| URN | urn:agi-llid:79001 |
|---|---|
| Total Entities | 0 |
| Connectivity | 229 |
| Name | Vkorc1 |
| Description | vitamin K epoxide reductase complex, subunit 1 |
| Notes | Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. Two pseudogenes have been identified on chromosome 1 and the X chromosome. Two alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | oxidoreductase activity |
|---|---|
| vitamin-K-epoxide reductase (warfarin-sensitive) activity | |
| vitamin-K-epoxide reductase (warfarin-insensitive) activity |
| GO Cellular Component | membrane |
|---|---|
| integral component of membrane | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| intracellular membrane-bounded organelle |
| GO Biological Process | oxidation-reduction process |
|---|---|
| vitamin K biosynthetic process | |
| vitamin K metabolic process | |
| positive regulation of coagulation | |
| regulation of blood coagulation | |
| response to organonitrogen compound | |
| response to organic cyclic compound | |
| response to antibiotic | |
| drug metabolic process | |
| cellular protein metabolic process | |
| post-translational protein modification | |
| peptidyl-glutamic acid carboxylation |
| Pathway | Coagulation Cascade |
|---|---|
| vitamin K cycle pathway | |
| warfarin pharmacodynamics pathway |
| Group | oxidation-reduction process |
|---|---|
| vitamin K biosynthetic process | |
| oxidoreductase activity | |
| vitamin-K-epoxide reductase (warfarin-sensitive) activity | |
| vitamin-K-epoxide reductase (warfarin-insensitive) activity | |
| vitamin K metabolic process | |
| positive regulation of coagulation | |
| regulation of blood coagulation | |
| response to organonitrogen compound | |
| response to organic cyclic compound | |
| response to antibiotic | |
| drug metabolic process | |
| cellular protein metabolic process | |
| post-translational protein modification | |
| peptidyl-glutamic acid carboxylation | |
| membrane | |
| integral component of membrane | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| intracellular membrane-bounded organelle | |
| Secreted proteins |
| LocusLink ID | 79001 |
|---|---|
| 27973 | |
| 309004 |
| Cell Localization | Endoplasmic reticulum membrane |
|---|
| GO ID | 0047057 |
|---|---|
| 0044267 | |
| 0017144 | |
| 0017187 | |
| 0043687 | |
| 0005789 | |
| 0016021 | |
| 0016491 | |
| 0047058 | |
| 0055114 | |
| 0050820 | |
| 0030193 | |
| 0046677 | |
| 0014070 | |
| 0010243 | |
| 0042371 | |
| 0042373 | |
| 0005783 | |
| 0043231 | |
| 0016020 |
| Alias | VKOR |
|---|---|
| MST134 | |
| MST576 | |
| VKCFD2 | |
| EDTP308 | |
| IMAGE3455200 | |
| MSTP134 | |
| vitamin K epoxide reductase complex subunit 1 | |
| phylloquinone epoxide reductase | |
| vitamin K1 2,3-epoxide reductase subunit 1 | |
| vitamin K dependent clotting factors deficiency 2 | |
| vitamin K1 epoxide reductase (warfarin-sensitive) | |
| D7Wsu86e | |
| Warfarin resistance | |
| VKORC1 | |
| vitamin k dependent clotting factors deficiency II | |
| vitamin k1 epoxide reductase | |
| vitamin k epoxide reductase complex | |
| vitamin K epoxide reductase complex, subunit 1 | |
| vitamin K epoxide reductase complex, subunit I | |
| vitamin k-dependent clotting factors | |
| vitamin k-dependent clotting factors, combined deficiency of, 2 | |
| vitamin k-dependent clotting factors, combined deficiency of, II | |
| BC039632 | |
| cDNA sequence BC039632 | |
| Tryptase gamma precursor (Transmembrane tryptase) | |
| FLJ00289 | |
| LOC330657 | |
| mflj00289 | |
| MGC2694 | |
| OTTMUSP00000040670 | |
| UNQ308 | |
| 2310024K08 |
| Mouse chromosome position | 7 69.81 cM |
|---|
| OMIM ID | 608547 |
|---|---|
| 607473 | |
| 122700 |
| Rat chromosome position | 1q36 |
|---|
| Hugo ID | 23663 |
|---|
| Human chromosome position | 16p11.2 |
|---|
| Swiss-Prot Accession | Q9BQB6 |
|---|---|
| Q9CRC0 | |
| B2GUU6 | |
| Q6TEK4 | |
| A6NIQ6 | |
| B2R4Z6 | |
| Q6UX90 | |
| Q7Z2R4 |
| Unigene ID | Hs.324844 |
|---|---|
| Mm.29703 | |
| Rn.97942 |
| KEGG ID | hsa:79001 |
|---|---|
| mmu:27973 | |
| rno:309004 |
| Swiss-Prot ID | VKOR1_HUMAN |
|---|---|
| VKOR1_RAT | |
| VKOR1_MOUSE |
| EC Number | 1.1.4.1 |
|---|
| Ensembl ID | ENSG00000167397 |
|---|---|
| ENSP00000378426 | |
| ENST00000394975 | |
| ENSP00000346969 | |
| ENST00000354895 | |
| ENSP00000326135 | |
| ENST00000319788 | |
| ENSMUSG00000096145 | |
| ENSMUSP00000033074 | |
| ENSMUST00000033074 | |
| ENSRNOG00000050828 | |
| ENSRNOP00000063977 | |
| ENSRNOT00000073596 |
| Homologene ID | 11416 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 106442 |
|---|
| RGD ID | 1303107 |
|---|
| MedScan ID | 79001 |
|---|