Protein Mre11a

URN urn:agi-llid:4361
Total Entities 0
Connectivity 309
Name Mre11a
Description MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
Notes This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Ariadne Ontology DNA recombination
DNA repair
Telomere maintenance
GO Molecular Function protein C-terminus binding
DNA binding
double-stranded DNA binding
manganese ion binding
hydrolase activity
nuclease activity
exonuclease activity
endonuclease activity
endodeoxyribonuclease activity
single-stranded DNA specific endodeoxyribonuclease activity
3'-5' exonuclease activity
ATP-dependent DNA helicase activity
GO Cellular Component Mre11 complex
nucleoplasm
nucleolus
condensed nuclear chromosome
nuclear chromatin
chromosome, telomeric region
perinuclear region of cytoplasm
nucleus
GO Biological Process cell proliferation
reciprocal meiotic recombination
sister chromatid cohesion
cell cycle checkpoint
meiosis
negative regulation of DNA endoreduplication
synapsis
positive regulation of protein autophosphorylation
regulation of mitotic recombination
positive regulation of kinase activity
nucleic acid phosphodiester bond hydrolysis
DNA metabolic process
DNA repair
DNA recombination
telomere maintenance
double-strand break repair
double-strand break repair via homologous recombination
double-strand break repair via nonhomologous end joining
telomere maintenance via telomerase
DNA duplex unwinding
response to DNA damage stimulus
chromosome organization
heart development
Pathway Telomere Maintenance
Double Strand DNA Homologous Repair
Double Strand DNA Non-Homologous Repair
altered p53 signaling pathway
Group DNA recombination
DNA repair
Telomere maintenance
cell proliferation
reciprocal meiotic recombination
sister chromatid cohesion
cell cycle checkpoint
meiosis
negative regulation of DNA endoreduplication
synapsis
positive regulation of protein autophosphorylation
regulation of mitotic recombination
positive regulation of kinase activity
nucleic acid phosphodiester bond hydrolysis
DNA metabolic process
DNA repair
DNA recombination
telomere maintenance
double-strand break repair
double-strand break repair via homologous recombination
double-strand break repair via nonhomologous end joining
telomere maintenance via telomerase
DNA duplex unwinding
response to DNA damage stimulus
chromosome organization
heart development
protein C-terminus binding
DNA binding
double-stranded DNA binding
manganese ion binding
hydrolase activity
nuclease activity
exonuclease activity
endonuclease activity
endodeoxyribonuclease activity
single-stranded DNA specific endodeoxyribonuclease activity
3'-5' exonuclease activity
ATP-dependent DNA helicase activity
Mre11 complex
nucleoplasm
nucleolus
condensed nuclear chromosome
nuclear chromatin
chromosome, telomeric region
perinuclear region of cytoplasm
nucleus
MedScan ID 4361
Hugo ID 7230
Human chromosome position 11q21
GenBank ID NC_000011
NM_005591
NP_005582
NM_005590
NP_005581
NG_007261
NC_018922
AC_000143
AF303395
AAK18790
AP000765
AP000786
AY584241
AAS79320
CH471065
EAW66930
EAW66931
EAW66932
EAW66933
EAW66934
AF022778
AAD10197
AF073362
AAC36249
AK095388
BAG53039
AK308318
BC005241
AAH05241
BC017823
AAH17823
BC063458
AAH63458
BF574168
BT006730
AAP35376
U37359
AAC78721
P49959
JF432288
ADZ15505
NC_000075
NM_018736
NP_061206
AC_000031
AC136743
CH466522
EDL25006
EDL25007
EDL25008
CT030247
CAQ51549
CAQ51550
CAQ51551
CAQ51552
CAQ51553
AK041248
BAC30878
AK141214
BAE24593
AK146234
BAE27000
AK146370
BAE27119
AK161013
BAE36147
AK168180
BAE40140
AK168208
BC065144
AAH65144
U58987
AAB04955
U60318
AAB03664
Q61216
NC_005107
NM_022279
NP_071615
AC_000076
CH473993
EDL78461
EDL78462
EDL78463
AF218574
AAF91227
Q9JIM0
LocusLink ID 4361
17535
64046
Alias ATLD
HNGS1
MRE11
MRE11B
double-strand break repair protein MRE11A
AT-like disease
MRE11 homolog 1
MRE11 homolog A
endo/exonuclease Mre11
meiotic recombination 11 homolog 1
meiotic recombination 11 homolog A
DNA recombination and repair protein
RP23-149D5.3
mmMRE11A
MRE11 homolog I
MRE11 meiotic recombination 11 homolog A
MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
Mre11a
meiotic recombination 11 homolog A isoform II
AT-like disease gene
HNGS I
meiotic recombination 11 homolog A (S. cerevisiae)
meiotic recombination 11 homolog A isoform 1
meiotic recombination 11 homolog A isoform 2
Organism Homo sapiens
Mus musculus
Rattus norvegicus
OMIM ID 600814
604391
Unigene ID Hs.192649
Mm.149071
Rn.209040
KEGG ID hsa:4361
mmu:17535
rno:64046
Swiss-Prot Accession P49959
Q05D78
Q3URU4
Q61216
Q9JIM0
Q62430
O43475
GO ID 0008408
0004003
0003677
0003690
0004520
0030145
0004518
0008022
0000014
0032508
0006310
0006281
0000075
0008283
0006302
0000724
0006303
0007507
0032876
0090305
0033674
0031954
0007131
0000019
0006974
0007062
0007129
0007004
0030870
0000781
0000794
0000790
0005730
0005654
0005634
0048471
0004519
0004527
0016787
0006259
0051276
0007126
0000723
Swiss-Prot ID MRE11_MOUSE
MRE11_RAT
MRE11_HUMAN
Cell Localization Nucleus
IPI ID IPI00118853
IPI00283379
IPI00200709
IPI00218853
IPI00940798
Mouse chromosome position 9
Rat chromosome position 8q11
Homologene ID 4083
MGI ID 1100512
RGD ID 69263
Primary Cell Localization Nucleus