Elsevier Inc. Pin1 target genes NFY complex Vdr p53 regulators p53 methylation Mdm4 --+> genome instability Mdm2 --+> genome instability Mdm2 ---- Tp53 Mdm4 Mdm2 Srebf2 ---- Tp53 Tp53 --+> cell migration Pin1 ---- Tp53 Tp53 --+> cell invasion Tp53 Tp53 --+> genome instability Mre11a ---- Tp53 Tp53 ---| ataxia telangiectasia-mutated (ATM) signaling pathway ataxia telangiectasia-mutated (ATM) signaling pathway MRN complex endogenous stress ---> Tp53 exogenous stress ---> Tp53 Tp73 --+> tumor suppression Tp63 --+> tumor suppression tumor suppression Tp73 Tp63 Tp53 ---| Tp73 Tp53 ---| Tp63 Tp73 ---> target genes NFY complex ---- Tp53 Tp53 ---- Tp73 Tp53 ---- Tp63 Tp63 ---> target genes Ets1 Tp53 --+> chemoresistance Ets1 ---- Tp53 Tp53 ---- Vdr Tp53 --+> cell proliferation Mdm2 ---| Tp53 Mdm4 ---- Tp53 p53, Mdm2 acetylation ---> Tp53 p53 methylation ---> Tp53 NO p53, Mdm2 acetylation ---| Mdm2 p53, Mdm2 phosphorylation ---> Mdm2 p53, Mdm2 phosphorylation ---> Tp53 ataxia telangiectasia-mutated (ATM) signaling pathway ---> p53, Mdm2 phosphorylation endogenous stress Mdm4 ---| Tp53 p53 ubiquitination Mdm2 ---- Mdm4 p53, Mdm2 phosphorylation p53, Mdm2 acetylation Srebf2 Breast Neoplasms cell invasion cell migration genome instability genome instability ---> Neoplasms Tp53 --+> cell survival cell survival cell survival ---> Neoplasms cell proliferation chemoresistance chemoresistance ---> Neoplasms cell proliferation ---> Neoplasms Neoplasms Mre11a exogenous stress