| URN | urn:agi-llid:1558 |
|---|---|
| Connectivity | 69 |
| Name | CYP2C8 |
| Description | cytochrome P450, family 2, subfamily C, polypeptide 8 |
| Notes | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. |
| Pathway | repaglinide pharmacokinetics pathway |
|---|---|
| statin pharmacokinetics pathway |
| GO Molecular Function | electron carrier activity |
|---|---|
| oxygen binding | |
| oxidoreductase activity | |
| heme binding | |
| metal ion binding | |
| monooxygenase activity | |
| aromatase activity | |
| caffeine oxidase activity |
| GO Cellular Component | membrane |
|---|---|
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| microsome |
| GO Biological Process | oxidation reduction |
|---|---|
| drug metabolic process | |
| organic acid metabolic process | |
| oxidative demethylation | |
| exogenous drug catabolic process |
| Ariadne Ontology | Leukotriene synthesis |
|---|
| Group | Leukotriene synthesis |
|---|---|
| electron carrier activity | |
| oxidation reduction | |
| drug metabolic process | |
| organic acid metabolic process | |
| oxidative demethylation | |
| exogenous drug catabolic process | |
| oxygen binding | |
| oxidoreductase activity | |
| heme binding | |
| metal ion binding | |
| monooxygenase activity | |
| aromatase activity | |
| caffeine oxidase activity | |
| membrane | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| microsome |
| MedScan ID | 1558 |
|---|
| Hugo ID | 2622 |
|---|
| Human chromosome position | 10q23.33 |
|---|
| LocusLink ID | 1558 |
|---|---|
| 69888 | |
| 72303 | |
| 293985 |
| Alias | CPC8 |
|---|---|
| MP-12/MP-20 | |
| cytochrome P450 2C8 | |
| CYPIIC8 | |
| P450 form 1 | |
| cytochrome P450 IIC2 | |
| cytochrome P450 MP-12 | |
| cytochrome P450 MP-20 | |
| cytochrome P450 form 1 | |
| microsomal monooxygenase | |
| xenobiotic monooxygenase | |
| s-mephenytoin 4-hydroxylase | |
| flavoprotein-linked monooxygenase | |
| cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8 | |
| 2010301M18Rik | |
| cytochrome P450, family 2, subfamily c, polypeptide 66 | |
| cytochrome P450, 2c66 | |
| MGC144816 | |
| MGC144817 | |
| 2210009K14Rik | |
| cytochrome P450, family 2, subfamily c, polypeptide 65 | |
| cytochrome P450, 2c65 | |
| Cyp2c65 | |
| cytochrome P450, family 2, subfamily c, polypeptide 79 | |
| 2010301M18 | |
| 2210009K14 | |
| Cyp2c66 | |
| Cyp2c79 | |
| CYP2C8 | |
| cytochrome P450 2c65 | |
| cytochrome P450 2c66 | |
| cytochrome P450 2c79 | |
| cytochrome P450 IIC mephenytoin 4-hydroxylase 8 | |
| cytochrome P450 IIC8 isoform 1 | |
| cytochrome P450 IIC8 isoform 2 | |
| cytochrome P450 IIC8 isoform I | |
| cytochrome P450 IIC8 isoform II | |
| cytochrome P4502c65 | |
| cytochrome P4502c66 | |
| cytochrome P4502c79 | |
| cytochrome P4502C8 | |
| LOC434454 | |
| OTTHUMP00000020134 | |
| P450 (CYP) 2c65 | |
| P450 (CYP) 2c66 | |
| P450 (CYP) 2c79 | |
| P450 (CYP) 2C8 | |
| P450 (CYP) IIC2 | |
| P450 (CYP) MP-12/MP-20 | |
| P450 2c65 | |
| P450 2c66 | |
| P450 2c79 | |
| P450 2C8 | |
| P450 IIC2 | |
| P450 MP-12/MP-20 | |
| P4502c65 | |
| P4502c66 | |
| P4502c79 | |
| P4502C8 | |
| cytochrome P450, family 2, subfamily C, polypeptide 8 | |
| cytochrome P450, subfamily IIC, polypeptide 8 isoform 1 | |
| cytochrome P450, subfamily IIC, polypeptide 8 isoform I | |
| cytochrome P450, subfamily IIC, polypeptide 8 isoform 2 | |
| cytochrome P450, subfamily IIC, polypeptide 8 isoform II | |
| cytochrome P450, family 2, subfamily c, polypeptide 79 (predicted) | |
| cytochrome P450 (Fundulus heteroclitus) | |
| P450 form I | |
| P450 form Is | |
| P450 form 1s | |
| hp1-1 | |
| hp1-2 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 601129 |
|---|
| Mouse chromosome position | 19 |
|---|---|
| 19 C3 |
| GO ID | 0070330 |
|---|---|
| 0034875 | |
| 0009055 | |
| 0020037 | |
| 0046872 | |
| 0004497 | |
| 0019825 | |
| 0017144 | |
| 0042738 | |
| 0006082 | |
| 0055114 | |
| 0070989 | |
| 0005783 | |
| 0005789 | |
| 0016020 | |
| 0005792 | |
| 0016491 | |
| 0005506 | |
| 0003674 | |
| 0008150 | |
| 0005575 | |
| 0050381 |
| Rat chromosome position | 1q53 |
|---|
| Swiss-Prot Accession | P10632 |
|---|---|
| Q5GLZ0 | |
| Q148B1 | |
| Q5GLZ1 | |
| Q8QZU0 | |
| Q9CVC8 | |
| A8K9N8 | |
| B0AZN2 | |
| Q5VX93 | |
| Q8WWB1 | |
| Q9UCZ9 |
| PIR ID | A29782 |
|---|
| Unigene ID | Hs.709188 |
|---|---|
| Mm.271190 | |
| Mm.426077 |
| KEGG ID | hsa:1558 |
|---|---|
| mmu:69888 | |
| mmu:72303 | |
| rno:293985 |
| EC Number | 1.14.14.1 |
|---|
| Swiss-Prot ID | CP2C8_HUMAN |
|---|---|
| Q148B1_MOUSE | |
| Q9CVC8_MOUSE | |
| Q5GLZ0_MOUSE | |
| Q5GLZ1_MOUSE |
| Cell Localization | Endoplasmic reticulum membrane |
|---|---|
| Microsome membrane | |
| Plasma membrane |
| IPI ID | IPI00290301 |
|---|---|
| IPI00357250 | |
| IPI00462479 | |
| IPI00881514 | |
| IPI00777975 | |
| IPI00192118 | |
| IPI00766766 |
| RGD ID | 1606589 |
|---|
| MGI ID | 1917138 |
|---|---|
| 1919553 |