| URN | urn:agi-llid:207 |
|---|---|
| Total Entities | 0 |
| Connectivity | 6087 |
| Name | Akt1 |
| Description | thymoma viral proto-oncogene 1 |
| Notes | inhibits JUN kinase activation and mediates inhibition of apoptosis [RGD] |
| Ariadne Ontology | AKT |
|---|---|
| Oncogenes | |
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | enzyme binding |
|---|---|
| protein kinase binding | |
| protein kinase C binding | |
| nucleotide binding | |
| ATP binding | |
| phospholipid binding | |
| phosphatidylinositol-3,4,5-trisphosphate binding | |
| phosphatidylinositol-3,4-bisphosphate binding | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| nitric-oxide synthase regulator activity |
| GO Cellular Component | membrane |
|---|---|
| nucleoplasm | |
| spindle | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| microtubule cytoskeleton | |
| nucleus | |
| lamellipodium |
| GO Biological Process | cell proliferation |
|---|---|
| regulation of G1-S transition checkpoint | |
| germ cell development | |
| positive regulation of cyclin-dependent protein kinase activity involved in G1-S | |
| negative regulation of JNK cascade | |
| negative regulation of release of cytochrome c from mitochondria | |
| signal transduction | |
| intracellular signal transduction | |
| protein kinase B signaling cascade | |
| phosphatidylinositol-mediated signaling | |
| G-protein coupled receptor signaling pathway | |
| nerve growth factor receptor signaling pathway | |
| fibroblast growth factor receptor signaling pathway | |
| insulin receptor signaling pathway | |
| insulin-like growth factor receptor signaling pathway | |
| epidermal growth factor receptor signaling pathway | |
| positive regulation of cell growth | |
| negative regulation of fatty acid beta-oxidation | |
| positive regulation of proteasomal ubiquitin-dependent protein catabolic process | |
| positive regulation of cellular protein metabolic process | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of glycogen biosynthetic process | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of protein phosphorylation | |
| positive regulation of peptidyl-serine phosphorylation | |
| positive regulation of glucose metabolic process | |
| negative regulation of protein kinase activity | |
| regulation of glycogen biosynthetic process | |
| regulation of translation | |
| positive regulation of sequence-specific DNA binding transcription factor activity | |
| negative regulation of plasma membrane long-chain fatty acid transport | |
| negative regulation of apoptotic process | |
| positive regulation of establishment of protein localization to plasma membrane | |
| T cell costimulation | |
| positive regulation of blood vessel endothelial cell migration | |
| positive regulation of fat cell differentiation | |
| positive regulation of apoptotic process | |
| regulation of neuron projection development | |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | |
| regulation of cell migration | |
| cell differentiation | |
| osteoblast differentiation | |
| mammary gland epithelial cell differentiation | |
| striated muscle cell differentiation | |
| glycogen cell differentiation involved in embryonic placenta development | |
| platelet activation | |
| RNA metabolic process | |
| mRNA metabolic process | |
| glycogen biosynthetic process | |
| glycogen metabolic process | |
| nitric oxide biosynthetic process | |
| cellular protein modification process | |
| translation | |
| protein phosphorylation | |
| peptidyl-serine phosphorylation | |
| protein autophosphorylation | |
| protein ubiquitination | |
| phosphorylation | |
| peripheral nervous system myelin maintenance | |
| cellular response to growth factor stimulus | |
| cellular response to insulin stimulus | |
| cellular response to epidermal growth factor stimulus | |
