| Name | Snap23 |
|---|---|
| Description | synaptosomal-associated protein, 23kDa |
| Notes | Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene. |
| Owner | Public |
| URN | urn:agi-llid:8773 |
| Connectivity | 129 |
| LocusLink ID | 8773 |
|---|---|
| 20619 | |
| 64630 |
| OMIM ID | 602534 |
|---|
| GO ID | 0005515 |
|---|---|
| 0006944 | |
| 0006892 | |
| 0015031 | |
| 0006903 | |
| 0030054 | |
| 0005886 | |
| 0045202 | |
| 0019717 | |
| 0005484 | |
| 0008565 | |
| 0006886 | |
| 0006810 | |
| 0007033 | |
| 0016020 | |
| 0005792 | |
| 0030133 | |
| 0031201 | |
| 0031410 |
| Hugo ID | 11131 |
|---|
| Human chromosome position | 15q15.1 |
|---|
| Unigene ID | Hs.511149 |
|---|---|
| Mm.245715 | |
| Rn.14789 |
| KEGG ID | hsa:8773 |
|---|---|
| mmu:20619 | |
| rno:64630 |
| Alias | SNAP23A |
|---|---|
| SNAP23B | |
| HsT17016 | |
| synaptosomal-associated protein 23 | |
| Sndt | |
| 23kDa | |
| Syndet | |
| SNAP-23 | |
| AA408749 | |
| RP23-158L6.2 | |
| synaptosomal-associated protein, 23kD | |
| synaptosomal-associated protein 23 kD | |
| synaptosomal-associated protein, 23 kD | |
| SNAP23s | |
| synaptosomal-associated protein 23 isoform SNAP23B | |
| synaptosomal-associated protein, 23kDa | |
| Vesicle-membrane fusion protein SNAP-23 | |
| 23 kDa synaptosomal-associated protein | |
| SNAP23 | |
| synaptosomal-associated protein 23 isoform SNAP23A |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| Mouse chromosome position | 2 61.8 cM |
|---|
| Rat chromosome position | 3 |
|---|
| Cell Localization | Golgi |
|---|---|
| Plasma membrane |
| Homologene ID | 37857 |
|---|
| Pathway | insulin responsive facilitative sugar transporter mediated glucose transport pathway |
|---|---|
| altered insulin responsive facilitative sugar transporter mediated glucose transport pathway | |
| vasopressin signaling pathway via receptor type 2 | |
| vasopressin signaling pathway - first |
| MGI ID | 109356 |
|---|
| Ariadne Ontology | Transcytosis |
|---|---|
| Vesicular secretory pathway |
| RGD ID | 620221 |
|---|
| GO Molecular Function | protein binding |
|---|---|
| SNAP receptor activity | |
| protein transporter activity |
| GO Cellular Component | synapse |
|---|---|
| membrane | |
| synaptosome | |
| microsome | |
| cytoplasmic vesicle | |
| transport vesicle | |
| plasma membrane | |
| SNARE complex | |
| cell junction |
| GO Biological Process | vesicle targeting |
|---|---|
| intracellular protein transport | |
| post-Golgi vesicle-mediated transport | |
| membrane fusion | |
| vacuole organization and biogenesis | |
| transport | |
| protein transport |
| Group | synapse |
|---|---|
| membrane | |
| synaptosome | |
| microsome | |
| cytoplasmic vesicle | |
| transport vesicle | |
| plasma membrane | |
| SNARE complex | |
| cell junction | |
| protein binding | |
| SNAP receptor activity | |
| protein transporter activity | |
| vesicle targeting | |
| intracellular protein transport | |
| post-Golgi vesicle-mediated transport | |
| membrane fusion | |
| vacuole organization and biogenesis | |
| transport | |
| protein transport | |
| Transcytosis | |
| Vesicular secretory pathway |