| URN | urn:agi-llid:7161 |
|---|---|
| Total Entities | 0 |
| Connectivity | 804 |
| Name | Tp73 |
| Description | tumor protein p73 |
| Notes | This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011] |
| Ariadne Ontology | Transcription factors |
|---|
| GO Molecular Function | chromatin binding |
|---|---|
| p53 binding | |
| transcription factor binding | |
| protein kinase binding | |
| DNA binding | |
| damaged DNA binding | |
| sequence-specific DNA binding | |
| double-stranded DNA binding | |
| transcription regulatory region DNA binding | |
| metal ion binding | |
| sequence-specific DNA binding transcription factor activity |
| GO Cellular Component | transcription factor complex |
|---|---|
| chromatin | |
| cytoplasm | |
| cytosol | |
| nucleus |
| GO Biological Process | cell cycle |
|---|---|
| cell cycle arrest | |
| mitotic cell cycle G1-S transition DNA damage checkpoint | |
| negative regulation of JUN kinase activity | |
| activation of MAPK activity | |
| intrinsic apoptotic signaling pathway in response to DNA damage response | |
| intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | |
| DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| negative regulation of transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-dependent | |
| negative regulation of neuron differentiation | |
| negative regulation of apoptotic process | |
| negative regulation of neuron apoptotic process | |
| positive regulation of oligodendrocyte differentiation | |
| positive regulation of apoptotic process | |
| regulation of apoptotic process | |
| regulation of neuron apoptotic process | |
| neuron development | |
| transcription, DNA-dependent | |
| mismatch repair | |
| response to DNA damage stimulus | |
| cellular response to UV | |
| apoptotic process | |
| release of cytochrome c from mitochondria | |
| response to organic nitrogen | |
| inflammatory response | |
| response to X-ray | |
| response to gamma radiation | |
| post-embryonic development | |
| forebrain development | |
| hippocampus development | |
| kidney development | |
| digestive tract morphogenesis | |
| cerebrospinal fluid secretion | |
| protein tetramerization | |
| positive regulation of cell size |
| Pathway | CD40LG/ATF2/AP-1/TP53/E2F Expression Targets |
|---|---|
| CD40LG/STAT Expression Targets | |
| altered p53 signaling pathway |
| Group | Transcription factors |
|---|---|
| cell cycle | |
| cell cycle arrest | |
| mitotic cell cycle G1-S transition DNA damage checkpoint | |
| negative regulation of JUN kinase activity | |
| activation of MAPK activity | |
| intrinsic apoptotic signaling pathway in response to DNA damage response | |
| intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | |
| DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| negative regulation of transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-dependent | |
| negative regulation of neuron differentiation | |
| negative regulation of apoptotic process | |
| negative regulation of neuron apoptotic process | |
| positive regulation of oligodendrocyte differentiation | |
| positive regulation of apoptotic process | |
| regulation of apoptotic process | |
| regulation of neuron apoptotic process | |
| neuron development | |
| transcription, DNA-dependent | |
| mismatch repair | |
| response to DNA damage stimulus | |
| cellular response to UV | |
| apoptotic process | |
| release of cytochrome c from mitochondria | |
| response to organic nitrogen | |
| inflammatory response | |
| response to X-ray | |
| response to gamma radiation | |
| post-embryonic development | |
| forebrain development | |
| hippocampus development | |
| kidney development | |
| digestive tract morphogenesis | |
| cerebrospinal fluid secretion | |
| protein tetramerization | |
| positive regulation of cell size | |
| chromatin binding | |
| p53 binding | |
| transcription factor binding | |
| protein kinase binding | |
| DNA binding | |
| damaged DNA binding | |
| sequence-specific DNA binding | |
| double-stranded DNA binding | |
| transcription regulatory region DNA binding | |
| metal ion binding | |
| sequence-specific DNA binding transcription factor activity | |
| transcription factor complex | |
| chromatin | |
| cytoplasm | |
| cytosol | |
| nucleus |
| MedScan ID | 7161 |
|---|
| Hugo ID | 12003 |
|---|
| Human chromosome position | 1p36.3 |
|---|
| LocusLink ID | 7161 |
|---|---|
| 22062 | |
| 362675 |
| Alias | P73 |
|---|---|
| tumor protein p73 | |
| p53-related protein | |
| p53-like transcription factor | |
| Tp73 | |
| RP23-254N4.10-001 | |
| Trp73 | |
| transformation related protein 73 | |
| p73alpha | |
| tumour protein p73 | |
| RP23-254N4.10 | |
| p73beta | |
| OTTHUMP00000003479 | |
| OTTHUMP00000000662 | |
| OTTHUMP00000003480 | |
| OTTMUSP00000011258 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 601990 |
|---|
| Unigene ID | Hs.192132 |
|---|---|
| Mm.78015 | |
| Rn.103860 |
| KEGG ID | hsa:7161 |
|---|---|
| mmu:22062 | |
| rno:362675 |
| Swiss-Prot Accession | O15350 |
|---|---|
| C9J521 | |
| B7Z7J4 | |
| Q9D6A3 | |
| Q9JJP2 | |
| D4AA88 | |
| B7Z9C1 | |
| O15351 | |
| Q17RN8 | |
| Q5TBV5 | |
| Q5TBV6 | |
| Q8NHW9 | |
| Q8TDY5 | |
| Q8TDY6 | |
| Q9NTK8 | |
| B1AX89 | |
| B1AX90 | |
| Q3UT91 | |
| Q9CU77 | |
| Q9JJP1 | |
| Q9WUJ0 |
| GO ID | 0003682 |
|---|---|
| 0003684 | |
| 0003690 | |
| 0046872 | |
| 0002039 | |
| 0019901 | |
| 0043565 | |
| 0003700 | |
| 0008134 | |
| 0044212 | |
| 0006978 | |
| 0000187 | |
| 0007050 | |
| 0034644 | |
| 0033326 | |
| 0048546 | |
| 0021766 | |
| 0006954 | |
| 0042771 | |
| 0008630 | |
| 0001822 | |
| 0006298 | |
| 0031571 | |
| 0043508 | |
| 0043524 | |
| 0045665 | |
| 0000122 | |
| 0048666 | |
| 0043065 | |
| 0045793 | |
| 0048714 | |
| 0045944 | |
| 0045893 | |
| 0009791 | |
| 0051262 | |
| 0001836 | |
| 0006974 | |
| 0010165 | |
| 0010332 | |
| 0010243 | |
| 0006351 | |
| 0000785 | |
| 0005829 | |
| 0005634 | |
| 0005667 | |
| 0003677 | |
| 0006915 | |
| 0007049 | |
| 0030900 | |
| 0043066 | |
| 0042981 | |
| 0043523 | |
| 0006355 | |
| 0005737 |
| Swiss-Prot ID | P73_HUMAN |
|---|---|
| P73_MOUSE |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm |
| IPI ID | IPI00006160 |
|---|---|
| IPI00215708 | |
| IPI00215709 | |
| IPI00215710 | |
| IPI00215711 | |
| IPI00215712 | |
| IPI00607588 | |
| IPI00607833 | |
| IPI00607886 | |
| IPI00648269 | |
| IPI00648744 | |
| IPI00652590 | |
| IPI00896107 |
| Mouse chromosome position | 4 82.0 cM |
|---|
| Rat chromosome position | 5q36 |
|---|
| Homologene ID | 3960 |
|---|
| MGI ID | 1336991 |
|---|
| RGD ID | 1307083 |
|---|
| Primary Cell Localization | Nucleus |
|---|