| URN | urn:agi-llid:207 |
|---|---|
| Connectivity | 3235 |
| Name | Akt1 |
| Description | thymoma viral proto-oncogene 1 |
| Notes | inhibits JUN kinase activation and mediates inhibition of apoptosis [RGD] |
| Pathway | PDGFR -> FOXO3A signaling |
|---|---|
| VEGFR -> FOXO3A signaling | |
| HGFR -> FOXO3A signaling | |
| ErythropoietinR -> FOXO3A signaling | |
| NTRK -> FOXO/MYCN signaling | |
| DDR1 -> NF-kB signaling | |
| AngiopoietinR -> FOXO signaling | |
| GDNF -> HSF1 signaling | |
| InsulinR -> CTNNB/FOXA/FOXO signaling | |
| IGF1R -> CEBPA/FOXO1A signaling | |
| InsulinR -> ELK-SRF/SREBF signaling | |
| FibronectinR -> NF-kB signaling | |
| FibronectinR -> CTNNB signaling | |
| ICAM2 -> CTNNB/FOXO/STAT3 signaling | |
| MacrophageR -> CEBPB/NF-kB signaling | |
| ThrombopoietinR -> SPI1 signaling | |
| GHR -> NF-kB signaling | |
| ErythropoietinR -> NF-kB signaling | |
| EGFR/ERBB2 -> HIF1A signaling | |
| VEGFR -> CTNNB signaling | |
| IL12R -> NF-kB/NFATC signaling | |
| IL15R -> NF-kB/NFATC signaling | |
| IL7R -> FOXO/NF-kB signaling | |
| TNFRSF5/13B -> NFATC1 signaling | |
| CD19 -> NF-kB signaling | |
| ThrombinR -> NF-kB signaling | |
| DopamineR2 -> NF-kB signaling | |
| AdenosineR -> NF-kB signaling | |
| PTAFR -> NF-kB signaling | |
| AdrenergicRb -> STAT3 signaling | |
| FSHR -> FOXO1A signaling | |
| Notch -> NF-kB signaling | |
| AGER -> NF-kB signaling | |
| TLR1/2/6 -> NF-kB signaling | |
| Apoptosis | |
| CD38 -> NF-kB signaling | |
| phosphatidylinositol 3-kinase-Akt signaling pathway | |
| phosphatidylinositol 3-kinase-Akt signaling pathway | |
| non-small cell lung cancer pathway |
| GO Molecular Function | nucleotide binding |
|---|---|
| transferase activity | |
| nitric-oxide synthase regulator activity | |
| enzyme binding | |
| ATP binding | |
| phosphatidylinositol-3,4-bisphosphate binding | |
| phosphatidylinositol-3,4,5-trisphosphate binding | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity |
| GO Cellular Component | membrane |
|---|---|
| soluble fraction | |
| plasma membrane | |
| lamellipodium | |
| cytoplasm | |
| cytosol | |
| nucleoplasm | |
| spindle | |
| cytoskeleton | |
| nucleus | |
| microtubule cytoskeleton |
| GO Biological Process | cell projection organization |
|---|---|
| transport | |
| maternal placenta development | |
| anagen | |
| germ cell development | |
| nervous system development | |
| regulation of neuron projection development | |
| labyrinthine layer blood vessel development | |
| glycogen cell development involved in embryonic placenta development | |
| positive regulation of fat cell differentiation | |
| signal transduction | |
| positive regulation of cell growth | |
| positive regulation of establishment of protein localization in plasma membrane | |
| positive regulation of cyclin-dependent protein kinase activity involved in G1-S | |
| negative regulation of JNK cascade | |
| regulation of cell migration | |
| protein kinase B signaling cascade | |
| regulation of translation | |
| positive regulation of cellular protein metabolic process | |
| negative regulation of fatty acid beta-oxidation | |
| positive regulation of proteasomal ubiquitin-dependent protein catabolic process | |
| positive regulation of glucose metabolic process | |
| positive regulation of glycogen biosynthetic process | |
| positive regulation of nitric oxide biosynthetic process | |
| regulation of glycogen biosynthetic process | |
| negative regulation of protein kinase activity | |
| activation of pro-apoptotic gene products | |
| negative regulation of apoptosis | |
| anti-apoptosis | |
| regulation of survival gene product expression | |
| neuron migration | |
| translation | |
| nitric oxide biosynthetic process | |
| glycogen biosynthetic process | |
| glucose metabolic process | |
| glycogen metabolic process | |
| protein modification process | |
| protein amino acid phosphorylation | |
| protein ubiquitination | |
| protein amino acid autophosphorylation | |
| peptidyl-serine phosphorylation | |
| apoptotic mitochondrial changes | |
| cellular response to insulin stimulus | |
| insulin receptor signaling pathway | |
| apoptosis | |
| activation-induced cell death of T cells | |
