| URN | urn:agi-llid:7160 |
|---|---|
| Total Entities | 0 |
| Connectivity | 219 |
| Name | Tp63 |
| Description | tumor protein p63 |
| Notes | This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined. [provided by RefSeq, Jul 2008] |
| Ariadne Ontology | Transcription factors |
|---|---|
| Secreted proteins |
| GO Molecular Function | chromatin binding |
|---|---|
| p53 binding | |
| protein domain specific binding | |
| DNA binding | |
| damaged DNA binding | |
| sequence-specific DNA binding | |
| double-stranded DNA binding | |
| transcription regulatory region DNA binding | |
| metal ion binding | |
| sequence-specific DNA binding transcription factor activity | |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription |
| GO Cellular Component | nucleoplasm |
|---|---|
| nucleolus | |
| transcription factor complex | |
| chromatin | |
| protein complex | |
| cytoplasm | |
| cytosol | |
| Golgi apparatus | |
| rough endoplasmic reticulum | |
| nucleus | |
| neuron projection | |
| dendrite |
| GO Biological Process | cell cycle |
|---|---|
| cell aging | |
| mitotic cell cycle G1-S transition DNA damage checkpoint | |
| squamous basal epithelial stem cell differentiation involved in prostate gland acinus development | |
| ectoderm and mesoderm interaction | |
| positive regulation of Notch signaling pathway | |
| replicative cell aging | |
| intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | |
| DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | |
| Notch signaling pathway | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| negative regulation of transcription, DNA-dependent | |
| negative regulation of transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-dependent | |
| negative regulation of keratinocyte differentiation | |
| negative regulation of apoptotic process | |
| positive regulation of mesenchymal cell proliferation | |
| induction of apoptosis | |
| regulation of neuron apoptotic process | |
| cell differentiation | |
| epithelial cell development | |
| epithelial cell differentiation | |
| keratinocyte differentiation | |
| polarized epithelial cell differentiation | |
| transcription, DNA-dependent | |
| cellular response to UV | |
| apoptotic process | |
| neuron apoptotic process | |
| chromatin remodeling | |
| keratinocyte proliferation | |
| response to X-ray | |
| response to gamma radiation | |
| multicellular organismal development | |
| pattern specification process | |
| anatomical structure formation involved in morphogenesis | |
| prostate gland development | |
| female genitalia morphogenesis | |
| prostatic bud formation | |
| establishment of planar polarity | |
| hair follicle morphogenesis | |
| cloacal septation | |
| skin morphogenesis | |
| sympathetic nervous system development | |
| skeletal system development | |
| urinary bladder development | |
| epidermis development | |
| hair follicle development | |
| smooth muscle tissue development | |
| proximal-distal pattern formation | |
| post-anal tail morphogenesis | |
| organ morphogenesis | |
| embryonic limb morphogenesis | |
| morphogenesis of a polarized epithelium | |
| odontogenesis of dentin-containing tooth | |
| multicellular organismal aging | |
| spermatogenesis | |
| protein tetramerization | |
| protein homotetramerization |
| Pathway | altered p53 signaling pathway |
|---|
| Group | Transcription factors |
|---|---|
| cell cycle | |
