| URN | urn:agi-llid:54659 |
|---|---|
| Connectivity | 28 |
| Name | UGT1A3 |
| Description | UDP glucuronosyltransferase 1 family, polypeptide A3 |
| Notes | This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. Substrates of this enzyme include estrone, 2-hydroxyestrone, and metabolites of benzo alpha-pyrene. |
| Pathway | statin pharmacokinetics pathway |
|---|
| GO Molecular Function | UDP-glycosyltransferase activity |
|---|---|
| transferase activity, transferring hexosyl groups | |
| glucuronosyltransferase activity |
| GO Cellular Component | membrane |
|---|---|
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| microsome | |
| integral to membrane |
| GO Biological Process | metabolic process |
|---|---|
| liver development | |
| organ regeneration | |
| bilirubin conjugation | |
| biphenyl metabolic process | |
| response to drug | |
| response to nutrient | |
| response to starvation | |
| response to organic cyclic substance | |
| response to ethanol | |
| response to lipopolysaccharide | |
| response to glucocorticoid stimulus |
| Ariadne Ontology | Glucose metabolism |
|---|---|
| Steroid metabolism | |
| Heme oxidation |
| Group | Glucose metabolism |
|---|---|
| Steroid metabolism | |
| Heme oxidation | |
| metabolic process | |
| liver development | |
| organ regeneration | |
| bilirubin conjugation | |
| biphenyl metabolic process | |
| response to drug | |
| response to nutrient | |
| response to starvation | |
| response to organic cyclic substance | |
| response to ethanol | |
| response to lipopolysaccharide | |
| response to glucocorticoid stimulus | |
| UDP-glycosyltransferase activity | |
| transferase activity, transferring hexosyl groups | |
| glucuronosyltransferase activity | |
| membrane | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| microsome | |
| integral to membrane |
| MedScan ID | 54659 |
|---|
| Hugo ID | 12535 |
|---|
| Human chromosome position | 2q37 |
|---|
| LocusLink ID | 54659 |
|---|---|
| 22236 | |
| 396527 |
| Alias | UGT1C |
|---|---|
| UDPGT 1-3 | |
| UDP-glucuronosyltransferase 1-3 | |
| UDPGT | |
| UGT-1C | |
| UGT1*3 | |
| UGT1.3 | |
| UGT1-03 | |
| OTTHUMP00000065199 | |
| UDP glucuronosyltransferase 1A3 | |
| UDP-glucuronosyltransferase 1-C | |
| UDP-glucuronosyltransferase 1A3 | |
| UDP glycosyltransferase 1 family, polypeptide A3 | |
| Ugt1 | |
| UDPGT 1-2 | |
| UDP-glucuronosyltransferase 1-2 | |
| UGT1*0 | |
| UGT1.2 | |
| UGT1-02 | |
| OTTMUSP00000022760 | |
| OTTMUSP00000022765 | |
| OTTMUSP00000022769 | |
| OTTMUSP00000022770 | |
| OTTMUSP00000022771 | |
| OTTMUSP00000022772 | |
| OTTMUSP00000022774 | |
| OTTMUSP00000022776 | |
| OTTMUSP00000022777 | |
| bilirubin specific | |
| bilirubin-specific UDPGT | |
| UDP-glucuronosyltransferase 1 family, member 2 | |
| UDP-glucuronosyltransferase 1 family, polypeptide A2 | |
| B2 | |
| UDP glucuronosyltransferase 1A2 | |
| UDP glycosyltransferase 1 family polypeptide A2 | |
| OTTHUMP00000065193 | |
| UDP glucuronosyltransferase 1 family, polypeptide A2 | |
| UDP glucuronosyltransferase 1 family, polypeptide A3 | |
| UDP-glucuronosyltransferase 1 family, member II | |
| UDP-glucuronosyltransferase 1-3 precursor, microsomal | |
| Ugt1a2 | |
| UGT1A3 | |
| UDP-glucuronosyltransferase | |
| UDP glycosyltransferase 1 family, polypeptide A2 | |
| UGT1*3s | |
| udp glucuronosyltransferase 1 family, polypeptide a4 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 606428 |
|---|
| Mouse chromosome position | 1 |
|---|---|
| 1 D |
| GO ID | 0008194 |
|---|---|
| 0015020 | |
| 0008152 | |
| 0005783 | |
| 0005789 | |
| 0016021 | |
| 0016020 | |
| 0005792 | |
| 0001889 | |
| 0031100 | |
| 0014070 | |
| 0006789 | |
| 0018879 | |
| 0042493 | |
| 0045471 | |
| 0051384 | |
| 0032496 | |
| 0007584 | |
| 0042594 | |
| 0016758 | |
| 0016740 | |
| 0016757 |
| Rat chromosome position | 9q35-q36 |
|---|
| Swiss-Prot Accession | P35503 |
|---|---|
| Q5DT01 | |
| Q75XT3 | |
| Q75XT5 | |
| Q8WX89 | |
| Q8WX90 | |
| Q8WX91 | |
| P70691 | |
| Q545X2 | |
| Q6XL49 | |
| Q6T5F2 | |
| P20720 | |
| Q63886 |
| PIR ID | D42586 |
|---|
| Unigene ID | Hs.554822 |
|---|---|
| Mm.300095 | |
| Rn.26489 |
| KEGG ID | hsa:54659 |
|---|---|
| mmu:22236 | |
| rno:396527 |
| EC Number | 2.4.1.17 |
|---|
| Swiss-Prot ID | UD13_HUMAN |
|---|---|
| UD12_MOUSE | |
| Q6T5F2_RAT | |
| Q545X2_MOUSE | |
| Q5DT01_HUMAN |
| Cell Localization | Microsome |
|---|---|
| Endoplasmic reticulum membrane | |
| Cytoplasm | |
| Mitochondria |
| IPI ID | IPI00473079 |
|---|---|
| IPI00111936 | |
| IPI00421706 | |
| IPI00785460 | |
| IPI00134691 | |
| IPI00134432 | |
| IPI00417181 | |
| IPI00755661 | |
| IPI00677065 | |
| IPI00480429 | |
| IPI00417180 | |
| IPI00830493 | |
| IPI00831661 | |
| IPI00417182 | |
| IPI00416861 | |
| IPI00885677 | |
| IPI00202325 |
| Homologene ID | 88824 |
|---|
| RGD ID | 1352957 |
|---|
| MGI ID | 3576049 |
|---|