| URN | urn:agi-llid:54600 |
|---|---|
| Total Entities | 0 |
| Connectivity | 248 |
| Name | UGT1A9 |
| Description | UDP glucuronosyltransferase 1 family, polypeptide A9 |
| Notes | This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenols. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | enzyme inhibitor activity |
|---|---|
| glucuronosyltransferase activity | |
| enzyme binding | |
| protein homodimerization activity | |
| protein heterodimerization activity | |
| retinoic acid binding |
| GO Cellular Component | integral component of membrane |
|---|---|
| endoplasmic reticulum membrane | |
| intracellular membrane-bounded organelle |
| GO Biological Process | metabolic process |
|---|---|
| small molecule metabolic process | |
| flavonoid glucuronidation | |
| xenobiotic glucuronidation | |
| cellular lipid metabolic process | |
| negative regulation of fatty acid metabolic process | |
| retinoic acid metabolic process | |
| flavone metabolic process | |
| xenobiotic metabolic process | |
| negative regulation of catalytic activity | |
| drug metabolic process |
| Pathway | warfarin pharmacokinetics pathway |
|---|
| Group | Glucose metabolism |
|---|---|
| Heme oxidation | |
| Steroid metabolism | |
| metabolic process | |
| small molecule metabolic process | |
| flavonoid glucuronidation | |
| xenobiotic glucuronidation | |
| cellular lipid metabolic process | |
| negative regulation of fatty acid metabolic process | |
| retinoic acid metabolic process | |
| flavone metabolic process | |
| xenobiotic metabolic process | |
| negative regulation of catalytic activity | |
| enzyme inhibitor activity | |
| glucuronosyltransferase activity | |
| drug metabolic process | |
| enzyme binding | |
| protein homodimerization activity | |
| protein heterodimerization activity | |
| retinoic acid binding | |
| integral component of membrane | |
| endoplasmic reticulum membrane | |
| intracellular membrane-bounded organelle |
| LocusLink ID | 54600 |
|---|
| Cell Localization | Cytoplasm |
|---|---|
| Mitochondria | |
| Microsome | |
| Endoplasmic reticulum membrane |
| GO ID | 0019899 |
|---|---|
| 0004857 | |
| 0015020 | |
| 0046982 | |
| 0042803 | |
| 0001972 | |
| 0044255 | |
| 0017144 | |
| 0051552 | |
| 0052696 | |
| 0008152 | |
| 0043086 | |
| 0045922 | |
| 0042573 | |
| 0044281 | |
| 0052697 | |
| 0006805 | |
| 0005789 | |
| 0016021 | |
| 0043231 |
| Alias | LUGP4 |
|---|---|
| UDPGT | |
| UGT1I | |
| HLUGP4 | |
| UGT-1I | |
| UGT1-9 | |
| UGT1.9 | |
| UGT1AI | |
| UGT1-09 | |
| UDPGT 1-9 | |
| UDP-glucuronosyltransferase 1-9 | |
| UDP-glucuronosyltransferase 1-I | |
| UDP-glucuronosyltransferase 1A9 | |
| UDP glycosyltransferase 1 family, polypeptide A9 | |
| UGT1 | |
| uridine diphosphate glucuronyltransferase 1A9 | |
| uridine diphosphate glucuronosyltransferase 1A9 | |
| UDP glucuronyltransferase 1A9 | |
| glucuronyltransferase 1A9 | |
| UGT1A9 | |
| UGT1*9 | |
| UDP glucuronosyltransferase 1 family, polypeptide A9 | |
| glucuronosyltransferase 1A9 |
| OMIM ID | 606434 |
|---|
| Hugo ID | 12541 |
|---|
| Human chromosome position | 2q37 |
|---|
| Swiss-Prot Accession | O60656 |
|---|---|
| Q5DSZ5 | |
| P36509 | |
| Q9HAX0 |
| PIR ID | S17512 |
|---|
| Unigene ID | Hs.554822 |
|---|
| KEGG ID | hsa:54600 |
|---|
| Swiss-Prot ID | UD19_HUMAN |
|---|
| EC Number | 2.4.1.17 |
|---|
| Ensembl ID | ENSG00000241119 |
|---|---|
| ENSG00000241635 | |
| ENSP00000476286 | |
| ENST00000609637 |
| Organism | Homo sapiens |
|---|
| RGD ID | 1348090 |
|---|
| MedScan ID | 54600 |
|---|