| URN | urn:agi-llid:1559 |
|---|---|
| Total Entities | 0 |
| Connectivity | 977 |
| Name | CYP2C9 |
| Description | cytochrome P450, family 2, subfamily C, polypeptide 9 |
| Notes | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. |
| GO Molecular Function | oxidoreductase activity |
|---|---|
| monooxygenase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | |
| testosterone 16-alpha-hydroxylase activity | |
| (R)-limonene 6-monooxygenase activity | |
| (S)-limonene 6-monooxygenase activity | |
| (S)-limonene 7-monooxygenase activity | |
| aromatase activity | |
| steroid hydroxylase activity | |
| caffeine oxidase activity | |
| drug binding | |
| heme binding | |
| metal ion binding | |
| iron ion binding |
| GO Cellular Component | membrane |
|---|---|
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| intracellular membrane-bounded organelle |
| GO Biological Process | small molecule metabolic process |
|---|---|
| oxidation-reduction process | |
| oxidative demethylation | |
| steroid metabolic process | |
| arachidonic acid metabolic process | |
| omega-hydroxylase P450 pathway | |
| epoxygenase P450 pathway | |
| monoterpenoid metabolic process | |
| urea metabolic process | |
| monocarboxylic acid metabolic process | |
| xenobiotic metabolic process | |
| exogenous drug catabolic process | |
| drug metabolic process | |
| cellular amide metabolic process | |
| drug catabolic process |
| Pathway | Arachidonic acid metabolism |
|---|---|
| nateglinide pharmacokinetics pathway | |
| statin pharmacokinetics pathway | |
| warfarin pharmacokinetics pathway |
| Group | Leukotriene synthesis |
|---|---|
| small molecule metabolic process | |
| oxidation-reduction process | |
| oxidative demethylation | |
| oxidoreductase activity | |
| monooxygenase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | |
| testosterone 16-alpha-hydroxylase activity | |
| (R)-limonene 6-monooxygenase activity | |
| (S)-limonene 6-monooxygenase activity | |
| (S)-limonene 7-monooxygenase activity | |
| aromatase activity | |
| steroid hydroxylase activity | |
| caffeine oxidase activity | |
| steroid metabolic process | |
| arachidonic acid metabolic process | |
| omega-hydroxylase P450 pathway | |
| epoxygenase P450 pathway | |
| monoterpenoid metabolic process | |
| urea metabolic process | |
| monocarboxylic acid metabolic process | |
| xenobiotic metabolic process | |
| exogenous drug catabolic process | |
| drug metabolic process | |
| cellular amide metabolic process | |
| drug catabolic process | |
| drug binding | |
| heme binding | |
| metal ion binding | |
| iron ion binding | |
| membrane | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| intracellular membrane-bounded organelle |
| LocusLink ID | 1559 |
|---|---|
| 72082 | |
| 29277 | |
| 13095 | |
| 29298 |
| Cell Localization | Plasma membrane |
|---|---|
| Endoplasmic reticulum membrane | |
| Microsome membrane |
| GO ID | 0052741 |
|---|---|
| 0018675 | |
| 0018676 | |
| 0034875 | |
| 0008144 | |
| 0020037 | |
| 0005506 | |
| 0004497 | |
| 0016491 | |
| 0008395 | |
| 0019369 | |
| 0043603 | |
| 0042737 | |
| 0017144 | |
| 0019373 | |
| 0042738 | |
| 0032787 | |
| 0016098 | |
| 0097267 | |
| 0055114 | |
| 0070989 | |
| 0044281 | |
| 0008202 | |
| 0019627 | |
| 0006805 | |
| 0005783 | |
| 0005789 | |
| 0043231 | |
| 0070330 | |
| 0046872 | |
| 0016705 | |
| 0008390 | |
| 0016020 | |
