Protein UGT1A10

URN	urn:agi-llid:54575
Total Entities	0
Connectivity	129
Name	UGT1A10
Description	UDP glucuronosyltransferase 1 family, polypeptide A10
Notes	This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity on mycophenolic acid, coumarins, and quinolines. [provided by RefSeq, Jul 2008]

GO Molecular Function	enzyme inhibitor activity
	transferase activity
	transferase activity, transferring glycosyl groups
	transferase activity, transferring hexosyl groups
	glucuronosyltransferase activity
	drug binding
	enzyme binding
	protein kinase C binding
	protein homodimerization activity
	protein heterodimerization activity
	fatty acid binding
	retinoic acid binding
	steroid binding

GO Cellular Component	membrane
	integral component of membrane
	endoplasmic reticulum membrane
	endoplasmic reticulum
	intracellular membrane-bounded organelle

GO Biological Process	metabolic process
	coumarin catabolic process
	cellular glucuronidation
	flavonoid glucuronidation
	xenobiotic glucuronidation
	negative regulation of fatty acid metabolic process
	flavone metabolic process
	cellular response to organic cyclic compound
	negative regulation of catalytic activity
	drug metabolic process
	protein glucuronidation

Pathway	warfarin pharmacokinetics pathway

Group	Glucose metabolism
	Heme oxidation
	Steroid metabolism
	metabolic process
	coumarin catabolic process
	cellular glucuronidation
	flavonoid glucuronidation
	xenobiotic glucuronidation
	negative regulation of fatty acid metabolic process
	flavone metabolic process
	cellular response to organic cyclic compound
	negative regulation of catalytic activity
	enzyme inhibitor activity
	transferase activity
	transferase activity, transferring glycosyl groups
	transferase activity, transferring hexosyl groups
	glucuronosyltransferase activity
	drug metabolic process
	protein glucuronidation
	drug binding
	enzyme binding
	protein kinase C binding
	protein homodimerization activity
	protein heterodimerization activity
	fatty acid binding
	retinoic acid binding
	steroid binding
	membrane
	integral component of membrane
	endoplasmic reticulum membrane
	endoplasmic reticulum
	intracellular membrane-bounded organelle

Cell Localization	Cytoplasm
	Mitochondria
	Microsome
	Endoplasmic reticulum membrane

Alias	UDPGT
	UGT1J
	UGT-1J
	UGT1-10
	UGT1.10
	UDP-glucuronosyltransferase 1-10
	UDPGT 1-10
	UDP-glucuronosyltransferase 1-J
	UDP-glucuronosyltransferase 1A10
	UDP glycosyltransferase 1 family, polypeptide A10
	A13
	Ugt1a13
	UDP glycosyltransferase 1 family polypeptide A13
	UGTP4
	UGT1.9
	UGT1-09
	Ugt1a12
	mUGTBr/P
	UDPGT 1-9
	UDP-glucuronosyltransferase 1-9
	UDP-glucuronosyltransferase 1-7
	UDP-glucuronosyltransferase 1A9
	UDP glycosyltransferase 1 family polypeptide A12
	Ugt1
	Ugt1a9
	UDPGT 1-8
	UDP-glucuronosyltransferase 1-8
	A3
	UGT1*8
	UGT1.8
	UGT1-08
	UDP-glucuronosyltransferase 1A8
	UDP glucuronyltransferase 1A10
	UGT1*10
	UGT1A10
	Ugt1a11
	glucuronyltransferase 1A10
	uridine diphosphate glucuronosyltransferase 1A10
	uridine diphosphate glucuronyltransferase 1A10
	LOC100048744
	UDP-glucuronosyltransferase 1-9-like
	glucuronosyltransferase 1A10
	OTTMUSP00000022770
	MGC107546
	OTTHUMP00000065196
	OTTHUMP00000065197
	OTTMUSP00000022764
	OTTMUSP00000022765
	OTTMUSP00000022769
	OTTMUSP00000022771
	OTTMUSP00000022774
	OTTMUSP00000022776
	OTTMUSP00000022777
	UDP glycosyltransferase 1 family polypeptide A11
	OTTMUSP00000022772
	OTTMUSP00000022768

Mouse chromosome position	1

OMIM ID	606435

Rat chromosome position	9q35

Hugo ID	12531

Human chromosome position	2q37

PIR ID	JC5656

Swiss-Prot ID	UD19_MOUSE
	UD110_HUMAN

EC Number	2.4.1.17

MGI ID	3580642
	3576092

RGD ID	1346968

MedScan ID	54575