| Name | Sipa1 |
|---|---|
| Description | signal-induced proliferation-associated gene 1 |
| Notes | The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. |
| Owner | Public |
| URN | urn:agi-llid:6494 |
| Connectivity | 83 |
| LocusLink ID | 6494 |
|---|---|
| 20469 | |
| 361710 |
| OMIM ID | 602180 |
|---|
| GO ID | 0005096 |
|---|---|
| 0046582 | |
| 0005515 | |
| 0008283 | |
| 0007010 | |
| 0007242 | |
| 0007162 | |
| 0045786 | |
| 0030308 | |
| 0051056 | |
| 0005737 | |
| 0005622 | |
| 0016020 | |
| 0005634 | |
| 0051726 |
| Hugo ID | 10885 |
|---|
| Human chromosome position | 11q13 |
|---|
| Unigene ID | Hs.530477 |
|---|---|
| Mm.3072 | |
| Rn.24935 |
| KEGG ID | hsa:6494 |
|---|---|
| mmu:20469 | |
| rno:361710 |
| Alias | SPA1 |
|---|---|
| MGC17037 | |
| MGC102688 | |
| signal-induced proliferation-associated protein 1 | |
| p130 SPA-1 | |
| GTPase-activating protein Spa-1 | |
| SPA-1 | |
| KIAA4074 | |
| mKIAA4074 | |
| signal-induced proliferation associated gene 1 | |
| signal-induced proliferation-associated gene 1 | |
| SIPA1 | |
| SPA I | |
| SIPA I | |
| p130 SPA I | |
| GTPase-activating protein Spa I | |
| signal-induced proliferation-associated gene I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| Mouse chromosome position | 19 2.0 cM |
|---|
| Rat chromosome position | 1q43 |
|---|
| Homologene ID | 7940 |
|---|
| Pathway | vasopressin signaling pathway via receptor type 2 |
|---|---|
| vasopressin signaling pathway - first |
| MGI ID | 107576 |
|---|
| RGD ID | 1303184 |
|---|
| GO Molecular Function | protein binding |
|---|---|
| GTPase activator activity | |
| Rap GTPase activator activity |
| GO Cellular Component | membrane |
|---|---|
| intracellular | |
| cytoplasm | |
| nucleus |
| GO Biological Process | negative regulation of cell adhesion |
|---|---|
| negative regulation of cell growth | |
| negative regulation of cell cycle | |
| regulation of cell cycle | |
| regulation of small GTPase mediated signal transduction | |
| cell proliferation | |
| intracellular signaling cascade | |
| cytoskeleton organization and biogenesis |
| Group | membrane |
|---|---|
| intracellular | |
| cytoplasm | |
| nucleus | |
| protein binding | |
| GTPase activator activity | |
| Rap GTPase activator activity | |
| negative regulation of cell adhesion | |
| negative regulation of cell growth | |
| negative regulation of cell cycle | |
| regulation of cell cycle | |
| regulation of small GTPase mediated signal transduction | |
| cell proliferation | |
| intracellular signaling cascade | |
| cytoskeleton organization and biogenesis |