| Name | Vamp2 |
|---|---|
| Description | vesicle-associated membrane protein 2 (synaptobrevin 2) |
| Notes | The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. |
| Owner | Public |
| URN | urn:agi-llid:6844 |
| Connectivity | 179 |
| LocusLink ID | 6844 |
|---|---|
| 22318 | |
| 24803 |
| OMIM ID | 185881 |
|---|
| GO ID | 0005515 |
|---|---|
| 0016192 | |
| 0030054 | |
| 0031410 | |
| 0005887 | |
| 0016020 | |
| 0045202 | |
| 0019717 | |
| 0000149 | |
| 0005516 | |
| 0005543 | |
| 0017156 | |
| 0006944 | |
| 0017157 | |
| 0016079 | |
| 0016021 | |
| 0030141 | |
| 0008021 | |
| 0030672 | |
| 0042589 | |
| 0017022 | |
| 0017075 | |
| 0031201 |
| Hugo ID | 12643 |
|---|
| Human chromosome position | 17p13.1 |
|---|
| Unigene ID | Hs.25348 |
|---|---|
| Mm.28643 | |
| Rn.12939 |
| KEGG ID | hsa:6844 |
|---|---|
| mmu:22318 | |
| rno:24803 |
| Alias | SYB2 |
|---|---|
| VAMP-2 | |
| FLJ11460 | |
| vesicle-associated membrane protein 2 (synaptobrevin 2) | |
| synaptobrevin 2 | |
| vesicle associated membrane protein 2 | |
| Syb-2 | |
| RP23-26L6.8 | |
| vesicle-associated membrane protein 2 | |
| synaptobrevin II | |
| vesicle-associated membrane 2 | |
| SYB | |
| RATVAMPB | |
| RATVAMPIR | |
| Vesicle-associated membrane protein (synaptobrevin 2) | |
| Synaptobrevin 2 (vesicle-associated membrane protein VAMP-2) | |
| Vamp2 | |
| Vesicle-associated membrane protein II | |
| vesicle-associated membrane protein VAMP-2 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| Mouse chromosome position | 11 B3 |
|---|
| Rat chromosome position | 10q24 |
|---|
| Cell Localization | Golgi |
|---|---|
| Lysosome |
| Homologene ID | 7591 |
|---|
| Pathway | insulin responsive facilitative sugar transporter mediated glucose transport pathway |
|---|---|
| insulin secretion pathway | |
| altered insulin responsive facilitative sugar transporter mediated glucose transport pathway | |
| altered insulin secretion pathway | |
| vasopressin signaling pathway via receptor type 2 | |
| vasopressin signaling pathway - first |
| MGI ID | 1313277 |
|---|
| Ariadne Ontology | Endosomal recycling |
|---|---|
| Vesicular secretory pathway |
| RGD ID | 3949 |
|---|
| GO Molecular Function | protein binding |
|---|---|
| phospholipid binding | |
| calmodulin binding | |
| SNARE binding | |
| myosin binding | |
| syntaxin-1 binding |
| GO Cellular Component | synapse |
|---|---|
| membrane | |
| synaptosome | |
| cytoplasmic vesicle | |
| secretory granule | |
| synaptic vesicle | |
| synaptic vesicle membrane | |
| zymogen granule membrane | |
| SNARE complex | |
| integral to membrane | |
| integral to plasma membrane | |
| cell junction |
| GO Biological Process | regulation of exocytosis |
|---|---|
| synaptic vesicle exocytosis | |
| calcium ion-dependent exocytosis | |
| membrane fusion | |
| vesicle-mediated transport |
| Group | synapse |
|---|---|
| membrane | |
| synaptosome | |
| cytoplasmic vesicle | |
| secretory granule | |
| synaptic vesicle | |
| synaptic vesicle membrane | |
| zymogen granule membrane | |
| SNARE complex | |
| integral to membrane | |
| integral to plasma membrane | |
| cell junction | |
| protein binding | |
| phospholipid binding | |
| calmodulin binding | |
| SNARE binding | |
| myosin binding | |
| syntaxin-1 binding | |
| regulation of exocytosis | |
| synaptic vesicle exocytosis | |
| calcium ion-dependent exocytosis | |
| membrane fusion | |
| vesicle-mediated transport | |
| Endosomal recycling | |
| Vesicular secretory pathway |