| URN | urn:agi-llid:1544 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1457 |
| Name | CYP1A2 |
| Description | cytochrome P450, family 1, subfamily A, polypeptide 2 |
| Notes | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | oxidoreductase activity |
|---|---|
| monooxygenase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | |
| aromatase activity | |
| caffeine oxidase activity | |
| demethylase activity | |
| electron carrier activity | |
| enzyme binding | |
| heme binding | |
| metal ion binding | |
| iron ion binding |
| GO Cellular Component | membrane |
|---|---|
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| intracellular membrane-bounded organelle |
| GO Biological Process | small molecule metabolic process |
|---|---|
| oxidation-reduction process | |
| toxin biosynthetic process | |
| steroid catabolic process | |
| oxidative deethylation | |
| oxidative demethylation | |
| cellular respiration | |
| arachidonic acid metabolic process | |
| omega-hydroxylase P450 pathway | |
| epoxygenase P450 pathway | |
| monoterpenoid metabolic process | |
| dibenzo-p-dioxin metabolic process | |
| monocarboxylic acid metabolic process | |
| toxin metabolic process | |
| post-embryonic development | |
| lung development | |
| response to stress | |
| response to drug | |
| response to organic substance | |
| response to lipopolysaccharide | |
| response to estradiol | |
| cellular response to cadmium ion | |
| xenobiotic metabolic process | |
| response to organic cyclic compound | |
| exogenous drug catabolic process | |
| response to immobilization stress | |
| regulation of gene expression | |
| methylation | |
| heterocycle metabolic process | |
| drug metabolic process | |
| cellular aromatic compound metabolic process | |
| porphyrin-containing compound metabolic process | |
| hydrogen peroxide biosynthetic process | |
| drug catabolic process | |
| alkaloid metabolic process |
| Pathway | Vitamin A (retinol) metabolism and visual cycle |
|---|---|
| Caffeine metabolism | |
| Clozapine-Induced Granulocytopenia | |
| warfarin pharmacokinetics pathway |
| Group | Aromatic amino acid metabolism |
|---|---|
| small molecule metabolic process | |
| oxidation-reduction process | |
| toxin biosynthetic process | |
| steroid catabolic process | |
| oxidative deethylation | |
| oxidative demethylation | |
| oxidoreductase activity | |
| monooxygenase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | |
| aromatase activity | |
| caffeine oxidase activity | |
| cellular respiration | |
| arachidonic acid metabolic process | |
| omega-hydroxylase P450 pathway | |
| epoxygenase P450 pathway | |
| monoterpenoid metabolic process | |
| dibenzo-p-dioxin metabolic process | |
| monocarboxylic acid metabolic process | |
| demethylase activity | |
| toxin metabolic process | |
| post-embryonic development | |
| lung development | |
| response to stress | |
| response to drug | |
| response to organic substance | |
| response to lipopolysaccharide | |
| response to estradiol | |
| cellular response to cadmium ion | |
| xenobiotic metabolic process | |
| response to organic cyclic compound | |
| exogenous drug catabolic process | |
| response to immobilization stress | |
| regulation of gene expression | |
| methylation | |
| heterocycle metabolic process | |
| drug metabolic process | |
| cellular aromatic compound metabolic process | |
| porphyrin-containing compound metabolic process | |
| hydrogen peroxide biosynthetic process | |
| drug catabolic process | |
| alkaloid metabolic process | |