| cell aging | |
| mitotic cell cycle G1-S transition DNA damage checkpoint | |
| squamous basal epithelial stem cell differentiation involved in prostate gland acinus development | |
| ectoderm and mesoderm interaction | |
| positive regulation of Notch signaling pathway | |
| replicative cell aging | |
| intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | |
| DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | |
| Notch signaling pathway | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| negative regulation of transcription, DNA-dependent | |
| negative regulation of transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-dependent | |
| negative regulation of keratinocyte differentiation | |
| negative regulation of apoptotic process | |
| positive regulation of mesenchymal cell proliferation | |
| induction of apoptosis | |
| regulation of neuron apoptotic process | |
| cell differentiation | |
| epithelial cell development | |
| epithelial cell differentiation | |
| keratinocyte differentiation | |
| polarized epithelial cell differentiation | |
| transcription, DNA-dependent | |
| cellular response to UV | |
| apoptotic process | |
| neuron apoptotic process | |
| chromatin remodeling | |
| keratinocyte proliferation | |
| response to X-ray | |
| response to gamma radiation | |
| multicellular organismal development | |
| pattern specification process | |
| anatomical structure formation involved in morphogenesis | |
| prostate gland development | |
| female genitalia morphogenesis | |
| prostatic bud formation | |
| establishment of planar polarity | |
| hair follicle morphogenesis | |
| cloacal septation | |
| skin morphogenesis | |
| sympathetic nervous system development | |
| skeletal system development | |
| urinary bladder development | |
| epidermis development | |
| hair follicle development | |
| smooth muscle tissue development | |
| proximal-distal pattern formation | |
| post-anal tail morphogenesis | |
| organ morphogenesis | |
| embryonic limb morphogenesis | |
| morphogenesis of a polarized epithelium | |
| odontogenesis of dentin-containing tooth | |
| multicellular organismal aging | |
| spermatogenesis | |
| protein tetramerization | |
| protein homotetramerization | |
| chromatin binding | |
| p53 binding | |
| protein domain specific binding | |
| DNA binding | |
| damaged DNA binding | |
| sequence-specific DNA binding | |
| double-stranded DNA binding | |
| transcription regulatory region DNA binding | |
| metal ion binding | |
| sequence-specific DNA binding transcription factor activity | |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription | |
| nucleoplasm | |
| nucleolus | |
| transcription factor complex | |
| chromatin | |
| protein complex | |
| cytoplasm | |
| cytosol | |
| Golgi apparatus | |
| rough endoplasmic reticulum | |
| nucleus | |
| neuron projection | |
| dendrite | |
| Secreted proteins |
| MedScan ID | 7160 |
|---|
| Hugo ID | 15979 |
|---|
| Human chromosome position | 3q28 |
|---|
| LocusLink ID | 7160 |
|---|---|
| 8626 | |
| 22061 | |
| 246334 |
| Alias | AIS |
|---|---|
| KET | |
| LMS | |
| NBP | |
| RHS | |
| p40 | |
| p51 | |
| p63 | |
| EEC3 | |
| OFC8 | |
| p73H | |
| p73L | |
| SHFM4 | |
| TP53L | |
| TP73L | |
| p53CP | |
| TP53CP | |
| B(p51A) | |
| B(p51B) | |
| tumor protein 63 | |
| CUSP | |
| transformation-related protein 63 | |
| tumor protein p53-competing protein | |
