| URN | urn:agi-llid:1565 |
|---|---|
| Connectivity | 132 |
| Name | CYP2D6 |
| Description | cytochrome P450, family 2, subfamily D, polypeptide 6 |
| Notes | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Pathway | statin pharmacokinetics pathway |
|---|---|
| gefitinib pharmacokinetics pathway |
| GO Molecular Function | electron carrier activity |
|---|---|
| drug binding | |
| oxidoreductase activity | |
| heme binding | |
| metal ion binding | |
| monooxygenase activity | |
| steroid 21-monooxygenase activity | |
| arachidonic acid monooxygenase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | |
| aromatase activity |
| GO Cellular Component | membrane |
|---|---|
| cytoplasm | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| mitochondrion | |
| microsome |
| GO Biological Process | negative regulation of metabolic process |
|---|---|
| oxidation reduction | |
| xenobiotic metabolic process | |
| drug metabolic process | |
| heterocycle metabolic process | |
| isoquinoline alkaloid metabolic process | |
| coumarin metabolic process | |
| drug catabolic process | |
| arachidonic acid metabolic process | |
| alkaloid catabolic process | |
| dopamine metabolic process | |
| monoterpenoid metabolic process | |
| oxidative demethylation | |
| response to organic substance | |
| alkaloid metabolic process | |
| steroid metabolic process | |
| negative regulation of binding |
| Ariadne Ontology | Xenobiotic clearance |
|---|
| Group | Xenobiotic clearance |
|---|---|
| electron carrier activity | |
| negative regulation of metabolic process | |
| oxidation reduction | |
| xenobiotic metabolic process | |
| drug metabolic process | |
| heterocycle metabolic process | |
| isoquinoline alkaloid metabolic process | |
| coumarin metabolic process | |
| drug catabolic process | |
| arachidonic acid metabolic process | |
| alkaloid catabolic process | |
| dopamine metabolic process | |
| monoterpenoid metabolic process | |
| oxidative demethylation | |
| response to organic substance | |
| alkaloid metabolic process | |
| steroid metabolic process | |
| negative regulation of binding | |
| drug binding | |
| oxidoreductase activity | |
| heme binding | |
| metal ion binding | |
| monooxygenase activity | |
| steroid 21-monooxygenase activity | |
| arachidonic acid monooxygenase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | |
| aromatase activity | |
| membrane | |
| cytoplasm | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| mitochondrion | |
| microsome |
| MedScan ID | 1565 |
|---|
| Hugo ID | 2625 |
|---|
| Human chromosome position | 22q13.1 |
|---|
| LocusLink ID | 1565 |
|---|---|
| 56448 | |
| 171522 |
| Alias | CPD6 |
|---|---|
| CYP2D | |
| CYP2DL1 | |
| CYPIID6 | |
| P450C2D | |
| P450DB1 | |
| CYP2D7AP | |
| CYP2D7BP | |
| CYP2D7P2 | |
| CYP2D8P2 | |
| P450-DB1 | |
| MGC120389 | |
| MGC120390 | |
| RP4-669P10.2 | |
| cytochrome P450 2D6 | |
| cytochrome P450-DB1 | |
| microsomal monooxygenase | |
| xenobiotic monooxygenase | |
| debrisoquine 4-hydroxylase | |
| flavoprotein-linked monooxygenase | |
| cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2 | |
| cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2 | |
| cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing)-like 1 | |
| cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6 | |
| cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 2 | |
| cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising), polypeptide 8 pseudogene 2 | |
| 2D22 | |
| cytochrome P450, family 2, subfamily d, polypeptide 22 | |
| cytochrome P450, 2d22 | |
| Cyp2d6 | |
| Cyp2d18 | |
| Cyp2d22 | |
| Cyp2d4v1 | |
| Cyp2d4v2 | |
| cytochrome P450, family 2, subfamily d, polypeptide 4 | |
| CYPIID4 | |
| CYPIID18 | |
| P450-DB4 | |
| P450-CMF3 | |
| P450 2D-29/2D-35 | |
| cytochrome P450 2D4 | |
| cytochrome P450-DB4 | |
| cytochrome P450 2d18 | |
| cytochrome P450-CMF3 | |
| cytochrome P450 2D-29 | |
| cytochrome P450 2D-35 | |
| Cytochrome P450, subfamily IID4 | |
| cytochrome P450, subfamily 2D, polypeptide 6 | |
| cytochrome P450, subfamily IID, polypeptide 6 | |
| Cyp2d-18 | |
| Cyp2d4 | |
| CYP2DL I | |
| cytochrome P450 2d22 | |
| cytochrome P450 2d4v1 | |
| cytochrome P450 CYP2d22 | |
| cytochrome P450 IID debrisoquine, sparteine, etc., -metabolizing 6 | |
| cytochrome P450 IID debrisoquine, sparteine, etc., -metabolizing)-like 1 | |
| cytochrome P450 IID VI | |
| cytochrome P450 IId4 | |
| cytochrome P450 IID6 | |
| cytochrome P4502d18 | |
| cytochrome P4502d22 | |
| cytochrome P4502d4 | |
| cytochrome P4502d4v1 | |
| cytochrome P4502D6 | |
| P450 (CYP) 2d18 | |
| P450 (CYP) 2d22 | |
| P450 (CYP) 2d4 | |
| P450 (CYP) 2d4v1 | |
| P450 (CYP) 2D6 | |
| P450 2d18 | |
| P450 2d22 | |
| P450 2d4 | |
| P450 2d4v1 | |
| P450 2D6 | |
| P4502d18 | |
| P4502d22 | |
| P4502d4 | |
| P4502d4v1 | |
| P4502D6 | |
| CYP2D@ | |
| cytochrome P450, family 2, subfamily D, polypeptide 6 | |
| Debrisoquine 4-hydroxylase | |
| cytochrome P450, subfamily IID, polypeptide VI | |
| P450-DB I | |
| polypeptide 6 (mapped) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 124030 |
|---|---|
| 608902 |
| Mouse chromosome position | 15 |
|---|
| GO ID | 0070330 |
|---|---|
| 0008144 | |
| 0009055 | |
| 0020037 | |
| 0046872 | |
| 0004497 | |
| 0016491 | |
| 0009822 | |
| 0009820 | |
| 0009804 | |
| 0042737 | |
| 0017144 | |
| 0046483 | |
| 0033076 | |
| 0016098 | |
| 0051100 | |
| 0009892 | |
| 0055114 | |
| 0070989 | |
| 0008202 | |
| 0006805 | |
| 0005783 | |
| 0005789 | |
| 0016020 | |
| 0005792 | |
| 0005739 | |
| 0008391 | |
| 0004509 | |
| 0019369 | |
| 0042417 | |
| 0005737 | |
| 0010033 | |
| 0016712 | |
| 0005506 | |
| 0005575 | |
| 0019825 | |
| 0050381 | |
| 0016021 |
| Rat chromosome position | 7q34 |
|---|
| Swiss-Prot Accession | Q5Y7H2 |
|---|---|
| Q6NWU0 | |
| Q6NXU8 | |
| P10635 | |
| Q007T9 | |
| Q16753 | |
| Q16804 | |
| Q2XND0 | |
| Q2XND2 | |
| Q2XND3 | |
| Q2XND8 | |
| Q38LF9 | |
| Q38LG0 | |
| Q38LG2 | |
| Q3KPF3 | |
| Q59FG8 | |
| Q6ICD8 | |
| Q9JKY7 | |
| Q91W87 | |
| Q64680 | |
| P13108 | |
| Q566D3 |
| Unigene ID | Hs.648256 |
|---|---|
| Mm.174372 | |
| Rn.26060 |
| KEGG ID | hsa:1565 |
|---|---|
| mmu:56448 | |
| rno:171522 |
| EC Number | 1.14.14.1 |
|---|
| Swiss-Prot ID | CP2DI_RAT |
|---|---|
| Q9JKY7_MOUSE | |
| Q6NXU8_HUMAN | |
| Q6NWU0_HUMAN | |
| Q5Y7H2_HUMAN |
| Cell Localization | Endoplasmic reticulum membrane |
|---|---|
| Microsome membrane | |
| Plasma membrane |
| IPI ID | IPI00214539 |
|---|---|
| IPI00123619 | |
| IPI00433508 | |
| IPI00456699 | |
| IPI00477143 | |
| IPI00180313 | |
| IPI00873251 | |
| IPI00873166 | |
| IPI00868752 | |
| IPI00198325 |
| Homologene ID | 68036 |
|---|
| RGD ID | 736217 |
|---|
| MGI ID | 1929474 |
|---|