Elsevier Inc. Mdm2 ---| Tp53 Mdm2 ---- Tp53 Tp53 ---> Mdm2 Mdm4 ---- Tp53 Mdm4 p53, Mdm2 acetylation ---> Tp53 p53 methylation ---> Tp53 ataxia telangiectasia-mutated (ATM) signaling pathway --+> Tp53 Tp53 <--> non-coding RNAs - p53 targets, regulators, effectors non-coding RNAs - p53 targets, regulators, effectors RNA polymerase II transcription initiation pathway Tp53 --+> RNA polymerase II transcription pathway p53 targets Tp53 --+> intrinsic apoptotic pathway Tp53 --+> cell cycle arrest Tp53 --+> senescence Tp53 ---> p53 targets Tp53 ---> non-coding RNAs - p53 targets, regulators, effectors p53-dependent histone acetylation RNA polymerase II transcription pathway p53-dependent histone acetylation ---- Tp53 Tp53 exogenous stress NO p53 binding partners p53 regulators p53, Mdm2 acetylation ---| Mdm2 p53, Mdm2 phosphorylation ---> Mdm2 p53, Mdm2 phosphorylation ---> Tp53 ataxia telangiectasia-mutated (ATM) signaling pathway ---> p53, Mdm2 phosphorylation p53, Mdm2 acetylation p53 methylation p53, Mdm2 phosphorylation intrinsic apoptotic pathway cell cycle arrest endogenous stress ataxia telangiectasia-mutated (ATM) signaling pathway Mdm4 ---| Tp53 exogenous stress --+> Tp53 p53 ubiquitination Mdm2 p53 binding partners ---- Tp53 Mdm2 ---- Mdm4 senescence endogenous stress --+> Tp53