Protein Ets1

URN	urn:agi-llid:2113
Total Entities	0
Connectivity	626
Name	Ets1
Description	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
Notes	This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

Ariadne Ontology	Ets
	Oncogenes
	Secreted proteins
	Biofluids assayable substances

GO Molecular Function	transcription factor binding
	DNA binding
	sequence-specific DNA binding
	sequence-specific DNA binding transcription factor activity

GO Cellular Component	transcription factor complex
	nucleus

GO Biological Process	female pregnancy
	negative regulation of cell cycle
	regulation of extracellular matrix disassembly
	positive regulation of transcription, DNA-dependent
	positive regulation of transcription from RNA polymerase II promoter
	regulation of transcription, DNA-dependent
	regulation of transcription from RNA polymerase II promoter
	negative regulation of cell proliferation
	negative regulation of apoptotic process
	positive regulation of cell proliferation
	positive regulation of cellular component movement
	positive regulation of cell migration
	positive regulation of erythrocyte differentiation
	induction of apoptosis
	transcription, DNA-dependent
	transcription from RNA polymerase II promoter
	cell motility
	cellular response to hydrogen peroxide
	PML body organization
	immune response
	response to estradiol stimulus
	response to interleukin-1
	response to antibiotic
	response to hypoxia
	response to wounding
	response to laminar fluid shear stress
	response to mechanical stimulus
	positive regulation of angiogenesis
	angiogenesis involved in wound healing
	hypothalamus development
	pituitary gland development
	estrous cycle phase

Pathway	ERBB2/3 -> EP300/ETS/ETV/SP1 signaling
	BTC/EP300/ETS/ETV/SP1 Expression Targets
	NRG1/EP300/ETS/ETV/SP1 Expression Targets
	FGF2/AP-1/CREB/CREBBP/ELK-SRF/MYC Expression Targets
	FGF2/STAT Expression Targets
	EGF/AP-1/ATF Expression Targets
	EGF/STAT Expression Targets
	TGFB1-ACVRL1 Expression Targets
	TGFB1-TGFBR1/AP-1 Expression Targets
	IL1B Expression Targets
	EGF/CTNN Expression Targets
	altered p53 signaling pathway

Group	Ets
	Oncogenes
	female pregnancy
	negative regulation of cell cycle
	regulation of extracellular matrix disassembly
	positive regulation of transcription, DNA-dependent
	positive regulation of transcription from RNA polymerase II promoter
	regulation of transcription, DNA-dependent
	regulation of transcription from RNA polymerase II promoter
	negative regulation of cell proliferation
	negative regulation of apoptotic process
	positive regulation of cell proliferation
	positive regulation of cellular component movement
	positive regulation of cell migration
	positive regulation of erythrocyte differentiation
	induction of apoptosis
	transcription, DNA-dependent
	transcription from RNA polymerase II promoter
	cell motility
	cellular response to hydrogen peroxide
	PML body organization
	immune response
	response to estradiol stimulus
	response to interleukin-1
	response to antibiotic
	response to hypoxia
	response to wounding
	response to laminar fluid shear stress
	response to mechanical stimulus
	positive regulation of angiogenesis
	angiogenesis involved in wound healing
	hypothalamus development
	pituitary gland development
	estrous cycle phase
	transcription factor binding
	DNA binding
	sequence-specific DNA binding
	sequence-specific DNA binding transcription factor activity
	transcription factor complex
	nucleus
	Secreted proteins
	Biofluids assayable substances

MedScan ID	2113

Hugo ID	3488

Human chromosome position	11q23.3

Alias	ETS-1
	EWSR2
	protein C-ets-1
	p54
	ets protein
	v-ets avian erythroblastosis virus E2 oncogene homolog 1
	Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1
	Tpl1
	AI196000
	AI448617
	D230050P06
	C-ets-1 protein (p54)
	tumor progression locus 1
	avian erythroblastosis virus E26 oncogene 1
	Etsoncb
	Ets avian erythroblastosis virus E2 oncogene homolog 1 (tumor progression locus 1)
	MGC130355
	MGC18571
	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
	p42Ets-1
	MGC124638
	p51Ets-1
	Tp11
	Tpl I
	tumor progression locus I
	tumour progression locus 1
	tumour progression locus I
	v-ets avian erythroblastosis virus E2 oncogene homolog I
	v-ets avian erythroblastosis virus E26 oncogene homolog 1
	v-ets erythroblastosis virus E26 oncogene homolog 1
	v-ets erythroblastosis virus E26 oncogene homolog I
	LOC270138
	v-ets avian erythroblastosis virus E26 oncogene homolog I
	LOC235150
	E26 avian leukemia oncogene 1, 5' domain
	Avian erythroblastosis virus E26 (v-ets) oncogene homolog I
	C-ETS-1
	C-ETS-1 proteins
	E26 avian leukaemia oncogene 1, 5' domain
	Ets avian erythroblastosis virus E2 oncogene homolog 1 (tumour progression locus 1)
	ets avian erythroblastosis virus e2 oncogene homolog I
	FLJ10768
	Ets I
	ETS1
	ets avian erythroblastosis virus e2 oncogene homolog 1
	Etsoncbs

OMIM ID	164720

Cell Localization	Nucleus

Mouse chromosome position	9 15.0 cM

Rat chromosome position	8q21

Homologene ID	3837

MGI ID	95455

RGD ID	2583

Primary Cell Localization	Nucleus