Protein Mdm4

URN	urn:agi-llid:4194
Total Entities	0
Connectivity	107
Name	Mdm4
Description	Mdm4 p53 binding protein homolog (mouse)
Notes	The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2

Ariadne Ontology	MDM2-4

GO Cellular Component	intracellular
	nucleus

GO Biological Process	cell proliferation
	negative regulation of cell cycle arrest
	G0 to G1 transition
	negative regulation of transcription from RNA polymerase II promoter
	negative regulation of cell proliferation
	negative regulation of apoptotic process
	positive regulation of cell proliferation
	cellular response to hypoxia
	apoptotic process
	negative regulation of protein catabolic process
	protein stabilization
	protein complex assembly

Pathway	p53 signaling pathway
	p53 signaling pathway

Group	MDM2-4
	cell proliferation
	negative regulation of cell cycle arrest
	G0 to G1 transition
	negative regulation of transcription from RNA polymerase II promoter
	negative regulation of cell proliferation
	negative regulation of apoptotic process
	positive regulation of cell proliferation
	cellular response to hypoxia
	apoptotic process
	negative regulation of protein catabolic process
	protein stabilization
	protein complex assembly
	enzyme binding
	metal ion binding
	zinc ion binding
	intracellular
	nucleus

MedScan ID	4194

Hugo ID	6974

Human chromosome position	1q32

Alias	HDMX
	MDMX
	MRP1
	RP11-430C7.1
	protein Mdm4
	protein Mdmx
	MDM4-related protein 1
	mdm2-like p53-binding protein
	double minute 4, human homolog of; p53-binding protein
	Mdm4, transformed 3T3 cell double minute 4, p53 binding protein
	C85810
	AA414968
	AL023055
	AU018793
	AU021806
	4933417N07Rik
	double minute 4 protein
	p53-binding protein Mdm4
	double minute 4 homolog
	transformed mouse 3T3 cell double minute 4
	Mdm4 p53 binding protein homolog (mouse)
	MGC132766
	mouse double minute 4 homolog
	MDM4
	transformed mouse 3T3 cell double minute IV
	LOC263724
	4933417N07
	DKFZp781B1423
	p53-binding protein
	Mdm2-like p53-binding protein
	RIKEN cDNA 4933417N07 gene
	C85810s
	Mdmx protein
	expressed sequence C85810

OMIM ID	602704

PIR ID	S71955

Cell Localization	Nucleus
	Cytoplasm

Mouse chromosome position	1 70.0 cM

Rat chromosome position	13q13

Homologene ID	1794

MGI ID	107934

RGD ID	1309306

Primary Cell Localization	Cytoplasm