| cellular response to hypoxia | |
| apoptotic process | |
| activation-induced cell death of T cells | |
| cell projection organization | |
| cytoskeleton organization | |
| apoptotic mitochondrial changes | |
| response to food | |
| response to hormone stimulus | |
| response to fluid shear stress | |
| response to heat | |
| inflammatory response | |
| response to UV-A | |
| positive regulation of vasoconstriction | |
| positive regulation of lipid biosynthetic process | |
| positive regulation of sodium ion transport | |
| positive regulation of glucose import | |
| positive regulation of nitric-oxide synthase activity | |
| regulation of nitric-oxide synthase activity | |
| regulation of protein localization | |
| multicellular organismal development | |
| aging | |
| anagen | |
| endocrine pancreas development | |
| maternal placenta development | |
| nervous system development | |
| labyrinthine layer blood vessel development | |
| blood coagulation | |
| transport | |
| protein import into nucleus, translocation | |
| carbohydrate transport | |
| glucose transport | |
| carbohydrate metabolic process | |
| glucose metabolic process | |
| protein catabolic process | |
| small molecule metabolic process | |
| gene expression | |
| nitric oxide metabolic process | |
| negative regulation of cell size | |
| glucose homeostasis |
| Pathway | Apoptosis |
|---|---|
| Actin Cytoskeleton Assembly | |
| Telomere Maintenance | |
| Cell Cycle | |
| Tight Junction Assembly (Occludin) | |
| Adherens Junction Assembly (Cadherins) | |
| PDGFR -> FOXO3A signaling | |
| VEGFR -> FOXO3A signaling | |
| HGFR -> FOXO3A signaling | |
| ErythropoietinR -> FOXO3A signaling | |
| TNFRSF5/13B -> NFATC1 signaling | |
| Notch -> NF-kB signaling | |
| TLR1/2/6 -> NF-kB signaling | |
| AGER -> NF-kB signaling | |
| EGFR/ERBB2 -> HIF1A signaling | |
| VEGFR -> CTNNB signaling | |
| InsulinR -> CTNNB/FOXA/FOXO signaling | |
| InsulinR -> ELK-SRF/SREBF signaling | |
| IGF1R -> CEBPA/FOXO1A signaling | |
| GDNF -> HSF1 signaling | |
| AngiopoietinR -> FOXO signaling | |
| NTRK -> FOXO/MYCN signaling | |
| DDR1 -> NF-kB signaling | |
| MacrophageR -> CEBPB/NF-kB signaling | |
| FibronectinR -> CTNNB signaling | |
| ICAM2 -> CTNNB/FOXO/STAT3 signaling | |
| FibronectinR -> NF-kB signaling | |
| CD19 -> NF-kB signaling | |
| IL7R -> FOXO/NF-kB signaling | |
| IL12R -> NF-kB/NFATC signaling | |
| IL15R -> NF-kB/NFATC signaling | |
| ThrombopoietinR -> SPI1 signaling | |
| ErythropoietinR -> NF-kB signaling | |
| GHR -> NF-kB signaling | |
| DopamineR2 -> NF-kB signaling | |
| PTAFR -> NF-kB signaling | |
| AdenosineR -> NF-kB signaling | |
| AdrenergicRb -> STAT3 signaling | |
| FSHR -> FOXO1A signaling | |
| ThrombinR -> NF-kB signaling | |
| CD38 -> NF-kB signaling | |
| Cyclosporine-Induced Nephrotoxicity | |
| Unfolded Protein Response | |
| Dexamethasone-Induced Diabetes | |
| Dexamethasone-Induced Osteoporosis | |
| Doxorubicin-Induced Cardiotoxicity | |
| Cytosolic Calcium Overload | |
| Clozapine-Induced Granulocytopenia | |
| Glutamate-Mediated Excitotoxicity | |
| Tamoxifen-Induced Endometrium Cancer | |
| Ritonavir-Induced Diabetes | |
| ROS in Angiotensin-Mediated Cardiovascular Remodeling and Hypertrophy | |
| TLR1/2/6 Expression Targets | |
| NGF/FOXO/MYCN/ELK-SRF Expression Targets | |
| BDNF Expression Targets | |
| NTF3 Expression Targets | |
| DLL1 Expression Targets | |
| DLL4 Expression Targets | |
| ADAM17 Expression Targets | |
| CD40LG/NF-kB/ELK-SRF/CREB/NFATC Expression Targets | |
| JAG1 Expression Targets | |
| TNFSF13B Expression Targets | |
| TNFSF10 Expression Targets | |
| TNF/STAT Expression Targets | |
| ICAM1 Expression Targets | |
| Fibrinogen Expression Targets | |
| Fibronectin Expression Targets | |
| CD21 Expression Targets | |
| PECAM1 Expression Targets | |
