| URN | urn:agi-llid:10599 |
|---|---|
| Connectivity | 68 |
| Name | SLCO1B1 |
| Description | solute carrier organic anion transporter family, member 1B1 |
| Notes | This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq] |
| Pathway | nateglinide pharmacokinetics pathway |
|---|---|
| repaglinide pharmacokinetics pathway | |
| statin pharmacokinetics pathway | |
| axitinib pharmacokinetics pathway |
| GO Molecular Function | transporter activity |
|---|---|
| sodium-independent organic anion transmembrane transporter activity |
| GO Cellular Component | membrane |
|---|---|
| plasma membrane | |
| membrane fraction | |
| basolateral plasma membrane | |
| integral to plasma membrane |
| GO Biological Process | transport |
|---|---|
| ion transport | |
| organic anion transport |
| Ariadne Ontology | Organic anions transport |
|---|
| Group | Organic anions transport |
|---|---|
| transporter activity | |
| transport | |
| ion transport | |
| organic anion transport | |
| sodium-independent organic anion transmembrane transporter activity | |
| membrane | |
| plasma membrane | |
| membrane fraction | |
| basolateral plasma membrane | |
| integral to plasma membrane |
| MedScan ID | 10599 |
|---|
| Hugo ID | 10959 |
|---|
| Human chromosome position | 12p |
|---|
| LocusLink ID | 10599 |
|---|
| Alias | LST1 |
|---|---|
| LST-1 | |
| OATP2 | |
| OATPC | |
| OATP-C | |
| OATP1B1 | |
| SLC21A6 | |
| MGC133282 | |
| solute carrier organic anion transporter family member 1B1 | |
| OATP-2 | |
| solute carrier family 21 member 6 | |
| liver-specific organic anion transporter 1 | |
| sodium-independent organic anion-transporting polypeptide 2 | |
| solute carrier family 21 (organic anion transporter), member 6 | |
| hOATPC | |
| Organic anion transport polypeptide 2 | |
| Organic anion transport polypeptide II | |
| organic anion transporting polypeptide 2 | |
| organic anion transporting polypeptide-2 | |
| organic anion-transporting polypeptide 2 | |
| organic anion-transporting polypeptide C | |
| organic anion-transporting polypeptide-2 | |
| SLCO1B1 | |
| solute carrier family 21 (organic anion transporter), member VI | |
| solute carrier organic anion transporter family, member 1B1 | |
| Organic anion transport polypeptide II | |
| Organic anion transport polypeptide 2 |
| Organism | Homo sapiens |
|---|
| OMIM ID | 604843 |
|---|
| GO ID | 0015347 |
|---|---|
| 0005215 | |
| 0006811 | |
| 0015711 | |
| 0016323 | |
| 0005887 | |
| 0005624 | |
| 0005886 | |
| 0016020 | |
| 0006810 |
| Swiss-Prot Accession | Q05CV5 |
|---|---|
| Q9Y6L6 | |
| Q0VGM0 | |
| Q29R64 | |
| Q6NSF9 | |
| Q7Z4M3 | |
| B2R7G2 | |
| Q9NQ37 | |
| Q9UBF3 | |
| Q9UH89 |
| Unigene ID | Hs.449738 |
|---|
| KEGG ID | hsa:10599 |
|---|
| Swiss-Prot ID | SO1B1_HUMAN |
|---|---|
| Q05CV5_HUMAN | |
| B2R7G2_HUMAN |
| Cell Localization | Basolateral cell membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00295376 |
|---|---|
| IPI00022873 | |
| IPI00902630 | |
| IPI00243451 | |
| IPI00915396 |
| RGD ID | 1344263 |
|---|