| URN | urn:agi-llid:1561 |
|---|---|
| Total Entities | 0 |
| Connectivity | 153 |
| Name | CYP2C18 |
| Description | cytochrome P450, family 2, subfamily C, polypeptide 18 |
| Notes | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | oxidoreductase activity |
|---|---|
| monooxygenase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | |
| aromatase activity | |
| oxygen binding | |
| heme binding | |
| metal ion binding | |
| iron ion binding |
| GO Cellular Component | membrane |
|---|---|
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| intracellular membrane-bounded organelle |
| GO Biological Process | small molecule metabolic process |
|---|---|
| oxidation-reduction process | |
| response to drug | |
| xenobiotic metabolic process | |
| drug metabolic process |
| Pathway | Arachidonic acid metabolism |
|---|---|
| GH1-GHR/NF-kB/ELK-SRF/MYC Expression Targets | |
| GH1-GHR/STAT Expression Targets | |
| GH1-PRLR Expression Targets | |
| warfarin pharmacokinetics pathway |
| Group | Leukotriene synthesis |
|---|---|
| small molecule metabolic process | |
| oxidation-reduction process | |
| oxidoreductase activity | |
| monooxygenase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | |
| aromatase activity | |
| response to drug | |
| xenobiotic metabolic process | |
| drug metabolic process | |
| oxygen binding | |
| heme binding | |
| metal ion binding | |
| iron ion binding | |
| membrane | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| intracellular membrane-bounded organelle |
| LocusLink ID | 1561 |
|---|---|
| 1562 | |
| 13096 | |
| 107141 | |
| 404195 | |
| 29296 | |
| 293989 |
| Cell Localization | Plasma membrane |
|---|---|
| Endoplasmic reticulum membrane | |
| Microsome membrane |
| GO ID | 0070330 |
|---|---|
| 0020037 | |
| 0005506 | |
| 0004497 | |
| 0019825 | |
| 0044281 | |
| 0006805 | |
| 0005789 | |
| 0046872 | |
| 0016491 | |
| 0016705 | |
| 0055114 | |
| 0005783 | |
| 0043231 | |
| 0016020 | |
| 0017144 | |
| 0042493 |
| Alias | CPCI |
|---|---|
| CYP2C | |
| CYP2C17 | |
| P450IIC17 | |
| P450-6B/29C | |
| RP11-466J14.4 | |
| cytochrome P450 2C18 | |
| CYPIIC18 | |
| cytochrome P450-6B/29C | |
| microsomal monooxygenase | |
| unspecific monooxygenase | |
| flavoprotein-linked monooxygenase | |
| (S)-mephenytoin hydroxylase associated cytochrome P450 | |
| cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 17 | |
| cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 18 | |
| cytochrome P450 2C37 | |
| CYPIIC37 | |
| cytochrome P450, 2c37 | |
| AI266900 | |
| cytochrome P450 2C50 | |
| CYPIIC50 | |
| cytochrome P450, 2c50 | |
| EG404195 | |
| cytochrome P450 2C54 | |
| CYPIIC54 | |
| Cyp2c37 | |
| cytochrome P450, family 2, subfamily c, polypeptide 6, variant 2 | |
| cytochrome P450, family 2, subfamily c, polypeptide 37 | |
| PB1 | |
| PTF2 | |
| Cyp2c6 | |
| CYPIIC6 | |
| cytochrome P450 2C6 | |
| cytochrome P450 PB1 | |
| cytochrome P450, subfamily IIC6 | |
| P4502c80 | |
| P450 2C17 | |
| P4502C18 | |
| P4502C17 | |
| P450 2c80 | |
| P4502c55 | |
| P450 2c55 | |
| cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 | |
| P450-PROS2 | |
| LOC226104 | |
| P450 (CYP) 2c55 | |
| P450 (CYP) 2c80 | |
| P450 2C18 | |
| LOC639023 | |
| P450 (CYP) 2C18 | |
| DKFZp686I24235 | |
| cytochrome P450 2C54-like | |
| Cyp2c6v2 | |
| Cyp2c6v1 | |
| P4502c6 | |
| P450 2c6 | |
| P450 (CYP) 2c6 | |
| cytochrome P4502c6 | |
| cytochrome P450 II c6 | |
| cytochrome P450 CYP2C18 | |
| cytochrome P450 IIc6 | |
| CYPIIC55 | |
| CYPIIC17 | |
| Cyp2c80 | |
| Cyp2c55 | |
| cytochrome P450 2C17 | |
| Cytochrom P450 15-beta | |
| AF047725 | |
| 2010318C06 | |
| MGC109053 | |
| P450 (CYP) 2C17 | |
| CYP2C18 | |
| cytochrome P4502c55 | |
| OTTMUSP00000027819 | |
| OTTHUMP00000020131 | |
| NM_010003 | |
| LOC293989 | |
| cytochrome P450-PROS2 | |
| CYPIIC24 | |
| cytochrome P4502c80 | |
| cytochrome P4502C18 | |
| cytochrome P4502C17 | |
| cytochrome P450 IIC mephenytoin 4-hydroxylase 18 | |
| cytochrome P450 IIC mephenytoin 4-hydroxylase 17 | |
| cytochrome P450 2c80 | |
| cytochrome P450 2c55 |
| Mouse chromosome position | 19 |
|---|
| OMIM ID | 601131 |
|---|
| Rat chromosome position | 1q52 |
|---|---|
| 1q53 |
| Hugo ID | 2620 |
|---|
| Human chromosome position | 10q24 |
|---|
| Swiss-Prot Accession | P33260 |
|---|---|
| Q7Z348 | |
| P56654 | |
| Q9DBD9 | |
| Q91X77 | |
| Q6XVG2 | |
| Q5EB99 | |
| P05178 | |
| E9QPJ0 | |
| Q6XVG3 | |
| Q80X43 | |
| E9QKN4 | |
| B2R8K2 | |
| Q16703 | |
| Q16751 | |
| Q4VAT5 | |
| Q6GRG1 |
| PIR ID | A61269 |
|---|
| Unigene ID | Hs.511872 |
|---|---|
| Mm.38963 | |
| Mm.474575 | |
| Mm.379575 | |
| Rn.91122 |
| KEGG ID | hsa:1562 |
|---|---|
| mmu:13096 | |
| mmu:107141 | |
| mmu:404195 | |
| rno:293989 |
| Swiss-Prot ID | CP254_MOUSE |
|---|---|
| CY250_MOUSE | |
| CP237_MOUSE | |
| CP2CI_HUMAN |
| EC Number | 1.14.14.1 |
|---|
| Ensembl ID | ENSG00000108242 |
|---|---|
| ENSP00000285979 | |
| ENST00000285979 | |
| ENSP00000341293 | |
| ENST00000339022 | |
| ENSMUSG00000042248 | |
| ENSMUSP00000045362 | |
| ENSMUST00000049178 | |
| ENSMUSG00000054827 | |
| ENSMUSP00000068039 | |
| ENSMUST00000068094 | |
| ENSMUSP00000079065 | |
| ENSMUST00000080171 | |
| ENSMUSG00000067225 | |
| ENSMUSP00000048284 | |
| ENSMUST00000048959 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1306806 |
|---|---|
| 2147497 | |
| 3642960 |
| RGD ID | 1322740 |
|---|
| MedScan ID | 1561 |
|---|