Protein ABCC2

URN	urn:agi-llid:1244
Connectivity	202
Name	ABCC2
Description	ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Notes	The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.

Pathway	statin pharmacokinetics pathway

GO Molecular Function	transporter activity
	nucleotide binding
	protein domain specific binding
	ATP binding
	ATPase activity, coupled to transmembrane movement of substances
	nucleoside-triphosphatase activity
	ATPase activity
	organic anion transmembrane transporter activity

GO Biological Process	transmembrane transport
	transport
	drug transmembrane transport
	cellular chloride ion homeostasis
	response to drug
	thyroid hormone transport
	prostaglandin transport

Ariadne Ontology	Organic anions transport

Group	Organic anions transport
	transporter activity
	transmembrane transport
	transport
	drug transmembrane transport
	cellular chloride ion homeostasis
	response to drug
	thyroid hormone transport
	prostaglandin transport
	nucleotide binding
	protein domain specific binding
	ATP binding
	ATPase activity, coupled to transmembrane movement of substances
	nucleoside-triphosphatase activity
	ATPase activity
	organic anion transmembrane transporter activity
	membrane
	membrane fraction
	apical plasma membrane
	integral to membrane
	integral to plasma membrane
	intercellular canaliculus

MedScan ID	1244

Hugo ID	53

Human chromosome position	10q24

LocusLink ID	1244
	12780

Alias	DJS
	MRP2
	cMRP
	ABC30
	CMOAT
	KIAA1010
	RP11-114F7.2
	canalicular multispecific organic anion transporter 1
	canalicular multidrug resistance protein
	multidrug resistance-associated protein 2
	ATP-binding cassette sub-family C member 2
	AI173996
	multidrug resistance protein 2
	Abcc2
	ATP-binding cassette transporter C (CFTR/MRP) 2
	ATP-binding cassette transporter C (CFTR/MRP) II
	ATP-binding cassette transporter C 2
	ATP-binding cassette transporter C II
	ATP-binding cassette, sub-family C (CFTR/MRP), member 2
	ATP-binding cassette, sub-family C (CFTR/MRP), member II
	ATP-binding cassette, sub-family C, member 2
	ATP-binding cassette, sub-family C, member II
	calicular multispecific organic anion transporter
	canalicular multispecific organic anion transporter
	Canalicular multispecific organic anion transporter I
	CMOAT I
	CMOAT1
	multidrug resistance protein II
	Multidrug resistance-associated protein II
	OTTHUMP00000020267
	rMRP2
	Multidrug resistance-associated protein 2
	Multidrug resistance-associated protein II
	CMOAT1s
	Canalicular multidrug resistance protein
	expressed sequence AI173996
	CMOAT Is

Organism	Homo sapiens
	Mus musculus

OMIM ID	601107
	237500

Mouse chromosome position	19 43.0 cM

PIR ID	S71841

Unigene ID	Hs.368243
	Mm.39054

KEGG ID	hsa:1244
	mmu:12780

Cell Localization	Membrane
	Plasma membrane

Homologene ID	68052

RGD ID	619569

MGI ID	1352447