| URN | urn:agi-llid:1543 |
|---|---|
| Total Entities | 0 |
| Connectivity | 2015 |
| Name | CYP1A1 |
| Description | cytochrome P450, family 1, subfamily A, polypeptide 1 |
| Notes | This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | oxidoreductase activity |
|---|---|
| oxidoreductase activity, acting on diphenols and related substances as donors | |
| monooxygenase activity | |
| vitamin D 24-hydroxylase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | |
| flavonoid 3'-monooxygenase activity | |
| aromatase activity | |
| steroid hydroxylase activity | |
| demethylase activity | |
| catalytic activity | |
| oxygen binding | |
| enzyme binding | |
| heme binding | |
| metal ion binding | |
| iron ion binding |
| GO Cellular Component | membrane |
|---|---|
| endoplasmic reticulum membrane | |
| mitochondrial membrane | |
| cytoplasm | |
| endoplasmic reticulum | |
| mitochondrion | |
| intracellular membrane-bounded organelle |
| GO Biological Process | developmental process |
|---|---|
| maternal process involved in parturition | |
| cell proliferation | |
| small molecule metabolic process | |
| oxidation-reduction process | |
| demethylation | |
| 9-cis-retinoic acid biosynthetic process | |
| dibenzo-p-dioxin catabolic process | |
| cellular lipid metabolic process | |
| arachidonic acid metabolic process | |
| omega-hydroxylase P450 pathway | |
| epoxygenase P450 pathway | |
| vitamin D metabolic process | |
| dibenzo-p-dioxin metabolic process | |
| toxin metabolic process | |
| insecticide metabolic process | |
| coumarin metabolic process | |
| liver development | |
| camera-type eye development | |
| hepatocyte differentiation | |
| digestive tract development | |
| embryo development ending in birth or egg hatching | |
| aging | |
| positive regulation of G1-S transition of mitotic cell cycle | |
| response to toxic substance | |
| response to food | |
| response to drug | |
| response to organic substance | |
| response to arsenic-containing substance | |
| response to lipopolysaccharide | |
| response to iron(III) ion | |
| xenobiotic metabolic process | |
| response to organic cyclic compound | |
| response to vitamin A | |
| response to antibiotic | |
| response to herbicide | |
| response to hypoxia | |
| response to wounding | |
| response to hyperoxia | |
| response to immobilization stress | |
| response to nematode | |
| response to virus | |
| heterocycle metabolic process | |
| drug metabolic process | |
| porphyrin-containing compound metabolic process | |
| hydrogen peroxide biosynthetic process | |
| flavonoid metabolic process | |
| amine metabolic process |
| Pathway | Proteins Involved in Pathogenesis of Cystic Fibrosis |
|---|---|
| Proteins Involved in Pathogenesis of Polycystic Ovary Syndrome | |
| Metabolism of estrogens and androgens | |
| Vitamin A (retinol) metabolism and visual cycle | |
| warfarin pharmacokinetics pathway |
| Group | Aromatic amino acid metabolism |
|---|---|
| developmental process | |
| maternal process involved in parturition | |
| cell proliferation | |
| small molecule metabolic process | |
| oxidation-reduction process | |
| demethylation | |
| 9-cis-retinoic acid biosynthetic process | |
| dibenzo-p-dioxin catabolic process | |
| oxidoreductase activity | |
| oxidoreductase activity, acting on diphenols and related substances as donors | |
| monooxygenase activity | |
| vitamin D 24-hydroxylase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | |
| flavonoid 3'-monooxygenase activity | |
| aromatase activity | |
| steroid hydroxylase activity | |
| cellular lipid metabolic process | |
| arachidonic acid metabolic process | |
| omega-hydroxylase P450 pathway | |
| epoxygenase P450 pathway | |
| vitamin D metabolic process | |
| dibenzo-p-dioxin metabolic process | |
| demethylase activity | |
| toxin metabolic process | |
| insecticide metabolic process | |
| coumarin metabolic process | |
| liver development | |
| camera-type eye development | |
| hepatocyte differentiation | |
| digestive tract development | |
| embryo development ending in birth or egg hatching | |
| aging | |
| positive regulation of G1-S transition of mitotic cell cycle | |
| response to toxic substance | |
| response to food | |
| response to drug | |
| response to organic substance | |
| response to arsenic-containing substance | |
| response to lipopolysaccharide | |
| response to iron(III) ion | |
| xenobiotic metabolic process | |
| response to organic cyclic compound | |
| response to vitamin A | |
| response to antibiotic | |
| response to herbicide | |
| response to hypoxia | |
| response to wounding | |
| response to hyperoxia | |
| response to immobilization stress | |
