Protein UGT1A1

URN	urn:agi-llid:54658
Total Entities	0
Connectivity	718
Name	UGT1A1
Description	UDP glucuronosyltransferase 1 family, polypeptide A1
Notes	This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.

GO Molecular Function	enzyme inhibitor activity
	transferase activity
	transferase activity, transferring glycosyl groups
	transferase activity, transferring hexosyl groups
	glucuronosyltransferase activity
	enzyme binding
	protein homodimerization activity
	protein heterodimerization activity
	retinoic acid binding
	steroid binding

GO Cellular Component	membrane
	integral component of membrane
	integral component of plasma membrane
	endoplasmic reticulum membrane
	cytochrome complex
	endoplasmic reticulum
	intracellular membrane-bounded organelle

GO Biological Process	metabolic process
	small molecule metabolic process
	heme catabolic process
	cellular glucuronidation
	flavonoid glucuronidation
	xenobiotic glucuronidation
	steroid metabolic process
	retinoic acid metabolic process
	negative regulation of steroid metabolic process
	estrogen metabolic process
	flavone metabolic process
	digestion
	liver development
	organ regeneration
	response to drug
	response to organic substance
	response to nutrient
	response to lipopolysaccharide
	response to ethanol
	cellular response to ethanol
	xenobiotic metabolic process
	biphenyl catabolic process
	cellular response to hormone stimulus
	cellular response to glucocorticoid stimulus
	response to organic cyclic compound
	response to steroid hormone
	response to glucocorticoid
	response to starvation
	acute-phase response
	negative regulation of catalytic activity
	heterocycle metabolic process
	drug metabolic process
	bilirubin conjugation
	porphyrin-containing compound metabolic process

Pathway	New Pathway (2)
	paracetamol pharmacokinetics pathway
	statin pharmacokinetics pathway
	warfarin pharmacokinetics pathway

Group	Glucose metabolism
	Heme oxidation
	Steroid metabolism
	metabolic process
	small molecule metabolic process
	heme catabolic process
	cellular glucuronidation
	flavonoid glucuronidation
	xenobiotic glucuronidation
	steroid metabolic process
	retinoic acid metabolic process
	negative regulation of steroid metabolic process
	estrogen metabolic process
	flavone metabolic process
	digestion
	liver development
	organ regeneration
	response to drug
	response to organic substance
	response to nutrient
	response to lipopolysaccharide
	response to ethanol
	cellular response to ethanol
	xenobiotic metabolic process
	biphenyl catabolic process
	cellular response to hormone stimulus
	cellular response to glucocorticoid stimulus
	response to organic cyclic compound
	response to steroid hormone
	response to glucocorticoid
	response to starvation
	acute-phase response
	negative regulation of catalytic activity
	enzyme inhibitor activity
	transferase activity
	transferase activity, transferring glycosyl groups
	transferase activity, transferring hexosyl groups
	glucuronosyltransferase activity
	heterocycle metabolic process
	drug metabolic process
	bilirubin conjugation
	porphyrin-containing compound metabolic process
	enzyme binding
	protein homodimerization activity
	protein heterodimerization activity
	retinoic acid binding
	steroid binding
	membrane
	integral component of membrane
	integral component of plasma membrane
	endoplasmic reticulum membrane
	cytochrome complex
	endoplasmic reticulum
	intracellular membrane-bounded organelle

Cell Localization	Cytoplasm
	Mitochondria
	Microsome
	Endoplasmic reticulum membrane

Alias	GNT1
	UGT1
	UDPGT
	UGT1A
	HUG-BR1
	BILIQTL1
	UDPGT 1-1
	UDP-glucuronosyltransferase 1-1
	UGT-1A
	UGT1*1
	UGT1.1
	UGT1-01
	UDP-glucuronosyltransferase 1-A
	UDP-glucuronosyltransferase 1A1
	bilirubin-specific UDPGT isozyme 1
	bilirubin UDP-glucuronosyltransferase 1-1
	bilirubin UDP-glucuronosyltransferase isozyme 1
	UDP glycosyltransferase 1 family, polypeptide A1
	UgtBr1
	UGT1A01
	Udpgt-1a
	UDP-glucuronosyltransferase 1 family, member 1
	UDP-glucuronosyltransferase 1 family, polypeptide A1
	B1
	UDP-glucuronosyltransferase 1 family member 1
	Ugt1a I
	Ugt1a1
	glucuronosyltransferase 1A1
	uridine diphosphate glucuronosyltransferase 1A1
	glucuronyltransferase 1A1
	UDP-glucuronosyltransferase 1-1 precursor, microsomal
	Bilirubin specific isozyme 1
	Bilirubin specific isozyme I
	bilirubin UDP-glucuronosyltransferase isozyme I
	LOC130913
	LOC151508
	OTTMUSP00000022767
	UDP glucuronosyltransferase 1 family, polypeptide A1
	HUG-BR I
	OTTHUMP00000065199
	OTTMUSP00000022765
	OTTMUSP00000022769
	OTTMUSP00000022770
	OTTMUSP00000022771
	OTTMUSP00000022772
	OTTMUSP00000022774
	OTTMUSP00000022776
	OTTMUSP00000022777
	UDP glucuronosyltransferase 1A1
	Bilirubin specific isozyme I
	Bilirubin specific isozyme 1
	UGT1.1s
	Ugt1a2
	UDP-glucuronosyltransferase 1 family, member 2
	UDP-glucuronosyltransferase 1 family, member II

Mouse chromosome position	1 44.55 cM
	1 51.7 cM

Rat chromosome position	9q35-q36

Hugo ID	12530

Human chromosome position	2q37

PIR ID	I57961
	A39092

EC Number	2.4.1.17

Homologene ID	128034
	83117

MGI ID	98898

RGD ID	1350018

MedScan ID	54658

Primary Cell Localization	Cytoplasm
	Mitochondria