| URN | urn:agi-llid:4193 |
|---|---|
| Connectivity | 686 |
| Name | Mdm2 |
| Description | transformed mouse 3T3 cell double minute 2 |
| Notes | mouse homolog acts to inhibit p53 growth suppression in Ras transformed cells [RGD] |
| Pathway | Sialophorin -> CTNNB/MYC/TP53 signaling |
|---|---|
| Apoptosis | |
| p53 signaling pathway |
| GO Molecular Function | ligase activity |
|---|---|
| p53 binding | |
| enzyme binding | |
| peroxisome proliferator activated receptor binding | |
| promoter binding | |
| metal ion binding | |
| zinc ion binding | |
| ubiquitin-protein ligase activity | |
| basal transcription repressor activity |
| GO Cellular Component | synapse |
|---|---|
| protein complex | |
| intracellular | |
| soluble fraction | |
| insoluble fraction | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| endocytic vesicle membrane | |
| nucleoplasm | |
| nucleolus | |
| nuclear body | |
| nucleus |
| GO Biological Process | positive regulation of cell proliferation |
|---|---|
| interspecies interaction between organisms | |
| establishment of protein localization | |
| positive regulation of cell cycle | |
| negative regulation of cell cycle arrest | |
| positive regulation of mitotic cell cycle | |
| traversing start control point of mitotic cell cycle | |
| negative regulation of DNA damage response, signal transduction by p53 class mediator | |
| cellular response to vitamin B1 | |
| positive regulation of proteasomal ubiquitin-dependent protein catabolic process | |
| negative regulation of transcription from RNA polymerase II promoter | |
| negative regulation of apoptosis | |
| positive regulation of protein export from nucleus | |
| negative regulation of caspase activity | |
| protein ubiquitination | |
| protein ubiquitination involved in ubiquitin-dependent protein catabolic process | |
| cellular response to organic substance | |
| cellular response to antibiotic | |
| cellular response to acid | |
| cellular response to growth factor stimulus | |
| cellular response to alkaloid | |
| cellular response to protein stimulus | |
| cellular response to organic cyclic substance | |
| cellular response to peptide hormone stimulus | |
| cellular response to estrogen stimulus | |
| cellular response to hydrogen peroxide | |
| cellular response to UV-C | |
| protein localization in nucleus | |
| response to drug | |
| response to toxin | |
| response to carbohydrate stimulus | |
| response to ether | |
| response to iron ion | |
| response to magnesium ion | |
| response to cocaine | |
| response to steroid hormone stimulus | |
| response to morphine | |
| negative regulation of gene expression | |
| negative regulation of protein maturation by peptide bond cleavage | |
| positive regulation of gene expression | |
| regulation of protein catabolic process | |
| protein destabilization | |
| protein complex assembly | |
| protein catabolic process |
| Ariadne Ontology | Ubiquitin-dependent protein degradation |
|---|---|
| MDM2-4 |
| Group | Ubiquitin-dependent protein degradation |
|---|---|
| MDM2-4 | |
| synapse | |
| positive regulation of cell proliferation | |
| interspecies interaction between organisms | |
| establishment of protein localization | |
| positive regulation of cell cycle | |
| negative regulation of cell cycle arrest | |
| positive regulation of mitotic cell cycle | |
| traversing start control point of mitotic cell cycle | |
| negative regulation of DNA damage response, signal transduction by p53 class mediator | |
| cellular response to vitamin B1 | |
| positive regulation of proteasomal ubiquitin-dependent protein catabolic process | |
| negative regulation of transcription from RNA polymerase II promoter | |
| negative regulation of apoptosis | |
| positive regulation of protein export from nucleus | |
| negative regulation of caspase activity | |
| protein ubiquitination | |
| protein ubiquitination involved in ubiquitin-dependent protein catabolic process | |
| cellular response to organic substance | |
| cellular response to antibiotic | |
| cellular response to acid | |
| cellular response to growth factor stimulus | |
| cellular response to alkaloid | |
| cellular response to protein stimulus | |
| cellular response to organic cyclic substance | |
| cellular response to peptide hormone stimulus | |
| cellular response to estrogen stimulus | |
| cellular response to hydrogen peroxide | |
| cellular response to UV-C | |
| protein localization in nucleus | |
| response to drug | |
| response to toxin | |
| response to carbohydrate stimulus | |
| response to ether | |
| response to iron ion | |
| response to magnesium ion | |
| response to cocaine | |
| response to steroid hormone stimulus | |
