| URN | urn:agi-llid:1558 |
|---|---|
| Total Entities | 0 |
| Connectivity | 606 |
| Name | CYP2C8 |
| Description | cytochrome P450, family 2, subfamily C, polypeptide 8 |
| Notes | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. |
| GO Molecular Function | oxidoreductase activity |
|---|---|
| monooxygenase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | |
| aromatase activity | |
| caffeine oxidase activity | |
| heme binding | |
| metal ion binding | |
| iron ion binding |
| GO Cellular Component | membrane |
|---|---|
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| intracellular membrane-bounded organelle |
| GO Biological Process | small molecule metabolic process |
|---|---|
| oxidation-reduction process | |
| oxidative demethylation | |
| arachidonic acid metabolic process | |
| omega-hydroxylase P450 pathway | |
| epoxygenase P450 pathway | |
| organic acid metabolic process | |
| response to drug | |
| response to nutrient | |
| response to retinoic acid | |
| response to lipopolysaccharide | |
| response to ethanol | |
| response to peptide hormone | |
| xenobiotic metabolic process | |
| response to organonitrogen compound | |
| response to organic cyclic compound | |
| exogenous drug catabolic process | |
| drug metabolic process |
| Pathway | Arachidonic acid metabolism |
|---|---|
| Vitamin A (retinol) metabolism and visual cycle | |
| repaglinide pharmacokinetics pathway | |
| statin pharmacokinetics pathway | |
| warfarin pharmacokinetics pathway |
| Group | Leukotriene synthesis |
|---|---|
| small molecule metabolic process | |
| oxidation-reduction process | |
| oxidative demethylation | |
| oxidoreductase activity | |
| monooxygenase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | |
| aromatase activity | |
| caffeine oxidase activity | |
| arachidonic acid metabolic process | |
| omega-hydroxylase P450 pathway | |
| epoxygenase P450 pathway | |
| organic acid metabolic process | |
| response to drug | |
| response to nutrient | |
| response to retinoic acid | |
| response to lipopolysaccharide | |
| response to ethanol | |
| response to peptide hormone | |
| xenobiotic metabolic process | |
| response to organonitrogen compound | |
| response to organic cyclic compound | |
| exogenous drug catabolic process | |
| drug metabolic process | |
| heme binding | |
| metal ion binding | |
| iron ion binding | |
| membrane | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| intracellular membrane-bounded organelle |
| LocusLink ID | 1558 |
|---|---|
| 13095 | |
| 13097 | |
| 13098 | |
| 29298 | |
| 69888 | |
| 72303 | |
| 293985 |
| Cell Localization | Plasma membrane |
|---|---|
| Endoplasmic reticulum membrane | |
| Microsome membrane |
| GO ID | 0070330 |
|---|---|
| 0034875 | |
| 0020037 | |
| 0005506 | |
| 0004497 | |
| 0019369 | |
| 0017144 | |
| 0019373 | |
| 0042738 | |
| 0097267 | |
| 0006082 | |
| 0055114 | |
| 0070989 | |
| 0044281 | |
| 0006805 | |
| 0005783 | |
| 0005789 | |
| 0046872 | |
| 0016491 | |
| 0016705 | |
| 0016712 | |
| 0043231 | |
| 0016020 | |
| 0042493 | |
| 0045471 | |
| 0032496 | |
| 0007584 | |
| 0014070 | |
| 0010243 | |
| 0043434 | |
| 0032526 | |
| 0009055 | |
| 0050381 | |
| 0005792 | |
| 0003674 | |
| 0008150 | |
| 0005575 |
| Alias | CPC8 |
|---|---|
| CYPIIC8 | |
| MP-12/MP-20 | |
| cytochrome P450 2C8 | |
| P450 form 1 | |
| cytochrome P450 IIC2 | |
| cytochrome P450 MP-12 | |
| cytochrome P450 MP-20 | |
| cytochrome P450 form 1 | |
| microsomal monooxygenase | |
| xenobiotic monooxygenase | |
| s-mephenytoin 4-hydroxylase | |
| flavoprotein-linked monooxygenase | |
| cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8 | |
| AHOH | |
| Ah-2 | |
| Ahh-1 | |
| Cyp2c | |
| AHOHase | |
| P450-2C | |
| AI159681 | |
| AI196010 | |
| cytochrome P450 2C29 | |
| CYPIIC29 | |
| aldehyde oxygenase | |
| cytochrome P450, 2c29 | |
| cytochrome P-450 MUT-2 | |
| cytochrome P450 2C38 | |
| CYPIIC38 | |
