| Name | CYP3A4 |
|---|---|
| Description | cytochrome P450, family 3, subfamily A, polypeptide 4 |
| Notes | This gene, CYP3A4, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs which are are used today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. |
| Owner | Public |
| URN | urn:agi-llid:1576 |
| Connectivity | 966 |
| LocusLink ID | 1576 |
|---|---|
| 13112 | |
| 53973 | |
| 337924 | |
| 25642 |
| OMIM ID | 124010 |
|---|
| GO ID | 0009055 |
|---|---|
| 0020037 | |
| 0005506 | |
| 0046872 | |
| 0004497 | |
| 0016712 | |
| 0019825 | |
| 0050591 | |
| 0033780 | |
| 0050649 | |
| 0006629 | |
| 0006805 | |
| 0009986 | |
| 0005783 | |
| 0005789 | |
| 0016021 | |
| 0016020 | |
| 0005624 | |
| 0005792 | |
| 0016491 | |
| 0050381 | |
| 0005615 | |
| 0003674 | |
| 0008150 | |
| 0005575 | |
| 0007568 | |
| 0046686 | |
| 0042493 | |
| 0051384 | |
| 0010038 | |
| 0007584 |
| Hugo ID | 2637 |
|---|
| Human chromosome position | 7q21.1 |
|---|
| Unigene ID | Hs.654391 |
|---|---|
| Mm.332844 | |
| Mm.379071 | |
| Mm.425301 | |
| Rn.91120 |
| KEGG ID | hsa:1576 |
|---|---|
| mmu:13112 | |
| mmu:53973 | |
| mmu:337924 | |
| rno:25642 |
| Alias | HLP |
|---|---|
| CP33 | |
| CP34 | |
| CYP3A | |
| NF-25 | |
| CYP3A3 | |
| P450C3 | |
| P450PCN1 | |
| MGC126680 | |
| cytochrome P450, subfamily IIIA, polypeptide 4 | |
| nifedipine oxidase | |
| P450-III, steroid inducible | |
| glucocorticoid-inducible P450 | |
| cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3 | |
| cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4 | |
| Pcn | |
| IIIAm1 | |
| AI256190 | |
| cytochrome P450, family 3, subfamily a, polypeptide 11 | |
| steroid inducible | |
| cytochrome P450, steroid inducible 3a11 | |
| Cyp3a41 | |
| cytochrome P450, family 3, subfamily a, polypeptide 41A | |
| cytochrome P450, steroid inducible 3a41 | |
| cytochrome P450, family 3, subfamily a, polypeptide 41 | |
| cytochrome P450, family 3, subfamily a, polypeptide 44 | |
| cytochrome P450, 3a44 | |
| CYP | |
| RL33 | |
| cDEX | |
| Cyp3a1 | |
| MGC108757 | |
| cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1 | |
| P450 IIIA | |
| cytochrome P450/6 beta B | |
| cytochrome P-450PCN (PNCN inducible) | |
| cytochrome P450, subfamily 3A, polypeptide 3 | |
| Cytochrome P450, subfamily IIIA, polypeptide 3 | |
| cytochrome P450, family 3, subfamily a, polypeptide 1 | |
| testosterone 6-beta-hydroxylase | |
| CYPIIIA3 | |
| Cytochrome P450 3A3 | |
| Cyp3a16 | |
| CYP3A9 | |
| Cytochrome P450 3A4 | |
| cytochrome P450, family 3, subfamily a, polypeptide 13 | |
| olfactory cytochrome P450olf3 | |
| 8430412F05 | |
| E330004N01 | |
| hypothetical protein 8430412F05 | |
| hypothetical protein FLJ11220 | |
| RIKEN cDNA C230004D03 gene | |
| cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide IV | |
| Cytochrome P450 3A21 (CYPIIIA21) (P450 CM3A-10) | |
| cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide III | |
| Cytochrome P450, subfamily IIIA, polypeptide III | |
| Cyp3a13 | |
| cytochrome P450, family 3, subfamily a, polypeptide 16 | |
| C230004D03Rik | |
| cytochrome P450 3A9 | |
| mKIAA3002 | |
| CYP3A4 | |
| cytochrome P450, subfamily IIIA, polypeptide IV | |
| P450PCN I | |
| FLJ11220 | |
| CYP3A2 | |
| CYPIIIA4 | |
| P450olf3 | |
| IIIAm2 | |
| IIIAm2s | |
| mgc93139 | |
| cyp3a23 | |
| RL 33 | |
| RL(33) | |
| RL-33 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| Mouse chromosome position | 5 85.0 cM |
|---|
| Rat chromosome position | 12p11 |
|---|
| Cell Localization | Plasma membrane |
|---|
| Pathway | repaglinide pharmacokinetics pathway |
|---|---|
| nateglinide pharmacokinetics pathway | |
| repaglinide pharmacokinetics pathway |
| MGI ID | 88609 |
|---|---|
| 1858451 | |
| 2449818 |
| Ariadne Ontology | Xenobiotic clearance |
|---|
| RGD ID | 1352962 |
|---|
| GO Molecular Function | molecular_function |
|---|---|
| oxygen binding | |
| metal ion binding | |
| iron ion binding | |
| heme binding | |
| oxidoreductase activity | |
| monooxygenase activity | |
| electron carrier activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | |
| taurochenodeoxycholate 6alpha-hydroxylase activity | |
| quinine 3-monooxygenase activity | |
| unspecific monooxygenase activity | |
| testosterone 6-beta-hydroxylase activity |
| GO Cellular Component | cellular_component |
|---|---|
| cell surface | |
| membrane | |
| membrane fraction | |
| microsome | |
| endoplasmic reticulum | |
| endoplasmic reticulum membrane | |
| integral to membrane | |
| extracellular space |
| GO Biological Process | biological_process |
|---|---|
| xenobiotic metabolic process | |
| aging | |
| lipid metabolic process | |
| response to drug | |
| response to nutrient | |
| response to glucocorticoid stimulus | |
| response to metal ion | |
| response to cadmium ion |
| Group | cellular_component |
|---|---|
| cell surface | |
| membrane | |
| membrane fraction | |
| microsome | |
| endoplasmic reticulum | |
| endoplasmic reticulum membrane | |
| integral to membrane | |
| extracellular space | |
| molecular_function | |
| oxygen binding | |
| metal ion binding | |
| iron ion binding | |
| heme binding | |
| oxidoreductase activity | |
| monooxygenase activity | |
| electron carrier activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | |
| taurochenodeoxycholate 6alpha-hydroxylase activity | |
| quinine 3-monooxygenase activity | |
| unspecific monooxygenase activity | |
| testosterone 6-beta-hydroxylase activity | |
| biological_process | |
| xenobiotic metabolic process | |
| aging | |
| lipid metabolic process | |
| response to drug | |
| response to nutrient | |
| response to glucocorticoid stimulus | |
| response to metal ion | |
| response to cadmium ion | |
| Xenobiotic clearance |