |
| 0009055 | |
| 0004174 | |
| 0046872 | |
| 0016491 | |
| 0043783 | |
| 0048038 | |
| 0048039 | |
| 0022900 | |
| 0033539 | |
| 0006979 | |
| 0006810 | |
| 0031305 | |
| 0016020 | |
| 0005743 | |
| 0031966 | |
| 0005739 | |
| 0051536 | |
| 0055114 | |
| 0017133 | |
| 0005506 | |
| 0016021 | |
| 0003674 | |
| 0008150 | |
| 0005575 | |
| 0009054 | |
| 0005624 |
| Rat chromosome position | 2q32 |
|---|
| Swiss-Prot Accession | Q16134 |
|---|---|
| Q547S8 | |
| Q921G7 | |
| Q6PF96 | |
| Q66HF3 | |
| Q6UPE1 | |
| Q3U7K2 | |
| Q8BK82 | |
| Q9DCT9 | |
| Q7Z347 | |
| AAB24227 |
| PIR ID | S41115 |
|---|
| Unigene ID | Hs.155729 |
|---|---|
| Mm.28336 | |
| Rn.37277 |
| KEGG ID | hsa:2110 |
|---|---|
| mmu:66841 | |
| rno:295143 |
| EC Number | 1.5.5.1 |
|---|
| Swiss-Prot ID | ETFD_MOUSE |
|---|---|
| ETFD_HUMAN | |
| Q66HF3_RAT |
| Cell Localization | Mitochondrion inner membrane |
|---|---|
| Mitochondria |
| IPI ID | IPI00121322 |
|---|---|
| IPI00032875 | |
| IPI00471868 | |
| IPI00455179 | |
| IPI00882287 | |
| IPI00395281 |
| Homologene ID | 3275 |
|---|
| RGD ID | 735052 |
|---|
| MGI ID | 106100 |
|---|