Protein Srebf2

URN	urn:agi-llid:6721
Total Entities	0
Connectivity	462
Name	Srebf2
Description	sterol regulatory element binding factor 2 (predicted)
Notes	This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain.

Ariadne Ontology	Ubiquitous bHLH-ZIP factors
	Secreted proteins
	Biofluids assayable substances

GO Molecular Function	chromatin binding
	protein C-terminus binding
	DNA binding
	sequence-specific DNA binding
	RNA polymerase II core promoter proximal region sequence-specific DNA binding
	E-box binding
	C-8 sterol isomerase activity
	sequence-specific DNA binding transcription factor activity

GO Cellular Component	membrane
	Golgi membrane
	endoplasmic reticulum membrane
	ER to Golgi transport vesicle membrane
	SREBP-SCAP-Insig complex
	integral to membrane
	cytoplasm
	cytoplasmic vesicle
	endoplasmic reticulum
	Golgi apparatus
	intracellular membrane-bounded organelle
	nucleus
	dendrite

GO Biological Process	SREBP signaling pathway
	positive regulation of transcription, DNA-dependent
	positive regulation of transcription from RNA polymerase II promoter
	negative regulation of transcription from RNA polymerase II promoter
	regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
	regulation of transcription, DNA-dependent
	transcription, DNA-dependent
	cellular response to laminar fluid shear stress
	response to drug
	response to lead ion
	response to lipid
	response to hormone stimulus
	response to low-density lipoprotein particle stimulus
	negative regulation of cholesterol efflux
	positive regulation of cholesterol storage
	regulation of cholesterol homeostasis
	aging
	spermatogenesis
	lipid metabolic process
	lipid biosynthetic process
	steroid metabolic process
	cholesterol metabolic process

Pathway	InsulinR -> ELK-SRF/SREBF signaling
	FibronectinR -> AP-1/ELK-SRF/SREBF signaling
	Fibronectin Expression Targets
	Insulin/ELK-SRF/HIF1A/MYC/SREBF Expression Targets
	sterol regulatory element-binding protein signaling pathway
	altered p53 signaling pathway

Group	Ubiquitous bHLH-ZIP factors
	SREBP signaling pathway
	positive regulation of transcription, DNA-dependent
	positive regulation of transcription from RNA polymerase II promoter
	negative regulation of transcription from RNA polymerase II promoter
	regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
	regulation of transcription, DNA-dependent
	transcription, DNA-dependent
	cellular response to laminar fluid shear stress
	response to drug
	response to lead ion
	response to lipid
	response to hormone stimulus
	response to low-density lipoprotein particle stimulus
	negative regulation of cholesterol efflux
	positive regulation of cholesterol storage
	regulation of cholesterol homeostasis
	aging
	spermatogenesis
	lipid metabolic process
	lipid biosynthetic process
	steroid metabolic process
	cholesterol metabolic process
	chromatin binding
	protein C-terminus binding
	DNA binding
	sequence-specific DNA binding
	RNA polymerase II core promoter proximal region sequence-specific DNA binding
	E-box binding
	C-8 sterol isomerase activity
	sequence-specific DNA binding transcription factor activity
	membrane
	Golgi membrane
	endoplasmic reticulum membrane
	ER to Golgi transport vesicle membrane
	SREBP-SCAP-Insig complex
	integral to membrane
	cytoplasm
	cytoplasmic vesicle
	endoplasmic reticulum
	Golgi apparatus
	intracellular membrane-bounded organelle
	nucleus
	dendrite
	Secreted proteins
	Biofluids assayable substances

MedScan ID	6721

Hugo ID	11290

Human chromosome position	22q13

Alias	SREBP2
	bHLHd2
	CTA-250D10.14-005
	sterol regulatory element-binding protein 2
	SREBP-2
	class D basic helix-loop-helix protein 2
	sterol regulatory element-binding transcription factor 2
	nuc
	lop13
	AI608257
	SREBP2gc
	Srebf2_retired
	sterol regulatory element binding factor 2
	sterol regulatory element binding protein 2
	sterol response element-binding protein II
	sterol regulatory element binding factor II
	Sterol regulatory element binding protein II
	sterol regulatory element binding transcription factor 2
	sterol regulatory element binding transcription factor II
	sterol response element binding protein 2
	sterol response element binding protein-2
	sterol response element-binding protein 2
	sterol response element-binding protein-2
	OTTHUMP00000028740
	sterol response element binding protein-II
	CTA-250D10.14
	SRE binding protein-2
	SRE-binding factor II
	MGC124823
	SRE binding protein II
	SRE binding transcription factor 2
	SRE binding transcription factor II
	SRE2
	SRE2_HUMAN
	SREBF2
	SRE-binding factor 2
	Sterol regulatory element binding protein-2
	Srebf2s
	SREBP2s

OMIM ID	600481

PIR ID	A49397

Cell Localization	Endoplasmic reticulum membrane
	Golgi apparatus membrane
	Cytoplasmic vesicle
	COPII-coated vesicle membrane
	Nucleus

Mouse chromosome position	15
	15 E1

Rat chromosome position	7q34

Homologene ID	20966

MGI ID	107585
	96806

RGD ID	1307751

Primary Cell Localization	Nucleus