| response to food | |
| response to heat | |
| response to fluid shear stress | |
| response to hormone stimulus | |
| inflammatory response | |
| response to UV-A | |
| regulation of protein localization | |
| negative regulation of plasma membrane long-chain fatty acid transport | |
| positive regulation of lipid biosynthetic process | |
| positive regulation of sodium ion transport | |
| positive regulation of glucose import | |
| carbohydrate metabolic process | |
| protein catabolic process | |
| carbohydrate transport | |
| protein import into nucleus, translocation | |
| glucose transport | |
| intracellular signaling pathway | |
| G-protein coupled receptor protein signaling pathway | |
| insulin-like growth factor receptor signaling pathway | |
| negative regulation of cell size | |
| positive regulation of nitric-oxide synthase activity |
| Ariadne Ontology | AKT |
|---|---|
| Oncogenes |
| Group | AKT |
|---|---|
| Oncogenes | |
| cell projection organization | |
| transport | |
| maternal placenta development | |
| anagen | |
| germ cell development | |
| nervous system development | |
| regulation of neuron projection development | |
| labyrinthine layer blood vessel development | |
| glycogen cell development involved in embryonic placenta development | |
| positive regulation of fat cell differentiation | |
| signal transduction | |
| positive regulation of cell growth | |
| positive regulation of establishment of protein localization in plasma membrane | |
| positive regulation of cyclin-dependent protein kinase activity involved in G1-S | |
| negative regulation of JNK cascade | |
| regulation of cell migration | |
| protein kinase B signaling cascade | |
| regulation of translation | |
| positive regulation of cellular protein metabolic process | |
| negative regulation of fatty acid beta-oxidation | |
| positive regulation of proteasomal ubiquitin-dependent protein catabolic process | |
| positive regulation of glucose metabolic process | |
| positive regulation of glycogen biosynthetic process | |
| positive regulation of nitric oxide biosynthetic process | |
| regulation of glycogen biosynthetic process | |
| negative regulation of protein kinase activity | |
| activation of pro-apoptotic gene products | |
| negative regulation of apoptosis | |
| anti-apoptosis | |
| regulation of survival gene product expression | |
| neuron migration | |
| translation | |
| nitric oxide biosynthetic process | |
| glycogen biosynthetic process | |
| glucose metabolic process | |
| glycogen metabolic process | |
| protein modification process | |
| protein amino acid phosphorylation | |
| protein ubiquitination | |
| protein amino acid autophosphorylation | |
| peptidyl-serine phosphorylation | |
| apoptotic mitochondrial changes | |
| cellular response to insulin stimulus | |
| insulin receptor signaling pathway | |
| apoptosis | |
| activation-induced cell death of T cells | |
| response to food | |
| response to heat | |
| response to fluid shear stress | |
| response to hormone stimulus | |
| inflammatory response | |
| response to UV-A | |
| regulation of protein localization | |
| negative regulation of plasma membrane long-chain fatty acid transport | |
| positive regulation of lipid biosynthetic process | |
| positive regulation of sodium ion transport | |
| positive regulation of glucose import | |
| carbohydrate metabolic process | |
| protein catabolic process | |
| carbohydrate transport | |
| protein import into nucleus, translocation | |
| glucose transport | |
| intracellular signaling pathway | |
| G-protein coupled receptor protein signaling pathway | |
| insulin-like growth factor receptor signaling pathway | |
| negative regulation of cell size | |
| positive regulation of nitric-oxide synthase activity | |
| nucleotide binding | |
| transferase activity | |
| nitric-oxide synthase regulator activity | |
| enzyme binding | |
| ATP binding | |
| phosphatidylinositol-3,4-bisphosphate binding | |
| phosphatidylinositol-3,4,5-trisphosphate binding | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| membrane | |
| soluble fraction | |
| plasma membrane | |
| lamellipodium | |
| cytoplasm | |