| cytochrome P450, 2c38 | |
| CYPIIC39 | |
| cytochrome P450 2C39 | |
| cytochrome P450, 2c39 | |
| Cyp2c39 | |
| cytochrome P450 2C7 | |
| PTF1 | |
| P450F | |
| CYPIIC7 | |
| cytochrome P450F | |
| Cyp2c-7 | |
| P4502c29 | |
| P450 2c38 | |
| P450 2c29 | |
| Cyp2c38 | |
| P450 (CYP) 2c38 | |
| P450 (CYP) 2c29 | |
| P4502c38 | |
| cytochrome P450, family 2, subfamily c, polypeptide 38 | |
| P450 (CYP) 2c7 | |
| Cyp2c7 | |
| P4502c7 | |
| cytochrome P450 CYP2C8 | |
| P4502C8 | |
| P4502c79 | |
| cytochrome P4502c7 | |
| P450 (CYP) 2c39 | |
| P4502c39 | |
| MGC183632 | |
| LOC100361347 | |
| P4502c66 | |
| cytochrome P4502c39 | |
| cytochrome P450 CYP2C38 | |
| cytochrome P4502c38 | |
| cytochrome P450 CYP2C39 | |
| cytochrome P450 CYP2C7 | |
| LOC639008 | |
| P450 2c39 | |
| P450 2c7 | |
| cytochrome P4502c29 | |
| Cyp2c29 | |
| cytochrome P450 CYP2C29 | |
| CYP2C8 | |
| cytochrome P450 IIC8 isoform II | |
| cytochrome P450 IIC8 isoform I | |
| cytochrome P450 IIC8 isoform 2 | |
| cytochrome P450 IIC8 isoform 1 | |
| cytochrome P450 IIC mephenytoin 4-hydroxylase 8 | |
| cytochrome P450 2c79 | |
| Cyp2c79 | |
| Cyp2c66 | |
| Cyp2c65 | |
| LOC361754 | |
| 2210009K14 | |
| P4502c65 | |
| 2010301M18 | |
| cytochrome P450 2c66 | |
| P450 2C8 | |
| cytochrome P450 2c65 | |
| P450 IIC2 | |
| P450 2c79 | |
| P450 2c66 | |
| P450 2c65 | |
| P450 (CYP) MP-12/MP-20 | |
| P450 (CYP) IIC2 | |
| P450 (CYP) 2C8 | |
| P450 (CYP) 2c79 | |
| cytochrome P4502c79 | |
| P450 MP-12/MP-20 | |
| P450 (CYP) 2c66 | |
| cytochrome P4502c66 | |
| cytochrome P4502C8 | |
| MGC144816 | |
| MGC144817 | |
| OTTHUMP00000020134 | |
| P450 (CYP) 2c65 | |
| cytochrome P4502c65 | |
| cytochrome P450, family 2, subfamily C, polypeptide 8 | |
| 2010301M18Rik | |
| cytochrome P450, family 2, subfamily c, polypeptide 66 | |
| cytochrome P450, 2c66 | |
| 2210009K14Rik | |
| cytochrome P450, family 2, subfamily c, polypeptide 65 | |
| cytochrome P450, 2c65 | |
| cytochrome P450, family 2, subfamily c, polypeptide 79 (predicted) | |
| cytochrome P450, subfamily IIC, polypeptide 8 isoform 1 | |
| cytochrome P450, subfamily IIC, polypeptide 8 isoform I | |
| cytochrome P450, subfamily IIC, polypeptide 8 isoform 2 | |
| cytochrome P450, subfamily IIC, polypeptide 8 isoform II | |
| cytochrome P450 (Fundulus heteroclitus) | |
| P450 form I | |
| P450 form Is | |
| P450 form 1s | |
| hp1-1 | |
| hp1-2 |
| Mouse chromosome position | 19 33.91 cM |
|---|---|
| 19 | |
| 19 C3 |
| OMIM ID | 601129 |
|---|
| Rat chromosome position | 1q53 |
|---|
| Hugo ID | 2622 |
|---|
| Human chromosome position | 10q23.33 |
|---|
| Swiss-Prot Accession | P10632 |
|---|---|
| B7Z1F5 | |
| Q3UEF2 | |
| Q64458 | |
| P56655 | |
| P56656 | |
| P05179 | |
| B9EIA6 | |
| G5E854 | |
| A8K9N8 | |
| B0AZN2 | |
| B7Z1F6 | |
| Q5VX93 | |
| Q8WWB1 | |
| Q9UCZ9 | |
| Q63706 | |
| B2RWV4 | |
| F8VPK7 | |
| E9QMD8 | |
| Q8WUN8 |
| PIR ID | A29782 |
|---|---|
| B28516 | |
| I49610 |
| Unigene ID | Hs.709188 |
|---|---|
| Mm.20764 | |
| Mm.42100 | |
| Mm.42101 | |
| Rn.1247 | |
| Mm.426077 | |
| Mm.271190 |
| KEGG ID | hsa:1558 |
|---|---|
| mmu:13095 | |
| mmu:13097 | |
| mmu:13098 | |
| rno:29298 | |
| mmu:69888 | |
| mmu:72303 | |
| rno:293985 |
| Swiss-Prot ID | CP239_MOUSE |
|---|---|
| CP2C8_HUMAN | |
| CP2C7_RAT | |
| CP238_MOUSE | |
| CP2CT_MOUSE |
| EC Number | 1.14.14.1 |
|---|
| Ensembl ID | ENSG00000138115 |
|---|---|
| ENSP00000360317 | |
| ENST00000371270 | |
| ENSP00000445062 | |
| ENST00000535898 | |
| ENSMUSG00000003053 | |
| ENSMUSP00000003137 | |
| ENSMUST00000003137 | |
| ENSMUSG00000032808 | |
| ENSMUSP00000044722 | |
| ENSMUST00000035488 | |
| ENSMUSG00000025003 | |
| ENSMUSP00000025968 | |
| ENSMUST00000025968 | |
| ENSRNOG00000021405 | |
| ENSRNOP00000045029 | |
| ENSRNOT00000040325 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 103238 |
|---|---|
| 1306819 | |
| 1306818 | |
| 1917138 | |
| 1919553 |
| RGD ID | 1606589 |
|---|
| MedScan ID | 1558 |
|---|