| response to morphine | |
| negative regulation of gene expression | |
| negative regulation of protein maturation by peptide bond cleavage | |
| positive regulation of gene expression | |
| regulation of protein catabolic process | |
| protein destabilization | |
| protein complex assembly | |
| protein catabolic process | |
| ligase activity | |
| p53 binding | |
| enzyme binding | |
| peroxisome proliferator activated receptor binding | |
| promoter binding | |
| metal ion binding | |
| zinc ion binding | |
| ubiquitin-protein ligase activity | |
| basal transcription repressor activity | |
| protein complex | |
| intracellular | |
| soluble fraction | |
| insoluble fraction | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| endocytic vesicle membrane | |
| nucleoplasm | |
| nucleolus | |
| nuclear body | |
| nucleus |
| MedScan ID | 4193 |
|---|
| Hugo ID | 6973 |
|---|
| Human chromosome position | 12q14.3-q15 |
|---|
| LocusLink ID | 4193 |
|---|---|
| 17246 | |
| 314856 | |
| 246362 |
| Alias | HDMX |
|---|---|
| hdm2 | |
| MGC5370 | |
| MGC71221 | |
| E3 ubiquitin-protein ligase Mdm2 | |
| oncoprotein Mdm2 | |
| MDM2 variant FB28 | |
| OTTHUMP00000183490 | |
| OTTHUMP00000183492 | |
| OTTHUMP00000183494 | |
| OTTHUMP00000183495 | |
| OTTHUMP00000183496 | |
| OTTHUMP00000183497 | |
| ubiquitin-protein ligase E3 Mdm2 | |
| double minute 2, human homolog of; p53-binding protein | |
| Mdm2, transformed 3T3 cell double minute 2, p53 binding protein | |
| Mdm-2 | |
| AA415488 | |
| 1700007J15Rik | |
| OTTMUSP00000022916 | |
| OTTMUSP00000022917 | |
| double minute 2 protein | |
| p53-binding protein Mdm2 | |
| double minute 2 | |
| transformed mouse 3T3 cell double minute 2 | |
| 1700007J15 | |
| double minute 2 homolog full length protein isoform | |
| double minute 2 homolog isoform MDM2a | |
| double minute 2 homolog isoform MDM2b | |
| double minute 2 homolog isoform MDM2c | |
| double minute 2 homolog isoform MDM2d | |
| double minute 2 homolog isoform MDM2e | |
| LOC113222 | |
| LOC116201 | |
| MDM2 | |
| Mdm2 p53 binding protein homolog (mouse) | |
| mdm2b | |
| mdm2c | |
| mdm2e | |
| mouse double minute 2 | |
| mouse double minute 2 homolog | |
| mouse double minute 2 homolog full length | |
| mouse double minute 2 homolog MDM2a | |
| mouse double minute 2 homolog MDM2b | |
| mouse double minute 2 homolog MDM2c | |
| mouse double minute 2 homolog MDM2d | |
| mouse double minute 2 homolog MDM2e | |
| mouse double minute II | |
| transformed mouse 3T3 cell double minute II |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 164785 |
|---|
| Mouse chromosome position | 10 66.0 cM |
|---|
| GO ID | 0017163 |
|---|---|
| 0019899 | |
| 0016874 | |
| 0046872 | |
| 0002039 | |
| 0004842 | |
| 0008270 | |
| 0045184 | |
| 0044419 | |
| 0043518 | |
| 0071157 | |
| 0000122 | |
| 0008284 | |
| 0045931 | |
| 0032436 | |
| 0006461 | |
| 0031648 | |
| 0034504 | |
| 0016567 | |
| 0042787 | |
| 0042176 | |
| 0007089 | |
| 0005737 | |
| 0005829 | |
| 0030666 | |
| 0005626 | |
| 0005622 | |
| 0016604 | |
| 0005730 | |
| 0005654 | |
| 0005634 | |
| 0005886 | |
| 0043234 | |
| 0042975 | |
| 0010843 | |
| 0043066 | |
| 0043154 | |
| 0010629 | |
| 0010955 | |
| 0045787 | |
| 0010628 | |
| 0046827 | |
| 0030163 | |
| 0005625 | |
| 0045202 | |
| 0071494 | |
| 0071229 | |
| 0071312 | |
| 0071236 | |
| 0071391 | |
| 0071363 | |
| 0070301 | |
| 0071407 | |
| 0071310 | |
| 0071375 | |
| 0071445 | |
| 0071301 | |
| 0009743 | |
| 0042220 | |
| 0042493 | |
| 0045472 | |
| 0010039 | |
| 0032026 | |
| 0043278 | |
| 0048545 | |
| 0009636 |
| Rat chromosome position | 7q22 |
|---|
| PIR ID | S15349 |
|---|---|
| S24354 |
| Unigene ID | Hs.484551 |
|---|---|
| Mm.22670 | |
| Mm.447669 | |
| Rn.91829 |
| KEGG ID | hsa:4193 |
|---|---|
| mmu:17246 | |
| rno:314856 |
| EC Number | 6.3.2.- |
|---|
| Swiss-Prot ID | MDM2_MOUSE |
|---|---|
| MDM2_HUMAN | |
| Q91XK7_MOUSE | |
| A6NL51_HUMAN | |
| A7UKX7_HUMAN | |
| A7UKX9_HUMAN |
| Cell Localization | Nucleus |
|---|---|
| nucleoplasm | |
| Cytoplasm | |
| nucleolus |
| IPI ID | IPI00129226 |
|---|---|
| IPI00323397 | |
| IPI00103723 | |
| IPI00103724 | |
| IPI00218551 | |
| IPI00218552 | |
| IPI00218553 | |
| IPI00295694 | |
| IPI00410597 | |
| IPI00472971 | |
| IPI00789663 | |
| IPI00940767 | |
| IPI00944540 | |
| IPI00025490 | |
| IPI00384422 | |
| IPI00384427 | |
| IPI00386541 | |
| IPI00791322 | |
| IPI00748589 | |
| IPI00386544 | |
| IPI00472854 | |
| IPI00168602 | |
| IPI00383012 | |
| IPI00041320 | |
| IPI00798285 | |
| IPI00472747 | |
| IPI00794114 | |
| IPI00386543 | |
| IPI00386041 | |
| IPI00853596 | |
| IPI00830459 | |
| IPI00766971 |
| Homologene ID | 1793 |
|---|
| RGD ID | 1305332 |
|---|
| MGI ID | 96952 |
|---|