| CD19 Expression Targets | |
| CD81 Expression Targets | |
| IL12B Expression Targets | |
| IL15 Expression Targets | |
| IL7 Expression Targets | |
| Thrombopoietin/SPI1 Expression Targets | |
| Erythropoietin/NF-kB Expression Targets | |
| GH1-GHR/NF-kB/ELK-SRF/MYC Expression Targets | |
| PRL-GHR/NF-kB/ELK-SRF/MYC Expression Targets | |
| CSH1-GHR Expression Targets | |
| CCL3 Expression Targets | |
| CCL4 Expression Targets | |
| CCL5 Expression Targets | |
| IL8 Expression Targets | |
| Dopamine/Gi Expression Targets | |
| S100B Expression Targets | |
| S100P Expression Target | |
| HMGB1 Expression Targets | |
| TTR Expression Targets | |
| AREG/HIF1A Expression Targets | |
| EGF/HIF1A Expression Targets | |
| EREG/HIF1A Expression Target | |
| HBEGF/HIF1A Expression Targets | |
| NRG1/HIF1A Expression Target | |
| TGFA/HIF1A Expression Targets | |
| VEGFA/CTNNB/CTNND Expression Targets | |
| VEGFC/CTNNB Expression Target | |
| Collagen/NF-kB Expression Targets | |
| GDNF/HSF1 Expression Targets | |
| IGF2/CEBPA/FOXO1A Expression Targets | |
| CTGF/FOXO3A Expression Target | |
| Erythropoietin/FOXO3A Expression Targets | |
| Thrombopoietin/FOXO3A Expression Target | |
| AREG/FOXO3A Expression Target | |
| EGF/FOXO3A Expression Targets | |
| EREG/FOXO3A Expression Target | |
| HBEGF/FOXO3A Expression Target | |
| NRG1/FOXO3A Expression Targets | |
| TGFA/FOXO3A Expression Targets | |
| FGF2/FOXO3A Expression Targets | |
| FGF7/FOXO3A Expression Target | |
| FGF10/FOXO3A Expression Target | |
| CSF1/FOXO3A Expression Targets | |
| PDGFB/FOXO3A Expression Target | |
| VEGFA/FOXO3A Expression Targets | |
| HGF/FOXO3A Expression Targets | |
| PDGF/FOXO3A Expression Targets | |
| F2 -> STAT1/NF-kB Expression Targets | |
| PLG -> STAT1/NF-kB Expression Targets | |
| Adenosine Expression Targets | |
| PAF/Gq -> NF-kB Expression Targets | |
| Epinephrine/Gs Expression Targets | |
| Noradrenaline/Gs Expression Targets | |
| FSHR Expression Targets | |
| PDCD1/STAT Expression Targets | |
| PDCD1/ATF/CREB/CREBBP Expression Targets | |
| IGF1/CEBPA/FOXO1A Expression Targets | |
| Insulin/ELK-SRF/HIF1A/MYC/SREBF Expression Targets | |
| NOTCH Expression Targets | |
| Insulin/CEBPA/CTNNB/FOXA/FOXO Expression Targets | |
| non-small cell lung cancer pathway | |
| phosphatidylinositol 3-kinase-Akt signaling pathway | |
| phosphatidylinositol 3-kinase-Akt signaling pathway | |
| non-small cell lung cancer pathway |
| Group | AKT |
|---|---|
| Oncogenes | |
| cell proliferation | |
| regulation of G1-S transition checkpoint | |
| germ cell development | |
| positive regulation of cyclin-dependent protein kinase activity involved in G1-S | |
| negative regulation of JNK cascade | |
| negative regulation of release of cytochrome c from mitochondria | |
| signal transduction | |
| intracellular signal transduction | |
| protein kinase B signaling cascade | |
| phosphatidylinositol-mediated signaling | |
| G-protein coupled receptor signaling pathway | |
| nerve growth factor receptor signaling pathway | |
| fibroblast growth factor receptor signaling pathway | |
| insulin receptor signaling pathway | |
| insulin-like growth factor receptor signaling pathway | |
| epidermal growth factor receptor signaling pathway | |
| positive regulation of cell growth | |
| negative regulation of fatty acid beta-oxidation | |
| positive regulation of proteasomal ubiquitin-dependent protein catabolic process | |
| positive regulation of cellular protein metabolic process | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of glycogen biosynthetic process | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of protein phosphorylation | |
| positive regulation of peptidyl-serine phosphorylation | |
| positive regulation of glucose metabolic process | |
| negative regulation of protein kinase activity | |
