| URN | urn:agi-llid:1575 |
|---|---|
| Total Entities | 0 |
| Connectivity | 2469 |
| Name | CYP3A4 |
| Description | cytochrome P450, family 3, subfamily A, polypeptide 4 |
| Notes | This gene, CYP3A4, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs which are are used today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. |
| GO Molecular Function | vitamin D3 25-hydroxylase activity |
|---|---|
| oxidoreductase activity | |
| monooxygenase activity | |
| vitamin D 24-hydroxylase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | |
| quinine 3-monooxygenase activity | |
| albendazole monooxygenase activity | |
| taurochenodeoxycholate 6alpha-hydroxylase activity | |
| aromatase activity | |
| steroid hydroxylase activity | |
| testosterone 6-beta-hydroxylase activity | |
| caffeine oxidase activity | |
| demethylase activity | |
| oxygen binding | |
| enzyme binding | |
| steroid binding | |
| heme binding | |
| iron ion binding |
| GO Cellular Component | integral component of membrane |
|---|---|
| endoplasmic reticulum membrane | |
| cytoplasm | |
| intracellular membrane-bounded organelle |
| GO Biological Process | lipid metabolic process |
|---|---|
| small molecule metabolic process | |
| oxidation-reduction process | |
| calcitriol biosynthetic process from calciol | |
| steroid catabolic process | |
| oxidative demethylation | |
| steroid metabolic process | |
| monoterpenoid metabolic process | |
| androgen metabolic process | |
| vitamin D metabolic process | |
| xenobiotic metabolic process | |
| exogenous drug catabolic process | |
| heterocycle metabolic process | |
| drug metabolic process | |
| alkaloid catabolic process | |
| drug catabolic process |
| Pathway | Vitamin A (retinol) metabolism and visual cycle |
|---|---|
| IL2 Expression Targets | |
| GH1-GHR/STAT Expression Targets | |
| GH1-PRLR Expression Targets | |
| nateglinide pharmacokinetics pathway | |
| repaglinide pharmacokinetics pathway | |
| statin pharmacokinetics pathway | |
| warfarin pharmacokinetics pathway |
| Group | Xenobiotic clearance |
|---|---|
| lipid metabolic process | |
| small molecule metabolic process | |
| oxidation-reduction process | |
| calcitriol biosynthetic process from calciol | |
| vitamin D3 25-hydroxylase activity | |
| steroid catabolic process | |
| oxidative demethylation | |
| oxidoreductase activity | |
| monooxygenase activity | |
| vitamin D 24-hydroxylase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | |
| quinine 3-monooxygenase activity | |
| albendazole monooxygenase activity | |
| taurochenodeoxycholate 6alpha-hydroxylase activity | |
| aromatase activity | |
| steroid hydroxylase activity | |
| testosterone 6-beta-hydroxylase activity | |
| caffeine oxidase activity | |
| steroid metabolic process | |
| monoterpenoid metabolic process | |
| androgen metabolic process | |
| vitamin D metabolic process | |
| demethylase activity | |
| xenobiotic metabolic process | |
| exogenous drug catabolic process | |
| heterocycle metabolic process | |
| drug metabolic process | |
| alkaloid catabolic process | |
| drug catabolic process | |
| oxygen binding | |
| enzyme binding | |
| steroid binding | |
| heme binding | |
| iron ion binding | |
| integral component of membrane | |
| endoplasmic reticulum membrane | |