| cytosol | |
| nucleoplasm | |
| spindle | |
| cytoskeleton | |
| nucleus | |
| microtubule cytoskeleton |
| MedScan ID | 207 |
|---|
| Hugo ID | 391 |
|---|
| Human chromosome position | 14q32.32 |
|---|
| LocusLink ID | 207 |
|---|---|
| 11651 | |
| 24185 | |
| 50586 |
| Alias | AKT |
|---|---|
| PKB | |
| RAC | |
| PRKBA | |
| MGC99656 | |
| PKB-ALPHA | |
| RAC-ALPHA | |
| RAC-alpha serine/threonine-protein kinase | |
| RAC-PK-alpha | |
| protein kinase B | |
| proto-oncogene c-Akt | |
| rac protein kinase alpha | |
| PKB/Akt | |
| PKBalpha | |
| AKT1 kinase | |
| OTTMUSP00000022944 | |
| OTTMUSP00000022947 | |
| OTTMUSP00000022949 | |
| protein kinase B-alpha | |
| related to A and C kinases | |
| thymoma viral proto-oncogene 1 | |
| RAC protein kinase alpha RAC-PK alpha | |
| murine thymoma viral (v-akt) oncogene homolog 1 | |
| 6.1a protein | |
| Akt I | |
| Akt/PKB | |
| Akt/PKBs | |
| Akt1 | |
| AKTI | |
| C6.1A | |
| C-AKT | |
| LOC217879 | |
| LOC268604 | |
| MGC29148 | |
| Murine thymoma viral (v-akt) oncogene homolog I | |
| PKB alpha | |
| PKB/Akts | |
| protein kinase B alpha | |
| RAC-alpha serine/threonine kinase | |
| serine/threonine protein kinase B | |
| thymoma viral proto-oncogene | |
| thymoma viral proto-oncogene 1; thymoma viral proto-oncogene | |
| thymoma viral proto-oncogene I | |
| v-akt murine thymoma viral oncogene homolog 1 | |
| v-akt murine thymoma viral oncogene homolog I | |
| murine thymoma viral (v-akt) oncogene homolog-1 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 164730 |
|---|---|
| 114480 | |
| 114500 | |
| 604370 | |
| 181500 |
| Mouse chromosome position | 12 57.0 cM |
|---|
| GO ID | 0005524 |
|---|---|
| 0019899 | |
| 0016301 | |
| 0030235 | |
| 0000166 | |
| 0005547 | |
| 0043325 | |
| 0004672 | |
| 0004674 | |
| 0016740 | |
| 0007186 | |
| 0008633 | |
| 0006924 | |
| 0042640 | |
| 0006916 | |
| 0008637 | |
| 0005975 | |
| 0008643 | |
| 0030030 | |
| 0032869 | |
| 0007281 | |
| 0015758 | |
| 0060709 | |
| 0006954 | |
| 0008286 | |
| 0048009 | |
| 0023034 | |
| 0060716 | |
| 0001893 | |
| 0046329 | |
| 0043066 | |
| 0045792 | |
| 0031999 | |
| 0010748 | |
| 0006469 | |
| 0007399 | |
| 0001764 | |
| 0006809 | |
| 0018105 | |
| 0030307 | |
| 0032270 | |
| 0031659 | |
| 0090004 | |
| 0045600 | |
| 0046326 | |
| 0010907 | |
| 0045725 | |
| 0046889 | |
| 0045429 | |
| 0051000 | |
| 0032436 | |
| 0010765 | |
| 0046777 | |
| 0006468 | |
| 0030163 | |
| 0000060 | |
| 0043491 | |
| 0006464 | |
| 0016567 | |
| 0030334 | |
| 0005979 | |
| 0010975 | |
| 0032880 | |
| 0045884 | |
| 0006417 | |
| 0070141 | |
| 0034405 | |
| 0032094 | |
| 0009408 | |
| 0009725 | |
| 0007165 | |
| 0005737 | |
| 0005829 | |
| 0030027 | |
| 0015630 | |
| 0005654 | |
| 0005634 | |
| 0005886 | |
| 0005625 | |
| 0005819 | |
| 0006915 | |
| 0006006 | |
| 0005978 | |
| 0005977 | |
| 0006412 | |
| 0006810 | |
| 0016020 | |
| 0005856 | |
| 0042802 | |
| 0005351 | |
| 0001568 | |
| 0007242 | |
| 0001890 | |
| 0040018 | |
| 0070201 | |
| 0005515 | |
| 0006445 | |
| 0004713 | |
| 0000074 | |
| 0050875 | |
| 0004702 |
| Rat chromosome position | 6q32 |
|---|
| Swiss-Prot Accession | B0LPE5 |
|---|---|
| P31749 | |
| B3KVH4 | |
| Q9BV07 | |
| Q6GSA6 | |
| P31750 | |
| Q8BS26 | |
| P47196 | |
| Q9BWB6 | |
| Q6ZMW5 |
| PIR ID | A39360 |
|---|---|
| JC2437 |
| Unigene ID | Hs.525622 |
|---|---|
| Mm.6645 | |
| Rn.11422 |
| KEGG ID | hsa:207 |
|---|---|
| mmu:11651 | |
| rno:24185 |
| EC Number | 2.7.11.1 |
|---|---|
| 2.7.1.37 |
| Swiss-Prot ID | AKT1_HUMAN |
|---|---|
| AKT1_RAT | |
| B0LPE5_HUMAN | |
| B3KVH4_HUMAN | |
| Q6GSA6_MOUSE |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus | |
| Cell membrane |
| IPI ID | IPI00012866 |
|---|---|
| IPI00212844 | |
| IPI00323969 | |
| IPI00556735 |
| Homologene ID | 3785 |
|---|
| RGD ID | 2081 |
|---|
| MGI ID | 87986 |
|---|
| Source | Curated |
|---|
| KEGG pathway | Insulin signaling pathway |
|---|---|
| B cell receptor signaling pathway | |
| Apoptosis | |
| Jak-STAT signaling pathway | |
| Focal adhesion | |
| Tight junction | |
| Toll-like receptor signaling pathway | |
| MAPK signaling pathway | |
| T cell receptor signaling pathway | |
| Adipocytokine signaling pathway |