| Name | CYP2C8 |
|---|---|
| Description | cytochrome P450, family 2, subfamily C, polypeptide 8 |
| Notes | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. |
| Owner | Public |
| URN | urn:agi-llid:1558 |
| Connectivity | 225 |
| LocusLink ID | 1558 |
|---|---|
| 69888 | |
| 72303 | |
| 293985 |
| OMIM ID | 601129 |
|---|
| GO ID | 0009055 |
|---|---|
| 0020037 | |
| 0005506 | |
| 0046872 | |
| 0004497 | |
| 0050381 | |
| 0005783 | |
| 0005789 | |
| 0016020 | |
| 0005792 | |
| 0003674 | |
| 0016491 | |
| 0008150 | |
| 0005575 |
| Hugo ID | 2622 |
|---|
| Human chromosome position | 10q23.33 |
|---|
| Unigene ID | Hs.709188 |
|---|---|
| Mm.426077 | |
| Mm.271190 |
| KEGG ID | hsa:1558 |
|---|---|
| mmu:69888 | |
| mmu:72303 | |
| rno:293985 |
| Alias | CPC8 |
|---|---|
| MP-12/MP-20 | |
| cytochrome P450, family 2, subfamily C, polypeptide 8 | |
| P450 form 1 | |
| microsomal monooxygenase | |
| xenobiotic monooxygenase | |
| s-mephenytoin 4-hydroxylase | |
| flavoprotein-linked monooxygenase | |
| cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8 | |
| 2010301M18Rik | |
| cytochrome P450, family 2, subfamily c, polypeptide 66 | |
| cytochrome P450, 2c66 | |
| MGC144816 | |
| MGC144817 | |
| 2210009K14Rik | |
| cytochrome P450, family 2, subfamily c, polypeptide 65 | |
| cytochrome P450, 2c65 | |
| Cyp2c65 | |
| cytochrome P450, family 2, subfamily c, polypeptide 79 (predicted) | |
| P450 IIC2 | |
| P450 MP-12/MP-20 | |
| cytochrome P450, subfamily IIC, polypeptide 8 isoform 1 | |
| cytochrome P450, subfamily IIC, polypeptide 8 isoform I | |
| cytochrome P450, subfamily IIC, polypeptide 8 isoform 2 | |
| cytochrome P450, subfamily IIC, polypeptide 8 isoform II | |
| cytochrome P450 (Fundulus heteroclitus) | |
| P450 form I | |
| CYPIIC8 | |
| Cytochrome P450 2C8 | |
| CYP2C8 | |
| P450 form Is | |
| P450 form 1s | |
| hp1-1 | |
| hp1-2 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| Mouse chromosome position | 19 C3 |
|---|
| Rat chromosome position | 1q53 |
|---|
| Cell Localization | Plasma membrane |
|---|
| Pathway | repaglinide pharmacokinetics pathway |
|---|---|
| repaglinide pharmacokinetics pathway |
| MGI ID | 1917138 |
|---|---|
| 1919553 |
| Ariadne Ontology | Leukotriene synthesis |
|---|
| RGD ID | 1606589 |
|---|
| GO Molecular Function | molecular_function |
|---|---|
| metal ion binding | |
| iron ion binding | |
| heme binding | |
| oxidoreductase activity | |
| monooxygenase activity | |
| electron carrier activity | |
| unspecific monooxygenase activity |
| GO Cellular Component | cellular_component |
|---|---|
| membrane | |
| microsome | |
| endoplasmic reticulum | |
| endoplasmic reticulum membrane |
| GO Biological Process | biological_process |
|---|
| Group | cellular_component |
|---|---|
| membrane | |
| microsome | |
| endoplasmic reticulum | |
| endoplasmic reticulum membrane | |
| molecular_function | |
| metal ion binding | |
| iron ion binding | |
| heme binding | |
| oxidoreductase activity | |
| monooxygenase activity | |
| electron carrier activity | |
| unspecific monooxygenase activity | |
| biological_process | |
| Leukotriene synthesis |