| 0033767 | |
| 0009055 | |
| 0016712 | |
| 0005792 | |
| 0050381 | |
| 0005615 |
| Alias | CPC9 |
|---|---|
| CYP2C | |
| CYP2C10 | |
| CYPIIC9 | |
| P450IIC9 | |
| RP11-208C17.6 | |
| cytochrome P450 2C9 | |
| cytochrome P-450MP | |
| cytochrome P450 PB-1 | |
| microsomal monooxygenase | |
| xenobiotic monooxygenase | |
| flavoprotein-linked monooxygenase | |
| cytochrome P-450 S-mephenytoin 4-hydroxylase | |
| 2010318C06Rik | |
| cytochrome P450 2C55 | |
| CYPIIC55 | |
| cytochrome P450, 2c55 | |
| CYP2CII | |
| cytochrome P450 2C11 | |
| UT-2 | |
| P450H | |
| CYPIIC11 | |
| P450-UT-A | |
| P-450(M-1) | |
| cytochrome P450H | |
| cytochrome P450-UT-2 | |
| cytochrome P450-UT-A | |
| cytochrome P-450(M-1) | |
| cytochrome P450, 2c29 | |
| cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase) | |
| Cyp2c-11 | |
| Cyp2c-55 | |
| P450 MP-4 | |
| P450 (CYP) 2C9 | |
| P450 (CYP) MP IV | |
| P450 (CYP) MP-4 | |
| P450 (CYP) 2C10 | |
| P450 2C10 | |
| MGC88320 | |
| P450 2C9 | |
| P450 MP IV | |
| P4502C10 | |
| P4502C9 | |
| cytochrome P450 CYP2C9 | |
| cytochrome P450, subfamily 2, polypeptide 11 | |
| MGC149605 | |
| P-450MP | |
| cytochrome P4502C10 | |
| CYP2C9 | |
| cytochrome P450 2C10 | |
| cytochrome P450 IIC IX | |
| cytochrome P450 IIC mephenytoin 4-hydroxylase 10 | |
| cytochrome P4502C9 | |
| cytochrome P450 IIC mephenytoin 4-hydroxylase 9 | |
| cytochrome P450 IIC9 | |
| P450 PB-1 | |
| cytochrome P450, family 2, subfamily C, polypeptide 9 | |
| mephenytoin 4-hydroxylase | |
| cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 9 | |
| cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 10 | |
| AHOH | |
| Ah-2 | |
| Ahh-1 | |
| AHOHase | |
| P450-2C | |
| AI159681 | |
| AI196010 | |
| cytochrome P450, family 2, subfamily c, polypeptide 29 | |
| Cyp2c39 | |
| MGC156667 | |
| cytochrome P450, family 2, subfamily c, polypeptide 7 | |
| cytochrome P450, 2c39 | |
| mgc114253 | |
| Cyp2c70 | |
| cytochrome P450, family 2, subfamily c, polypeptide 70 | |
| similar to RIKEN cDNA 2010318C06 | |
| cytochrome P450, subfamily IIC, polypeptide 9 | |
| cytochrome P450, subfamily IIC, polypeptide IX | |
| P450 PB I | |
| cyp2c7 |
| Mouse chromosome position | 19 |
|---|---|
| 19 27.0 cM |
| OMIM ID | 601130 |
|---|---|
| 122700 |
| Rat chromosome position | 1q53 |
|---|
| Hugo ID | 2623 |
|---|
| Human chromosome position | 10q24 |
|---|
| Swiss-Prot Accession | P11712 |
|---|---|
| S5RV20 | |
| Q9D816 | |
| P08683 | |
| P11713 | |
| Q16756 | |
| Q16872 | |
| Q5VX92 | |
| Q63141 | |
| Q64554 |
| PIR ID | B38462 |
|---|---|
| D28951 | |
| A26685 | |
| S62785 |
| Unigene ID | Hs.282624 |
|---|---|
| Mm.142581 | |
| Rn.10870 | |
| Mm.20764 | |
| Rn.1247 |
| KEGG ID | hsa:1559 |
|---|---|
| mmu:72082 | |
| rno:29277 | |
| mmu:13095 | |
| rno:29298 |
| Swiss-Prot ID | CP2C9_HUMAN |
|---|---|
| CP2CB_RAT | |
| CP255_MOUSE |
| EC Number | 1.14.13.80 |
|---|---|
| 1.14.13.48 | |
| 1.14.13.49 | |
| 1.14.14.1 | |
| 1.14.13.- |
| Ensembl ID | ENSG00000138109 |
|---|---|
| ENSP00000260682 | |
| ENST00000260682 | |
| ENSMUSG00000025002 | |
| ENSMUSP00000025966 | |
| ENSMUST00000025966 | |
| ENSRNOG00000012896 | |
| ENSRNOP00000017310 | |
| ENSRNOT00000017310 |
| Homologene ID | 128042 |
|---|---|
| 86657 | |
| 103772 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1919332 |
|---|---|
| 103238 |
| RGD ID | 1317784 |
|---|
| MedScan ID | 1559 |
|---|