| Name | CYP2C9 |
|---|---|
| Description | cytochrome P450, family 2, subfamily C, polypeptide 9 |
| Notes | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. |
| Owner | Public |
| URN | urn:agi-llid:1559 |
| Connectivity | 350 |
| LocusLink ID | 1559 |
|---|---|
| 13095 | |
| 29298 |
| OMIM ID | 601130 |
|---|---|
| 122700 |
| GO ID | 0018675 |
|---|---|
| 0018676 | |
| 0033767 | |
| 0009055 | |
| 0020037 | |
| 0005506 | |
| 0046872 | |
| 0016712 | |
| 0005783 | |
| 0005789 | |
| 0016020 | |
| 0005792 | |
| 0004497 | |
| 0016491 | |
| 0050381 | |
| 0005615 |
| Hugo ID | 2623 |
|---|
| Human chromosome position | 10q24 |
|---|
| Unigene ID | Hs.282624 |
|---|---|
| Mm.20764 | |
| Rn.1247 |
| KEGG ID | hsa:1559 |
|---|---|
| mmu:13095 | |
| rno:29298 |
| Alias | CPC9 |
|---|---|
| CYP2C | |
| CYP2C10 | |
| MGC88320 | |
| P450IIC9 | |
| MGC149605 | |
| P450 MP-4 | |
| P450 PB-1 | |
| cytochrome P450, family 2, subfamily C, polypeptide 9 | |
| cytochrome p4502C9 | |
| microsomal monooxygenase | |
| xenobiotic monooxygenase | |
| mephenytoin 4-hydroxylase | |
| flavoprotein-linked monooxygenase | |
| cytochrome P-450 S-mephenytoin 4-hydroxylase | |
| cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 9 | |
| cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 10 | |
| AHOH | |
| Ah-2 | |
| Ahh-1 | |
| AHOHase | |
| P450-2C | |
| AI159681 | |
| AI196010 | |
| cytochrome P450, family 2, subfamily c, polypeptide 29 | |
| cytochrome P450, 2c29 | |
| Cyp2c39 | |
| MGC156667 | |
| cytochrome P450, family 2, subfamily c, polypeptide 7 | |
| cytochrome P450, 2c39 | |
| mgc114253 | |
| CYP2C9 | |
| Cyp2c70 | |
| CYPIIC9 | |
| Cytochrome P450 2C9 | |
| cytochrome P450, family 2, subfamily c, polypeptide 70 | |
| similar to RIKEN cDNA 2010318C06 | |
| cytochrome P450, subfamily IIC, polypeptide 9 | |
| cytochrome P450, subfamily IIC, polypeptide IX | |
| P-450MP | |
| P450 MP IV | |
| P450 PB I | |
| cyp2c7 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| Mouse chromosome position | 19 27.0 cM |
|---|
| Rat chromosome position | 1q53 |
|---|
| Cell Localization | Plasma membrane |
|---|
| Homologene ID | 86657 |
|---|---|
| 103772 |
| Pathway | nateglinide pharmacokinetics pathway |
|---|
| MGI ID | 103238 |
|---|
| Ariadne Ontology | Leukotriene synthesis |
|---|
| RGD ID | 1317784 |
|---|
| GO Molecular Function | metal ion binding |
|---|---|
| iron ion binding | |
| heme binding | |
| oxidoreductase activity | |
| monooxygenase activity | |
| electron carrier activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | |
| 4-hydroxyacetophenone monooxygenase activity | |
| (S)-limonene 6-monooxygenase activity | |
| (S)-limonene 7-monooxygenase activity | |
| unspecific monooxygenase activity |
| GO Cellular Component | membrane |
|---|---|
| microsome | |
| endoplasmic reticulum | |
| endoplasmic reticulum membrane | |
| extracellular space |
| Group | membrane |
|---|---|
| microsome | |
| endoplasmic reticulum | |
| endoplasmic reticulum membrane | |
| extracellular space | |
| metal ion binding | |
| iron ion binding | |
| heme binding | |
| oxidoreductase activity | |
| monooxygenase activity | |
| electron carrier activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | |
| 4-hydroxyacetophenone monooxygenase activity | |
| (S)-limonene 6-monooxygenase activity | |
| (S)-limonene 7-monooxygenase activity | |
| unspecific monooxygenase activity | |
| Leukotriene synthesis |