| URN | urn:agi-llid:28234 |
|---|---|
| Connectivity | 60 |
| Name | SLCO1B3 |
| Description | solute carrier organic anion transporter family, member 1B3 |
| Notes | mediated uptake of a variety of organic anions including taurocholate, bromosulfophthalein and steroid conjugates [RGD] |
| Pathway | statin pharmacokinetics pathway |
|---|
| GO Molecular Function | transporter activity |
|---|---|
| drug transmembrane transporter activity | |
| oligopeptide transporter activity | |
| organic anion transmembrane transporter activity | |
| bile acid transmembrane transporter activity |
| GO Cellular Component | membrane |
|---|---|
| plasma membrane | |
| basolateral plasma membrane | |
| basal plasma membrane | |
| lateral plasma membrane | |
| integral to membrane | |
| integral to plasma membrane |
| GO Biological Process | transport |
|---|---|
| liver development | |
| response to drug | |
| response to antibiotic | |
| response to lipid | |
| response to cytokine stimulus | |
| response to lipopolysaccharide | |
| response to peptide hormone stimulus | |
| response to glucocorticoid stimulus | |
| drug transport | |
| ion transport | |
| oligopeptide transport | |
| organic anion transport | |
| bile acid and bile salt transport |
| Ariadne Ontology | Organic anions transport |
|---|
| Group | Organic anions transport |
|---|---|
| transporter activity | |
| transport | |
| liver development | |
| response to drug | |
| response to antibiotic | |
| response to lipid | |
| response to cytokine stimulus | |
| response to lipopolysaccharide | |
| response to peptide hormone stimulus | |
| response to glucocorticoid stimulus | |
| drug transport | |
| ion transport | |
| oligopeptide transport | |
| organic anion transport | |
| bile acid and bile salt transport | |
| drug transmembrane transporter activity | |
| oligopeptide transporter activity | |
| organic anion transmembrane transporter activity | |
| bile acid transmembrane transporter activity | |
| membrane | |
| plasma membrane | |
| basolateral plasma membrane | |
| basal plasma membrane | |
| lateral plasma membrane | |
| integral to membrane | |
| integral to plasma membrane |
| MedScan ID | 28234 |
|---|
| Hugo ID | 10961 |
|---|
| Human chromosome position | 12p12 |
|---|
| LocusLink ID | 28234 |
|---|---|
| 28253 | |
| 58978 |
| Alias | LST3 |
|---|---|
| OATP8 | |
| OATP1B3 | |
| SLC21A8 | |
| LST-3TM13 | |
| solute carrier organic anion transporter family member 1B3 | |
| LST-2 | |
| OATP-8 | |
| organic anion transporter 8 | |
| organic anion transporter LST-3c | |
| solute carrier family 21 member 8 | |
| organic anion-transporting polypeptide 8 | |
| liver-specific organic anion transporter 2 | |
| liver-specific organic anion transporter 3TM13 | |
| solute carrier family 21 (organic anion transporter), member 8 | |
| OATP2 | |
| Oatp4 | |
| lst-1 | |
| OATP-C | |
| mlst-1 | |
| Oatp1b2 | |
| Slc21a6 | |
| Slc21a10 | |
| 7330442B20Rik | |
| solute carrier organic anion transporter family member 1B2 | |
| OTTMUSP00000031099 | |
| solute carrier family 21 member 10 | |
| liver-specific organic anion transporter 1 | |
| solute carrier family (organic anion transporter) member 10 | |
| solute carrier family 21 (organic anion transporter), member 6 | |
| solute carrier family 21 (organic anion transporter), member 10 | |
| OATP-4 | |
| rlst-1 | |
| Slco1b2 | |
| liver-specific transporter-1 | |
| solute carrier family 21, member 10 | |
| organic anion transporting polypeptide 4 | |
| sodium-independent organic anion-transporting polypeptide 4 | |
| solute carrier organic anion transporter family, member 1b2 | |
| solute carrier family 21 (organic anion transporter) member 10 | |
| 7330442B20 | |
| Organic anion transporting polypeptide 8 | |
| Organic anion transporting polypeptide VIII | |
| Organic aniontransporter 8 | |
| Organic aniontransporter VIII | |
| SLCO1B3 | |
| solute carrier family 21 (organic anion transporter), member VIII | |
| solute carrier organic anion transporter family, member 1B3 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 605495 |
|---|
| Mouse chromosome position | 6 67.0 cM |
|---|
| GO ID | 0015125 |
|---|---|
| 0008514 | |
| 0005215 | |
| 0006811 | |
| 0015711 | |
| 0009925 | |
| 0005887 | |
| 0016328 | |
| 0005886 | |
| 0015238 | |
| 0015198 | |
| 0015721 | |
| 0015893 | |
| 0006857 | |
| 0006810 | |
| 0016323 | |
| 0016021 | |
| 0016020 | |
| 0001889 | |
| 0046677 | |
| 0034097 | |
| 0042493 | |
| 0051384 | |
| 0033993 | |
| 0032496 | |
| 0043434 | |
| 0008150 |
| Rat chromosome position | 4q44 |
|---|
| Swiss-Prot Accession | Q9NPD5 |
|---|---|
| Q0VGL9 | |
| Q5JAR4 | |
| Q6NSD0 | |
| Q7Z454 | |
| Q9JJL3 | |
| Q9QZX8 | |
| Q9JI79 | |
| Q9JJJ1 | |
| Q9JHF6 | |
| Q9JIM2 |
| PIR ID | JC7286 |
|---|
| Unigene ID | Hs.504966 |
|---|---|
| Mm.272223 | |
| Rn.48740 |
| KEGG ID | hsa:28234 |
|---|---|
| mmu:28253 | |
| rno:58978 |
| Swiss-Prot ID | SO1B2_MOUSE |
|---|---|
| SO1B2_RAT | |
| SO1B3_HUMAN |
| Cell Localization | Membrane |
|---|---|
| Basolateral cell membrane | |
| Basal cell membrane | |
| Lateral cell membrane | |
| Plasma membrane |
| IPI ID | IPI00121985 |
|---|---|
| IPI00230319 | |
| IPI00215390 | |
| IPI00231882 | |
| IPI00231883 | |
| IPI00022873 | |
| IPI00121895 |
| Homologene ID | 75119 |
|---|
| RGD ID | 1350750 |
|---|
| MGI ID | 1351899 |
|---|