| electron carrier activity | |
| enzyme binding | |
| heme binding | |
| metal ion binding | |
| iron ion binding | |
| membrane | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| intracellular membrane-bounded organelle | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 1544 |
|---|---|
| 13077 | |
| 24297 |
| Cell Localization | Cytoplasm |
|---|---|
| Endoplasmic reticulum membrane | |
| Microsome membrane |
| GO ID | 0070330 |
|---|---|
| 0034875 | |
| 0032451 | |
| 0009055 | |
| 0019899 | |
| 0020037 | |
| 0005506 | |
| 0004497 | |
| 0016491 | |
| 0016712 | |
| 0009820 | |
| 0019369 | |
| 0045333 | |
| 0071276 | |
| 0018894 | |
| 0042737 | |
| 0017144 | |
| 0019373 | |
| 0042738 | |
| 0046483 | |
| 0050665 | |
| 0030324 | |
| 0032259 | |
| 0032787 | |
| 0016098 | |
| 0097267 | |
| 0055114 | |
| 0071615 | |
| 0070989 | |
| 0006778 | |
| 0009791 | |
| 0010468 | |
| 0032355 | |
| 0032496 | |
| 0006950 | |
| 0044281 | |
| 0006706 | |
| 0009403 | |
| 0006805 | |
| 0005789 | |
| 0043231 | |
| 0046872 | |
| 0016705 | |
| 0006725 | |
| 0009404 | |
| 0005783 | |
| 0016020 | |
| 0042493 | |
| 0035902 | |
| 0014070 | |
| 0010033 |
| Alias | CP12 |
|---|---|
| P3-450 | |
| P450(PA) | |
| cytochrome P450 1A2 | |
| CYPIA2 | |
| P450 form 4 | |
| cytochrome P450 4 | |
| cytochrome P(3)450 | |
| cytochrome P450-P3 | |
| dioxin-inducible P3-450 | |
| microsomal monooxygenase | |
| xenobiotic monooxygenase | |
| aryl hydrocarbon hydroxylase | |
| flavoprotein-linked monooxygenase | |
| cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2 | |
| Cyp1a1 | |
| P450-3 | |
| cytochrome P450-P2 | |
| aromatic compound inducible | |
| cytochrome P450, 1a2, aromatic compound inducible | |
| cytochrome P450 family 1 subfamily a polypeptide 1 | |
| CYPD45 | |
| P-450d | |
| RATCYPD45 | |
| P-448 | |
| P450-D | |
| cytochrome P-448 | |
| cytochrome P-450d | |
| cytochrome P450-D | |
| cytochrome P450, 1a2 | |
| Cytochrome P450 subfamily I (aromatic compound-inducible) member A2 (Q42 form d) | |
| cytochrome P450, subfamily I (aromatic compound-inducible), member A2 (Q42, form d) | |
| Cyp1a-2 | |
| P450 IV | |
| P450 (CYP) 4 | |
| P450 (CYP) IV | |
| P450 1A2 | |
| P450 4 | |
| P450 (CYP) 1A2 | |
| P4501A2 | |
| P-450ds | |
| P450-P3 | |
| phenacetin O-deethylase | |
| cytochrome P450 1A2 aromatic compound inducible | |
| cytochrome P450 I (aromatic compound-inducible) 2 | |
| cytochrome P450 I (aromatic compound-inducible) A2 | |
| cytochrome P450 I (aromatic compound-inducible) II | |
| CYP1A2 |
| Mouse chromosome position | 9 31.3 cM |
|---|
| OMIM ID | 124060 |
|---|
| Rat chromosome position | 8q24 |
|---|
| Hugo ID | 2596 |
|---|
| Human chromosome position | 15q24.1 |
|---|
| Swiss-Prot Accession | P05177 |
|---|---|
| B6VGH4 | |
| P00186 | |
| P04799 | |
| Q9QWJ4 | |
| A1L120 | |
| Q64588 | |
| Q16754 | |
| Q6NWU5 | |
| Q9BXX7 | |
| Q9UK49 |
| PIR ID | B92495 |
|---|---|
| A61400 | |
| S16718 |
| Unigene ID | Hs.1361 |
|---|---|
| Mm.15537 | |
| Rn.5563 |
| KEGG ID | hsa:1544 |
|---|---|
| mmu:13077 | |
| rno:24297 |
| Swiss-Prot ID | CP1A2_MOUSE |
|---|---|
| CP1A2_RAT | |
| CP1A2_HUMAN |
| EC Number | 1.14.14.1 |
|---|
| Ensembl ID | ENSG00000140505 |
|---|---|
| ENSP00000342007 | |
| ENST00000343932 | |
| ENSMUSG00000032310 | |
| ENSMUSP00000034860 | |
| ENSMUST00000034860 | |
| ENSRNOG00000016173 | |
| ENSRNOP00000021653 | |
| ENSRNOT00000021653 |
| Homologene ID | 68082 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 88589 |
|---|
| RGD ID | 735711 |
|---|
| MedScan ID | 1544 |
|---|