Protein UGT1A1

URN	urn:agi-llid:54658
Connectivity	109
Name	UGT1A1
Description	UDP glucuronosyltransferase 1 family, polypeptide A1
Notes	This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.

Pathway	statin pharmacokinetics pathway

GO Molecular Function	glucuronosyltransferase activity

GO Cellular Component	membrane
	endoplasmic reticulum membrane
	endoplasmic reticulum
	microsome
	integral to membrane
	integral to plasma membrane

GO Biological Process	metabolic process
	digestion
	liver development
	organ regeneration
	estrogen metabolic process
	bilirubin conjugation
	biphenyl metabolic process
	biphenyl catabolic process
	cellular response to hormone stimulus
	cellular response to ethanol
	cellular response to glucocorticoid stimulus
	response to organic substance
	response to drug
	response to nutrient
	response to starvation
	response to organic cyclic substance
	response to ethanol
	response to lipopolysaccharide
	response to steroid hormone stimulus
	response to glucocorticoid stimulus

Group	Glucose metabolism
	Steroid metabolism
	Heme oxidation
	metabolic process
	digestion
	liver development
	organ regeneration
	estrogen metabolic process
	bilirubin conjugation
	biphenyl metabolic process
	biphenyl catabolic process
	cellular response to hormone stimulus
	cellular response to ethanol
	cellular response to glucocorticoid stimulus
	response to organic substance
	response to drug
	response to nutrient
	response to starvation
	response to organic cyclic substance
	response to ethanol
	response to lipopolysaccharide
	response to steroid hormone stimulus
	response to glucocorticoid stimulus
	glucuronosyltransferase activity
	membrane
	endoplasmic reticulum membrane
	endoplasmic reticulum
	microsome
	integral to membrane
	integral to plasma membrane

MedScan ID	54658

Hugo ID	12530

Human chromosome position	2q37

Alias	GNT1
	UGT1
	UDPGT
	UGT1A
	HUG-BR1
	BILIQTL1
	UDPGT 1-1
	UDP-glucuronosyltransferase 1-1
	UGT-1A
	UGT1*1
	UGT1.1
	UGT1-01
	OTTHUMP00000065199
	UDP-glucuronosyltransferase 1-A
	UDP-glucuronosyltransferase 1A1
	bilirubin-specific UDPGT isozyme 1
	bilirubin UDP-glucuronosyltransferase 1-1
	bilirubin UDP-glucuronosyltransferase isozyme 1
	UDP glycosyltransferase 1 family, polypeptide A1
	UgtBr1
	UGT1A01
	Udpgt-1a
	OTTMUSP00000022765
	OTTMUSP00000022767
	OTTMUSP00000022769
	OTTMUSP00000022770
	OTTMUSP00000022771
	OTTMUSP00000022772
	OTTMUSP00000022774
	OTTMUSP00000022776
	OTTMUSP00000022777
	UDP-glucuronosyltransferase 1 family, member 1
	UDP-glucuronosyltransferase 1 family, polypeptide A1
	B1
	UDP-glucuronosyltransferase 1 family member 1
	Bilirubin specific isozyme 1
	Bilirubin specific isozyme I
	bilirubin UDP-glucuronosyltransferase isozyme I
	HUG-BR I
	LOC130913
	LOC151508
	UDP glucuronosyltransferase 1 family, polypeptide A1
	UDP-glucuronosyltransferase 1-1 precursor, microsomal
	Ugt1a I
	Ugt1a1
	UDP glucuronosyltransferase 1A1
	Bilirubin specific isozyme I
	Bilirubin specific isozyme 1
	UGT1.1s
	Ugt1a2
	UDP-glucuronosyltransferase 1 family, member 2
	UDP-glucuronosyltransferase 1 family, member II

Mouse chromosome position	1 51.7 cM

Rat chromosome position	9q35-q36

PIR ID	I57961
	A39092

EC Number	2.4.1.17

Cell Localization	Microsome
	Endoplasmic reticulum membrane
	Cytoplasm
	Mitochondria

Homologene ID	83117

RGD ID	1350018

MGI ID	98898