Protein CYP2C9

URN	urn:agi-llid:1559
Connectivity	135
Name	CYP2C9
Description	cytochrome P450, family 2, subfamily C, polypeptide 9
Notes	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.

Pathway	nateglinide pharmacokinetics pathway
	statin pharmacokinetics pathway

GO Molecular Function	electron carrier activity
	oxygen binding
	drug binding
	oxidoreductase activity
	heme binding
	metal ion binding
	iron ion binding
	monooxygenase activity
	testosterone 16-alpha-hydroxylase activity
	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
	steroid hydroxylase activity
	aromatase activity
	4-hydroxyacetophenone monooxygenase activity
	(S)-limonene 6-monooxygenase activity
	(S)-limonene 7-monooxygenase activity
	caffeine oxidase activity

GO Cellular Component	membrane
	endoplasmic reticulum membrane
	endoplasmic reticulum
	microsome

GO Biological Process	oxidation reduction
	xenobiotic metabolic process
	drug metabolic process
	cellular amide metabolic process
	drug catabolic process
	monocarboxylic acid metabolic process
	urea metabolic process
	monoterpenoid metabolic process
	oxidative demethylation
	exogenous drug catabolic process
	steroid metabolic process

Ariadne Ontology	Leukotriene synthesis

Group	Leukotriene synthesis
	electron carrier activity
	oxidation reduction
	xenobiotic metabolic process
	drug metabolic process
	cellular amide metabolic process
	drug catabolic process
	monocarboxylic acid metabolic process
	urea metabolic process
	monoterpenoid metabolic process
	oxidative demethylation
	exogenous drug catabolic process
	steroid metabolic process
	oxygen binding
	drug binding
	oxidoreductase activity
	heme binding
	metal ion binding
	iron ion binding
	monooxygenase activity
	testosterone 16-alpha-hydroxylase activity
	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
	steroid hydroxylase activity
	aromatase activity
	4-hydroxyacetophenone monooxygenase activity
	(S)-limonene 6-monooxygenase activity
	(S)-limonene 7-monooxygenase activity
	caffeine oxidase activity
	membrane
	endoplasmic reticulum membrane
	endoplasmic reticulum
	microsome

MedScan ID	1559

Hugo ID	2623

Human chromosome position	10q24

Alias	CPC9
	CYP2C
	CYP2C10
	CYPIIC9
	MGC88320
	P450IIC9
	MGC149605
	RP11-208C17.6
	cytochrome P450 2C9
	cytochrome P-450MP
	cytochrome P450 PB-1
	microsomal monooxygenase
	xenobiotic monooxygenase
	flavoprotein-linked monooxygenase
	cytochrome P-450 S-mephenytoin 4-hydroxylase
	CYP2CII
	cytochrome P450 2C11
	UT-2
	P450H
	CYPIIC11
	P450-UT-A
	P-450(M-1)
	cytochrome P450H
	cytochrome P450-UT-2
	cytochrome P450-UT-A
	cytochrome P-450(M-1)
	cytochrome P450, 2c29
	cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase)
	Cyp2c-11
	CYP2C9
	cytochrome P450 2C10
	cytochrome P450 IIC IX
	cytochrome P450 IIC mephenytoin 4-hydroxylase 10
	cytochrome P450 IIC mephenytoin 4-hydroxylase 9
	cytochrome P450 IIC9
	cytochrome P450, subfamily 2, polypeptide 11
	cytochrome P4502C10
	cytochrome P4502C9
	P450 (CYP) 2C10
	P450 (CYP) 2C9
	P450 (CYP) MP IV
	P450 (CYP) MP-4
	P450 2C10
	P450 2C9
	P450 MP IV
	P450 MP-4
	P4502C10
	P4502C9
	P-450MP
	cytochrome P450, family 2, subfamily C, polypeptide 9
	OTTHUMP00000020135
	cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 9
	cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 10
	cytochrome P450, subfamily IIC, polypeptide 9
	cytochrome P450, subfamily IIC, polypeptide IX
	cytochrome P450, family 2, subfamily c, polypeptide 29
	Cyp2c29
	cyp2c7
	cytochrome p450, family 2, subfamily c, polypeptide 7
	P450 PB-1
	mephenytoin 4-hydroxylase
	AHOH
	Ah-2
	Ahh-1
	AHOHase
	P450-2C
	AI159681
	AI196010
	Cyp2c39
	MGC156667
	cytochrome P450, 2c39
	mgc114253
	Cyp2c70
	cytochrome P450, family 2, subfamily c, polypeptide 70
	similar to RIKEN cDNA 2010318C06
	P450 PB I

OMIM ID	601130
	122700

Mouse chromosome position	19 27.0 cM

Rat chromosome position	1q53

Cell Localization	Endoplasmic reticulum membrane
	Microsome membrane
	Plasma membrane

RGD ID	1317784

MGI ID	103238