| amplified in squamous cell carcinoma | |
| chronic ulcerative stomatitis protein | |
| keratinocyte transcription factor KET | |
| tumor protein p63 deltaN isoform delta | |
| Tp63 | |
| P51/P63 | |
| AI462811 | |
| Trp53rp1 | |
| Trp63 | |
| tumor protein 63 kDa | |
| transformation related protein 63 | |
| p63 TA gamma | |
| p63 TA beta | |
| tumour protein p73-like | |
| TAp63 | |
| ta p63 beta | |
| Trp53rp I | |
| tumor p63 | |
| tumor protein 63 kDa with strong homology to p53 | |
| tumor protein p53-like | |
| tumor protein p73-like | |
| tumour p63 | |
| tumour protein 63 kDa | |
| tumour protein 63 kDa with strong homology to p53 | |
| tumour protein p53-competing protein | |
| tumour protein p53-like | |
| OTTHUMP00000209742 | |
| Limb-mammary syndrome gene | |
| OTTMUSP00000023060 | |
| p63 DN gamma | |
| dn p63 alpha | |
| dn p63 beta | |
| KET protein | |
| Limb-mammary syndrome protein | |
| MGC115972 | |
| p51A | |
| p63 DN beta | |
| p53 homolog | |
| p51B | |
| OTTMUSP00000023064 | |
| OTTMUSP00000023059 | |
| OTTHUMP00000209741 | |
| OTTHUMP00000209740 | |
| OTTHUMP00000209738 | |
| OTTHUMP00000209734 | |
| p53 competing protein |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 603273 |
|---|---|
| 103285 | |
| 604292 | |
| 106260 | |
| 603543 | |
| 129400 | |
| 605289 |
| Unigene ID | Hs.137569 |
|---|---|
| Mm.20894 | |
| Rn.42907 |
| KEGG ID | hsa:8626 |
|---|---|
| mmu:22061 | |
| rno:246334 |
| GO ID | 0003677 |
|---|---|
| 0001077 | |
| 0003682 | |
| 0003684 | |
| 0003690 | |
| 0046872 | |
| 0002039 | |
| 0043565 | |
| 0003700 | |
| 0044212 | |
| 0006978 | |
| 0007219 | |
| 0006915 | |
| 0007569 | |
| 0034644 | |
| 0006338 | |
| 0060197 | |
| 0007499 | |
| 0030326 | |
| 0002064 | |
| 0001736 | |
| 0048807 | |
| 0031069 | |
| 0006917 | |
| 0042771 | |
| 0030216 | |
| 0043616 | |
| 0031571 | |
| 0010259 | |
| 0043066 | |
| 0045617 | |
| 0000122 | |
| 0045892 | |
| 0051402 | |
| 0042475 | |
| 0030859 | |
| 0045747 | |
| 0002053 | |
| 0045944 | |
| 0045893 | |
| 0060513 | |
| 0051289 | |
| 0009954 | |
| 0043523 | |
| 0010165 | |
| 0010332 | |
| 0001501 | |
| 0043589 | |
| 0048745 | |
| 0060529 | |
| 0048485 | |
| 0060157 | |
| 0005794 | |
| 0000785 | |
| 0005737 | |
| 0005829 | |
| 0030425 | |
| 0005730 | |
| 0005654 | |
| 0005634 | |
| 0005667 | |
| 0019904 | |
| 0048646 | |
| 0007049 | |
| 0030154 | |
| 0008544 | |
| 0030855 | |
| 0001942 | |
| 0001738 | |
| 0007275 | |
| 0009887 | |
| 0007389 | |
| 0036342 | |
| 0030850 | |
| 0051262 | |
| 0006355 | |
| 0001302 | |
| 0006351 | |
| 0043005 | |
| 0043234 | |
| 0005791 | |
| 0007283 | |
| 0006916 |
| Swiss-Prot ID | P63_HUMAN |
|---|---|
| P63_MOUSE | |
| P63_RAT |
| Cell Localization | Nucleus |
|---|
| IPI ID | IPI00184272 |
|---|---|
| IPI00301360 | |
| IPI00479019 | |
| IPI00513733 | |
| IPI00514017 | |
| IPI00514155 | |
| IPI00514298 | |
| IPI00514384 | |
| IPI00514665 | |
| IPI00514807 | |
| IPI00514871 | |
| IPI00514961 | |
| IPI00126538 | |
| IPI00135459 | |
| IPI00135460 | |
| IPI00515553 | |
| IPI00515634 | |
| IPI00896016 | |
| IPI00195064 | |
| IPI00195066 | |
| IPI00201860 | |
| IPI00392220 | |
| IPI00392221 | |
| IPI00392222 | |
| IPI00515764 | |
| IPI00515777 | |
| IPI00515806 |
| Mouse chromosome position | 16 19.3 cM |
|---|
| Rat chromosome position | 11q23 |
|---|
| Homologene ID | 31189 |
|---|
| MGI ID | 1330810 |
|---|
| RGD ID | 620863 |
|---|
| Primary Cell Localization | Nucleus |
|---|