| Name | Pde4d |
|---|---|
| Description | phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila) |
| Notes | The PDE4D gene is complex and has at least 9 different isoforms that encode functional proteins. These proteins degrade the second messenger cAMP, which is a key signal transduction molecule in multiple cell types, including vascular cells (Dominiczak and McBride, 2003 [PubMed 14517535]).[supplied by OMIM] |
| Owner | Public |
| URN | urn:agi-llid:5144 |
| Connectivity | 207 |
| LocusLink ID | 5144 |
|---|---|
| 238871 | |
| 24627 |
| OMIM ID | 600129 |
|---|---|
| 606799 |
| GO ID | 0004115 |
|---|---|
| 0004114 | |
| 0016787 | |
| 0046872 | |
| 0007165 | |
| 0005575 | |
| 0005813 | |
| 0005737 | |
| 0005856 | |
| 0005626 | |
| 0016020 | |
| 0005625 | |
| 0003824 | |
| 0006198 | |
| 0006939 | |
| 0004112 | |
| 0007613 | |
| 0008277 |
| Hugo ID | 8783 |
|---|
| Human chromosome position | 5q12 |
|---|
| Unigene ID | Hs.117545 |
|---|---|
| Mm.434429 | |
| Mm.460932 | |
| Rn.95959 | |
| Rn.163460 |
| KEGG ID | hsa:5144 |
|---|---|
| mmu:238871 | |
| rno:24627 |
| Alias | DPDE3 |
|---|---|
| STRK1 | |
| HSPDE4D | |
| PDE4DN2 | |
| cAMP-specific phosphodiesterase 4D | |
| dunce-like phosphodiesterase E3 | |
| cAMP-specific phosphodiesterase PDE4D6 | |
| phosphodiesterase 4D, cAMP-specific (dunce | |
| 9630011N22Rik | |
| phosphodiesterase 4D, cAMP specific | |
| dunce | |
| cyclic AMP specific phosphodiesterase PDE4D5A | |
| phosphodiesterase 4D | |
| cAMP-specific phosphodiesterase PDE4D | |
| Phosphodiesterase 4D cAMP-specific (dunce | |
| cAMP-specific phosphodiesterase splice variant PDE4D8 | |
| cAMP-dependent 3',5'-cyclic phosphodiesterase 4D | |
| PDE43 | |
| Phosphodiesterase-4D, cAMP-specific | |
| Phosphodiesterase-4D, cAMP-specific (dunce (Drosophila)-homolog | |
| RIKEN cDNA 9630011N22 gene | |
| phosphodiesterase 4D, cAMP-specific (dunce -homolog phosphodies | |
| dunce -homolog phosphodiesterase E3 | |
| phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Dr | |
| Pde4d | |
| Phosphodiesterase-4D, cAMP-specific (dunce-homolog | |
| cyclic AMP phosphodiesterase | |
| similar to cAMP-specific phosphodiesterase | |
| Stroke, susceptibility to, I | |
| Stroke, susceptibility to, 1 | |
| STRK I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| Mouse chromosome position | 13 D2.1-D2.2 |
|---|
| Rat chromosome position | 2q16 |
|---|
| Cell Localization | Cytoplasm |
|---|
| Homologene ID | 710 |
|---|
| Pathway | vasopressin signaling pathway via receptor type 2 |
|---|---|
| vasopressin signaling pathway - first |
| MGI ID | 99555 |
|---|
| Ariadne Ontology | Purine metabolism |
|---|
| RGD ID | 3281 |
|---|
| GO Molecular Function | catalytic activity |
|---|---|
| metal ion binding | |
| hydrolase activity | |
| cyclic-nucleotide phosphodiesterase activity | |
| 3',5'-cyclic-nucleotide phosphodiesterase activity | |
| 3',5'-cyclic-AMP phosphodiesterase activity |
| GO Cellular Component | cellular_component |
|---|---|
| membrane | |
| soluble fraction | |
| insoluble fraction | |
| cytoplasm | |
| centrosome | |
| cytoskeleton |
| GO Biological Process | regulation of G-protein coupled receptor protein signaling pathway |
|---|---|
| signal transduction | |
| cAMP catabolic process | |
| memory | |
| smooth muscle contraction |
| Group | cellular_component |
|---|---|
| membrane | |
| soluble fraction | |
| insoluble fraction | |
| cytoplasm | |
| centrosome | |
| cytoskeleton | |
| catalytic activity | |
| metal ion binding | |
| hydrolase activity | |
| cyclic-nucleotide phosphodiesterase activity | |
| 3',5'-cyclic-nucleotide phosphodiesterase activity | |
| 3',5'-cyclic-AMP phosphodiesterase activity | |
| regulation of G-protein coupled receptor protein signaling pathway | |
| signal transduction | |
| cAMP catabolic process | |
| memory | |
| smooth muscle contraction | |
| Purine metabolism |