| cytoplasm | |
| intracellular membrane-bounded organelle | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 1575 |
|---|---|
| 1576 | |
| 266682 | |
| 13112 | |
| 53973 | |
| 337924 | |
| 25642 |
| Cell Localization | Plasma membrane |
|---|---|
| Endoplasmic reticulum membrane | |
| Microsome membrane |
| GO ID | 0047638 |
|---|---|
| 0034875 | |
| 0019899 | |
| 0020037 | |
| 0005506 | |
| 0004497 | |
| 0016491 | |
| 0016712 | |
| 0019825 | |
| 0050591 | |
| 0005496 | |
| 0008395 | |
| 0033780 | |
| 0050649 | |
| 0070576 | |
| 0030343 | |
| 0009822 | |
| 0008209 | |
| 0036378 | |
| 0042737 | |
| 0017144 | |
| 0042738 | |
| 0046483 | |
| 0006629 | |
| 0016098 | |
| 0055114 | |
| 0070989 | |
| 0044281 | |
| 0006706 | |
| 0008202 | |
| 0042359 | |
| 0006805 | |
| 0005737 | |
| 0005789 | |
| 0016021 | |
| 0043231 | |
| 0070330 | |
| 0032451 | |
| 0009055 | |
| 0046872 | |
| 0009986 | |
| 0005783 | |
| 0016020 | |
| 0005624 | |
| 0005792 | |
| 0050381 | |
| 0005615 | |
| 0003674 | |
| 0008150 | |
| 0005575 | |
| 0007568 | |
| 0046686 | |
| 0042493 | |
| 0051384 | |
| 0010038 | |
| 0007584 |
| Alias | HLP |
|---|---|
| CP33 | |
| CP34 | |
| CYP3A | |
| NF-25 | |
| CYP3A3 | |
| P450C3 | |
| CYPIIIA3 | |
| CYPIIIA4 | |
| P450PCN1 | |
| cytochrome P450 3A4 | |
| nifedipine oxidase | |
| cytochrome P450 3A3 | |
| cytochrome P450 HLp | |
| cytochrome P450-PCN1 | |
| cytochrome P450 NF-25 | |
| albendazole sulfoxidase | |
| quinine 3-monooxygenase | |
| albendazole monooxygenase | |
| P450-III, steroid inducible | |
| glucocorticoid-inducible P450 | |
| 1,8-cineole 2-exo-monooxygenase | |
| taurochenodeoxycholate 6-alpha-hydroxylase | |
| cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3 | |
| cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4 | |
| Cyp3a11 | |
| cytochrome P450 3A2 | |
| CYPIIIA2 | |
| P450-PCN2 | |
| P450/6-beta-A | |
| cytochrome P450-PCN2 | |
| cytochrome P450/6-beta-A | |
| testosterone 6-beta-hydroxylase | |
| cytochrome P450, family 3, subfamily a, polypeptide 11 | |
| P450 (CYP) 3a23/3a1 | |
| olfactory cytochrome P450olf3 | |
| OTTMUSP00000030400 | |
| OTTMUSP00000031951 | |
| P450 (CYP) 3a11 | |
| P450 (CYP) 3a16 | |
| P450 (CYP) 3a2 | |
| P450 (CYP) 3A4 | |
| P450 (CYP) 3a23/1 | |
| P450 (CYP) 3A3 | |
| mKIAA3002 | |
| P450 (CYP) 3A21 | |
| MGC93139 | |
| MGC126680 | |
| MGC108757 | |
| IIIAm2 | |
| IIIAm1 | |
| IIIAm I | |
| P450 (CYP) 3a41 | |
| FLJ11220 | |
| P450 3a23/1 | |
| E330004N01 | |
| cytochrome P-450UT | |
| cytochrome P-450IIIAM1 | |
| P450 3a41b | |
| P4503a44 | |
| P4503a41a | |
| P4503A4 | |
| P4503A3 | |
| P4503a23/3a1 | |
| P4503a23/1 | |
| P4503A21 | |
| P4503a2 | |
| P4503a16 | |
| P4503a11 | |
| P450 3a2 | |
| cytochrome P4503a11 | |
| P450 (CYP) 3a41b | |
| P450 (CYP) 3a44 | |
| P450 (CYP) IIIa | |
| P450 3a11 | |
| P450 3a16 | |
| P450 IIIa | |
| P450 3A21 | |
| P450 3a44 | |
| P450 3a23/3a1 | |
| P450 3A3 | |
| P450 3A4 | |
| P450 3a41 | |
| P450 3a41a | |
| P450 (CYP) 3a41a | |
| cytochrome P4503a44 | |
| CYP3A4 | |
| cytochrome P450 3a16 | |
| cytochrome P450 3a11 | |
| CYPSA4 | |
| CYPIIIA16 | |
| CYPIIIA11 | |
| CYPIIIA1 | |
| Cyp3a44 | |
| Cyp3a41b | |
| cytochrome P4503a2 | |
| Cyp3a41 | |
| cytochrome P450 3a23/3a1 | |
| Cyp3a23/3a1 | |
| Cyp3a23 | |