| response to nematode | |
| response to virus | |
| catalytic activity | |
| heterocycle metabolic process | |
| drug metabolic process | |
| porphyrin-containing compound metabolic process | |
| hydrogen peroxide biosynthetic process | |
| flavonoid metabolic process | |
| amine metabolic process | |
| oxygen binding | |
| enzyme binding | |
| heme binding | |
| metal ion binding | |
| iron ion binding | |
| membrane | |
| endoplasmic reticulum membrane | |
| mitochondrial membrane | |
| cytoplasm | |
| endoplasmic reticulum | |
| mitochondrion | |
| intracellular membrane-bounded organelle | |
| Genes Associated with Systemic Lupus Erythematosus | |
| Secreted proteins |
| LocusLink ID | 1543 |
|---|---|
| 13076 | |
| 24296 |
| Cell Localization | Cytoplasm |
|---|---|
| Endoplasmic reticulum membrane | |
| Microsome membrane | |
| Mitochondrion membrane | |
| Endoplasmic reticulum | |
| Mitochondrion |
| GO ID | 0070330 |
|---|---|
| 0032451 | |
| 0019899 | |
| 0016711 | |
| 0020037 | |
| 0005506 | |
| 0016491 | |
| 0016679 | |
| 0019825 | |
| 0008395 | |
| 0070576 | |
| 0042904 | |
| 0007568 | |
| 0009308 | |
| 0019369 | |
| 0043010 | |
| 0008283 | |
| 0044255 | |
| 0009804 | |
| 0019341 | |
| 0048565 | |
| 0017144 | |
| 0009792 | |
| 0019373 | |
| 0009812 | |
| 0070365 | |
| 0050665 | |
| 0017143 | |
| 0060137 | |
| 0097267 | |
| 0055114 | |
| 0006778 | |
| 0046677 | |
| 0046685 | |
| 0042493 | |
| 0032094 | |
| 0009635 | |
| 0055093 | |
| 0001666 | |
| 0010041 | |
| 0032496 | |
| 0009624 | |
| 0014070 | |
| 0009615 | |
| 0033189 | |
| 0009611 | |
| 0044281 | |
| 0042359 | |
| 0006805 | |
| 0005789 | |
| 0005739 | |
| 0003824 | |
| 0046872 | |
| 0004497 | |
| 0016705 | |
| 0016712 | |
| 0070988 | |
| 0018894 | |
| 0046483 | |
| 1900087 | |
| 0009636 | |
| 0009404 | |
| 0005737 | |
| 0005783 | |
| 0043231 | |
| 0016020 | |
| 0032502 | |
| 0001889 | |
| 0035902 | |
| 0010033 | |
| 0031966 |
| Alias | AHH |
|---|---|
| AHRR | |
| CP11 | |
| CYP1 | |
| P1-450 | |
| P450-C | |
| P450DX | |
| cytochrome P450 1A1 | |
| CYPIA1 | |
| cytochrome P450-C | |
| cytochrome P450-P1 | |
| cytochrome P450 form 6 | |
| xenobiotic monooxygenase | |
| aryl hydrocarbon hydroxylase | |
| flavoprotein-linked monooxygenase | |
| cytochrome P1-450, dioxin-inducible | |
| cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1 | |
| Cyp1a2 | |
| P450-1 | |
| aromatic compound inducible | |
| cytochrome P450 subfamily I, polypeptide 1 | |
| cytochrome P450, 1a1, aromatic compound inducible | |
| cytochrome P450 family 1 subfamily a polypeptide 2 | |
| Cyp45c | |
| Cypc45c | |
| P-450MC | |
| P450MT2 | |
| P450form6 | |
| dioxin-inducible | |
| cytochrome P1-450 | |
| cytochrome P450MT2 | |
| cytochrome P450, 1a1 | |
| microsomal monooxygenase | |
| cytochrome P450 subfamily I (aromatic compound-inducible) member A1 (C6 form c) (C6 form c) | |
| cytochrome P450, subfamily I (aromatic compound-inducible), member A1 (C6, form c) (C6, form c) | |
| Cyp1a-1 | |
| P450 (CYP) VI | |
| P450 (CYP) 6 | |
| P450 (CYP) 45c | |
| P450 (CYP) 1A1 | |
| P450 1A1 | |
| P45045c | |
| OTTHUMP00000183469 | |
| P450 45c | |
| P450 6 | |
| P4501A1 | |
| P450-Cs | |
| P450-P I | |
| P450-P1 | |
| P450 VI | |
| CYP I | |
| cytochrome P45045c | |
| cytochrome P450 CYP1A1 | |
| Cyp1a I | |
| CYP1A1 | |
| CYPIA I | |
| cytochrome P450 I (aromatic compound-inducible) I | |
| cytochrome P450 I I | |
| cytochrome P450 I 1 | |
| cytochrome P450 I (aromatic compound-inducible) A1 | |
| cytochrome P450 I (aromatic compound-inducible) 1 | |
| cytochrome P450 45c | |
| cytochrome P450 1a1 aromatic compound inducible | |
| cytochrome P450 1A I |
| Mouse chromosome position | 9 31.34 cM |
|---|
| OMIM ID | 108330 |
|---|
| Rat chromosome position | 8q24 |
|---|
| Hugo ID | 2595 |
|---|
| Human chromosome position | 15q24.1 |
|---|
| Swiss-Prot Accession | A0N0X8 |
|---|---|
| P04798 | |
| Q5J9B1 | |
| E7EMT5 | |
| A4F4K4 | |
| P00184 | |
| Q05A20 | |
| P00185 | |
| A4F3V9 | |
| A4F3W0 | |
| Q53G18 | |
| Q61455 |
| PIR ID | A24797 |
|---|---|
| A23923 | |
| A00185 |
| Unigene ID | Hs.72912 |
|---|---|
| Mm.14089 | |
| Rn.10352 |
| KEGG ID | hsa:1543 |
|---|---|
| mmu:13076 | |
| rno:24296 |
| Swiss-Prot ID | CP1A1_HUMAN |
|---|---|
| CP1A1_MOUSE | |
| CP1A1_RAT |
| EC Number | 1.14.14.1 |
|---|
| Ensembl ID | ENSG00000140465 |
|---|---|
| ENSP00000378488 | |
| ENST00000395048 | |
| ENSP00000369050 | |
| ENST00000379727 | |
| ENSMUSG00000032315 | |
| ENSMUSP00000034865 | |
| ENSMUST00000034865 | |
| ENSRNOG00000019500 | |
| ENSRNOP00000026473 | |
| ENSRNOT00000026473 |
| Homologene ID | 68062 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 88588 |
|---|
| RGD ID | 730870 |
|---|
| MedScan ID | 1543 |
|---|