| URN | urn:agi-llid:54576 |
|---|---|
| Total Entities | 0 |
| Connectivity | 106 |
| Name | UGT1A8 |
| Description | UDP glucuronosyltransferase 1 family, polypeptide A8 |
| Notes | This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity with many substrates including coumarins, phenols, anthraquinones, flavones, and some opioids. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | enzyme inhibitor activity |
|---|---|
| glucuronosyltransferase activity | |
| drug binding | |
| enzyme binding | |
| protein homodimerization activity | |
| protein heterodimerization activity | |
| fatty acid binding | |
| retinoic acid binding | |
| steroid binding |
| GO Cellular Component | integral component of membrane |
|---|---|
| endoplasmic reticulum membrane | |
| intracellular membrane-bounded organelle |
| GO Biological Process | flavonoid glucuronidation |
|---|---|
| xenobiotic glucuronidation | |
| steroid metabolic process | |
| fatty acid metabolic process | |
| negative regulation of fatty acid metabolic process | |
| retinoic acid metabolic process | |
| negative regulation of steroid metabolic process | |
| coumarin metabolic process | |
| flavone metabolic process | |
| negative regulation of cellular metabolic process | |
| negative regulation of catalytic activity | |
| drug metabolic process |
| Pathway | warfarin pharmacokinetics pathway |
|---|
| Group | Glucose metabolism |
|---|---|
| Heme oxidation | |
| Steroid metabolism | |
| flavonoid glucuronidation | |
| xenobiotic glucuronidation | |
| steroid metabolic process | |
| fatty acid metabolic process | |
| negative regulation of fatty acid metabolic process | |
| retinoic acid metabolic process | |
| negative regulation of steroid metabolic process | |
| coumarin metabolic process | |
| flavone metabolic process | |
| negative regulation of cellular metabolic process | |
| negative regulation of catalytic activity | |
| enzyme inhibitor activity | |
| glucuronosyltransferase activity | |
| drug metabolic process | |
| drug binding | |
| enzyme binding | |
| protein homodimerization activity | |
| protein heterodimerization activity | |
| fatty acid binding | |
| retinoic acid binding | |
| steroid binding | |
| integral component of membrane | |
| endoplasmic reticulum membrane | |
| intracellular membrane-bounded organelle |
| LocusLink ID | 54576 |
|---|
| Cell Localization | Cytoplasm |
|---|---|
| Mitochondria | |
| Microsome | |
| Endoplasmic reticulum membrane |
| GO ID | 0008144 |
|---|---|
| 0019899 | |
| 0004857 | |
| 0005504 | |
| 0015020 | |
| 0046982 | |
| 0042803 | |
| 0001972 | |
| 0005496 | |
| 0009804 | |
| 0017144 | |
| 0006631 | |
| 0051552 | |
| 0052696 | |
| 0043086 | |
| 0031324 | |
| 0045922 | |
| 0045939 | |
| 0042573 | |
| 0008202 | |
| 0052697 | |
| 0005789 | |
| 0016021 | |
| 0043231 |
| Alias | UDPGT |
|---|---|
| UGT1H | |
| UGT-1H | |
| UGT1.8 | |
| UGT1-08 | |
| UGT1A8S | |
| UDPGT 1-8 | |
| UDP-glucuronosyltransferase 1-8 | |
| UDP-glucuronosyltransferase 1-H | |
| UDP-glucuronosyltransferase 1A8 | |
| UDP glycosyltransferase 1 family, polypeptide A8 | |
| UDP-glucuronosyltransferase 1 family polypeptide A8s | |
| UGT1 | |
| glucuronosyltransferase 1A8 | |
| glucuronyltransferase 1A8 | |
| UDP glucuronyltransferase 1A8 | |
| uridine diphosphate glucuronosyltransferase 1A8 | |
| uridine diphosphate glucuronyltransferase 1A8 | |
| UGT1A8 |
| OMIM ID | 606433 |
|---|
| Hugo ID | 12540 |
|---|
| Human chromosome position | 2q37 |
|---|
| Swiss-Prot Accession | Q5DSZ6 |
|---|---|
| Q9HAW9 | |
| B2R8S3 | |
| O14928 | |
| Q8TEX4 | |
| Q8WTQ9 | |
| Q8WX85 |
| Unigene ID | Hs.554822 |
|---|
| KEGG ID | hsa:54576 |
|---|
| Swiss-Prot ID | UD18_HUMAN |
|---|
| EC Number | 2.4.1.17 |
|---|
| Ensembl ID | ENSG00000241635 |
|---|---|
| ENSP00000362549 | |
| ENST00000373450 |
| Organism | Homo sapiens |
|---|
| RGD ID | 1342708 |
|---|
| MedScan ID | 54576 |
|---|