| URN | urn:agi-llid:2108 |
|---|---|
| Connectivity | 7 |
| Name | Etfa |
| Description | electron-transfer-flavoprotein, alpha polypeptide (glutaric aciduria II) |
| Notes | ETFA participates in catalyzing the initial step of the mitochondrial fatty acid beta-oxidation. It shuttles electrons between primary flavoprotein dehydrogenases and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. Defects in electron-transfer-flavoprotein have been implicated in type II glutaricaciduria in which multiple acyl-CoA dehydrogenase deficiencies result in large excretion of glutaric, lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids. |
| Pathway | fatty acid beta degradation pathway |
|---|
| GO Molecular Function | electron carrier activity |
|---|---|
| oxidoreductase activity | |
| FAD binding |
| GO Cellular Component | mitochondrion |
|---|---|
| mitochondrial electron transfer flavoprotein complex | |
| mitochondrial matrix |
| GO Biological Process | transport |
|---|---|
| electron transport chain |
| Ariadne Ontology | Respiratory chain |
|---|
| Group | Respiratory chain |
|---|---|
| electron carrier activity | |
| transport | |
| electron transport chain | |
| oxidoreductase activity | |
| FAD binding | |
| mitochondrion | |
| mitochondrial electron transfer flavoprotein complex | |
| mitochondrial matrix |
| MedScan ID | 2108 |
|---|
| Hugo ID | 3481 |
|---|
| Human chromosome position | 15q23-q25 |
|---|
| LocusLink ID | 2108 |
|---|---|
| 110842 | |
| 300726 |
| Alias | EMA |
|---|---|
| GA2 | |
| MADD | |
| electron transfer flavoprotein subunit alpha, mitochondrial | |
| alpha-ETF | |
| glutaric aciduria II | |
| electron transfer flavoprotein alpha-subunit | |
| electron transfer flavoprotein, alpha polypeptide | |
| D9Ertd394e | |
| 2010200I21Rik | |
| ETF | |
| electron transferring flavoprotein, alpha polypeptide | |
| 2010200I21 | |
| DNA segment, Chr 9, ERATO Doi 394, expressed | |
| Electron transfer flavoprotein alpha-subunit, mitochondrial | |
| electron-transfer-flavoprotein, alpha polypeptide (glutaric aciduria II) | |
| ETFA | |
| ETFA_HUMAN | |
| glutaric aciduria II gene | |
| glutaric aciduria II protein | |
| LOC235393 | |
| electron-transfer-flavoprotein, alpha polypeptide | |
| Electron transfer flavoprotein alpha-subunit, mitochondrial precursor | |
| electron-transferring-flavoprotein, alpha polypeptide | |
| electron-transferring-flavoprotein, alpha polypeptide (glutaric aciduria II) | |
| Doi 394 | |
| Doi 394s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 608053 |
|---|---|
| 231680 |
| Mouse chromosome position | 9 |
|---|---|
| 9 B |
| GO ID | 0050660 |
|---|---|
| 0009055 | |
| 0016491 | |
| 0022900 | |
| 0006810 | |
| 0005759 | |
| 0005739 | |
| 0017133 | |
| 0008150 | |
| 0005575 |
| Rat chromosome position | 8q24 |
|---|
| Swiss-Prot Accession | P13804 |
|---|---|
| Q53XN3 | |
| B4DT43 | |
| B1B1B4 | |
| Q99LC5 | |
| P13803 | |
| Q3THD7 | |
| Q3V000 | |
| Q4V9X5 | |
| Q8BMD3 | |
| Q8BMU7 | |
| Q5M7W0 |
| PIR ID | A31998 |
|---|---|
| A31568 |
| Unigene ID | Hs.39925 |
|---|---|
| Mm.290853 | |
| Rn.32496 |
| KEGG ID | hsa:2108 |
|---|---|
| mmu:110842 | |
| rno:300726 |
| Swiss-Prot ID | ETFA_MOUSE |
|---|---|
| ETFA_HUMAN | |
| ETFA_RAT | |
| Q53XN3_HUMAN | |
| B1B1B4_MOUSE | |
| B4DT43_HUMAN |
| Cell Localization | Mitochondrion matrix |
|---|---|
| Mitochondria |
| IPI ID | IPI00116753 |
|---|---|
| IPI00010810 | |
| IPI00205332 | |
| IPI00895865 | |
| IPI00792673 |
| Homologene ID | 100 |
|---|
| RGD ID | 628747 |
|---|
| MGI ID | 106092 |
|---|