| Cyp3a21 | |
| CYP3a2 | |
| Cyp3a16 | |
| cdex | |
| C230004D03 | |
| AI256190 | |
| P4503a41b | |
| P450olf3 | |
| Cyp3a41a | |
| cytochrome P450 IIIA niphedipine oxidase IV | |
| cytochrome P4503a41a | |
| cytochrome P4503a41 | |
| cytochrome P4503A4 | |
| cytochrome P4503A3 | |
| cytochrome P4503a23/3a1 | |
| cytochrome P4503a23/1 | |
| cytochrome P4503A21 | |
| cytochrome P4503a16 | |
| cytochrome P450/6 beta B | |
| cytochrome p450, steroid inducible 3a41 | |
| cytochrome P450, steroid inducible 3a11 | |
| cytochrome P450 3A21 | |
| cytochrome P4503a41b | |
| cytochrome P450 3a41 | |
| cytochrome P450 3a41a | |
| cytochrome P450 IIIA4 | |
| cytochrome P450 3a44 | |
| cytochrome P450 IIIA3 | |
| cytochrome P450 IIIA III | |
| cytochrome P450 IIIA IV | |
| cytochrome P450 IIIA niphedipine oxidase 3 | |
| cytochrome P450 IIIA niphedipine oxidase 4 | |
| cytochrome P450 IIIA niphedipine oxidase III | |
| cytochrome P450 3a23/1 | |
| cytochrome P450 3a41b | |
| P4503a41 | |
| RL33 | |
| P450PCN I | |
| RL(33) | |
| cytochrome P450, subfamily IIIA, polypeptide 4 | |
| Pcn | |
| steroid inducible | |
| cytochrome P450, family 3, subfamily a, polypeptide 41A | |
| cytochrome P450, family 3, subfamily a, polypeptide 41 | |
| cytochrome P450, family 3, subfamily a, polypeptide 44 | |
| cytochrome P450, 3a44 | |
| CYP | |
| Cyp3a1 | |
| cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1 | |
| cytochrome P-450PCN (PNCN inducible) | |
| cytochrome P450, subfamily 3A, polypeptide 3 | |
| Cytochrome P450, subfamily IIIA, polypeptide 3 | |
| cytochrome P450, family 3, subfamily a, polypeptide 1 | |
| CYP3A9 | |
| cytochrome P450, family 3, subfamily a, polypeptide 13 | |
| 8430412F05 | |
| hypothetical protein 8430412F05 | |
| hypothetical protein FLJ11220 | |
| RIKEN cDNA C230004D03 gene | |
| cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide IV | |
| Cytochrome P450 3A21 (CYPIIIA21) (P450 CM3A-10) | |
| cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide III | |
| Cytochrome P450, subfamily IIIA, polypeptide III | |
| Cyp3a13 | |
| cytochrome P450, family 3, subfamily a, polypeptide 16 | |
| C230004D03Rik | |
| cytochrome P450 3A9 | |
| cytochrome P450, subfamily IIIA, polypeptide IV | |
| IIIAm2s | |
| RL 33 | |
| RL-33 |
| Mouse chromosome position | 5 85.0 cM |
|---|
| OMIM ID | 124010 |
|---|
| Rat chromosome position | 12p11 |
|---|
| Hugo ID | 2637 |
|---|
| Human chromosome position | 7q21.1 |
|---|
| Swiss-Prot Accession | P08684 |
|---|---|
| Q6GRK0 | |
| P05183 | |
| Q5FVU5 | |
| Q64629 | |
| Q64672 | |
| P05184 | |
| Q16757 | |
| Q9UK50 |
| PIR ID | A25222 |
|---|---|
| A29410 | |
| A29815 |
| Unigene ID | Hs.728751 |
|---|---|
| Rn.225885 | |
| Hs.654391 | |
| Mm.332844 | |
| Mm.379071 | |
| Mm.425301 | |
| Rn.91120 |
| KEGG ID | hsa:1576 |
|---|---|
| rno:266682 | |
| mmu:13112 | |
| mmu:53973 | |
| mmu:337924 | |
| rno:25642 |
| Swiss-Prot ID | CP3A2_RAT |
|---|---|
| CP3A4_HUMAN |
| EC Number | 1.14.13.157 |
|---|---|
| 1.14.13.32 | |
| 1.14.13.67 | |
| 1.14.13.97 | |
| 1.14.14.1 | |
| 1.14.13.- |
| Homologene ID | 111391 |
|---|
| Organism | Homo sapiens |
|---|---|
| Rattus norvegicus | |
| Mus musculus |
| MGI ID | 88609 |
|---|---|
| 1858451 | |
| 2449818 |
| RGD ID | 1352962 |
|---|
| MedScan ID | 1575 |
|---|