| URN | urn:agi-llid:5300 |
|---|---|
| Total Entities | 0 |
| Connectivity | 564 |
| Name | Pin1 |
| Description | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 |
| Notes | Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011] |
| Ariadne Ontology | Protein folding |
|---|---|
| Secreted proteins |
| GO Molecular Function | GTPase activating protein binding |
|---|---|
| mitogen-activated protein kinase kinase binding | |
| phosphoserine binding | |
| phosphothreonine binding | |
| isomerase activity | |
| peptidyl-prolyl cis-trans isomerase activity |
| GO Cellular Component | nucleoplasm |
|---|---|
| nuclear speck | |
| midbody | |
| cytoplasm | |
| nucleus |
| GO Biological Process | cell cycle |
|---|---|
| regulation of mitosis | |
| negative regulation of ERK1 and ERK2 cascade | |
| negative regulation of transforming growth factor beta receptor signaling pathway | |
| regulation of pathway-restricted SMAD protein phosphorylation | |
| regulation of cytokinesis | |
| regulation of cell proliferation | |
| cytokine-mediated signaling pathway | |
| positive regulation of Rho GTPase activity | |
| positive regulation of protein phosphorylation | |
| positive regulation of ubiquitin-protein ligase activity | |
| negative regulation of cell motility | |
| protein folding | |
| protein peptidyl-prolyl isomerization | |
| innate immune response | |
| negative regulation of type I interferon production |
| Pathway | altered p53 signaling pathway |
|---|
| Group | Protein folding |
|---|---|
| cell cycle | |
| regulation of mitosis | |
| negative regulation of ERK1 and ERK2 cascade | |
| negative regulation of transforming growth factor beta receptor signaling pathway | |
| regulation of pathway-restricted SMAD protein phosphorylation | |
| regulation of cytokinesis | |
| regulation of cell proliferation | |
| cytokine-mediated signaling pathway | |
| positive regulation of Rho GTPase activity | |
| positive regulation of protein phosphorylation | |
| positive regulation of ubiquitin-protein ligase activity | |
| negative regulation of cell motility | |
| protein folding | |
| protein peptidyl-prolyl isomerization | |
| innate immune response | |
| negative regulation of type I interferon production | |
| GTPase activating protein binding | |
| mitogen-activated protein kinase kinase binding | |
| phosphoserine binding | |
| phosphothreonine binding | |
| isomerase activity | |
| peptidyl-prolyl cis-trans isomerase activity | |
| nucleoplasm | |
| nuclear speck | |
| midbody | |
| cytoplasm | |
| nucleus | |
| Secreted proteins |
| MedScan ID | 5300 |
|---|
| Hugo ID | 8988 |
|---|
| Human chromosome position | 19p13 |
|---|
| LocusLink ID | 5300 |
|---|---|
| 23988 | |
| 298696 |
| Alias | DOD |
|---|---|
| UBL5 | |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | |
| PPIase Pin1 | |
| rotamase Pin1 | |
| protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 | |
| D9Bwg1161e | |
| 0610025L01Rik | |
| peptidyl-prolyl cis-trans isomerase Pin1 | |
| prolyl isomerase | |
| Peptidyl-prolyl cis-trans isomerase NIMA-interactive 1 | |
| Peptidyl-prolyl cis-trans isomerase NIMA-interactive I | |
| Pin I | |
| peptidylprolyl cis/trans isomerase, NIMA-interacting 1 | |
| Pin1 | |
| Peptidyl-prolyl cis-trans isomerase NIMA-interacting I | |
| peptidyl-prolyl cis/trans isomerase, NIMA-interactive | |
| peptidyl-prolyl cis/trans isomerase, NIMA-interacting | |
| nima-interacting | |
| DNA segment, Chr 9, Brigham & Women's Genetics 1161 expressed | |
| 0610025L01 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 601052 |
|---|
| Unigene ID | Hs.465849 |
|---|---|
| Mm.7906 | |
| Rn.6291 |
| KEGG ID | hsa:5300 |
|---|---|
| mmu:23988 | |
| rno:298696 |
| Swiss-Prot Accession | Q13526 |
|---|---|
| Q9QUR7 | |
| B0BNL2 | |
| Q543B3 | |
| A8K4V9 | |
| Q53X75 |
| EC Number | 5.2.1.8 |
|---|
| GO ID | 0032794 |
|---|---|
| 0031434 | |
| 0003755 | |
| 0050815 | |
| 0050816 | |
| 0007049 | |
| 0019221 | |
| 0045087 | |
| 0070373 | |
| 2000146 | |
| 0030512 | |
| 0032480 | |
| 0032321 | |
| 0001934 | |
| 0051443 | |
| 0006457 | |
| 0000413 | |
| 0042127 | |
| 0032465 | |
| 0007088 | |
| 0060393 | |
| 0005737 | |
| 0030496 | |
| 0016607 | |
| 0005654 | |
| 0005634 | |
| 0016853 |
| PIR ID | JC7136 |
|---|---|
| S68520 |
| Swiss-Prot ID | PIN1_MOUSE |
|---|---|
| PIN1_HUMAN |
| Cell Localization | Nucleus |
|---|---|
| Nucleus speckle | |
| Cytoplasm |
| IPI ID | IPI00132093 |
|---|---|
| IPI00013723 |
| Mouse chromosome position | 9 4.0 cM |
|---|
| Rat chromosome position | 8q13 |
|---|
| Homologene ID | 4531 |
|---|
| MGI ID | 1346036 |
|---|
| RGD ID | 1310299 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|