| regulation of glycogen biosynthetic process | |
| regulation of translation | |
| positive regulation of sequence-specific DNA binding transcription factor activity | |
| negative regulation of plasma membrane long-chain fatty acid transport | |
| negative regulation of apoptotic process | |
| positive regulation of establishment of protein localization to plasma membrane | |
| T cell costimulation | |
| positive regulation of blood vessel endothelial cell migration | |
| positive regulation of fat cell differentiation | |
| positive regulation of apoptotic process | |
| regulation of neuron projection development | |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | |
| regulation of cell migration | |
| cell differentiation | |
| osteoblast differentiation | |
| mammary gland epithelial cell differentiation | |
| striated muscle cell differentiation | |
| glycogen cell differentiation involved in embryonic placenta development | |
| platelet activation | |
| RNA metabolic process | |
| mRNA metabolic process | |
| glycogen biosynthetic process | |
| glycogen metabolic process | |
| nitric oxide biosynthetic process | |
| cellular protein modification process | |
| translation | |
| protein phosphorylation | |
| peptidyl-serine phosphorylation | |
| protein autophosphorylation | |
| protein ubiquitination | |
| phosphorylation | |
| peripheral nervous system myelin maintenance | |
| cellular response to growth factor stimulus | |
| cellular response to insulin stimulus | |
| cellular response to epidermal growth factor stimulus | |
| cellular response to hypoxia | |
| apoptotic process | |
| activation-induced cell death of T cells | |
| cell projection organization | |
| cytoskeleton organization | |
| apoptotic mitochondrial changes | |
| response to food | |
| response to hormone stimulus | |
| response to fluid shear stress | |
| response to heat | |
| inflammatory response | |
| response to UV-A | |
| positive regulation of vasoconstriction | |
| positive regulation of lipid biosynthetic process | |
| positive regulation of sodium ion transport | |
| positive regulation of glucose import | |
| positive regulation of nitric-oxide synthase activity | |
| regulation of nitric-oxide synthase activity | |
| regulation of protein localization | |
| multicellular organismal development | |
| aging | |
| anagen | |
| endocrine pancreas development | |
| maternal placenta development | |
| nervous system development | |
| labyrinthine layer blood vessel development | |
| blood coagulation | |
| transport | |
| protein import into nucleus, translocation | |
| carbohydrate transport | |
| glucose transport | |
| carbohydrate metabolic process | |
| glucose metabolic process | |
| protein catabolic process | |
| small molecule metabolic process | |
| gene expression | |
| nitric oxide metabolic process | |
| negative regulation of cell size | |
| glucose homeostasis | |
| enzyme binding | |
| protein kinase binding | |
| protein kinase C binding | |
| nucleotide binding | |
| ATP binding | |
| phospholipid binding | |
| phosphatidylinositol-3,4,5-trisphosphate binding | |
| phosphatidylinositol-3,4-bisphosphate binding | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| nitric-oxide synthase regulator activity | |
| membrane | |
| nucleoplasm | |
| spindle | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| microtubule cytoskeleton | |
| nucleus | |
| lamellipodium | |
| Secreted proteins | |
| Biofluids assayable substances |
| Source | Curated |
|---|
| MedScan ID | 207 |
|---|
| Hugo ID | 391 |
|---|
| Human chromosome position | 14q32.32 |
|---|
| LocusLink ID | 207 |
|---|---|
| 11651 | |
| 24185 | |
| 50586 |
| Alias | AKT |
|---|---|
| PKB | |
| RAC | |
| PRKBA | |
| PKB-ALPHA | |
| RAC-ALPHA | |
| RAC-alpha serine/threonine-protein kinase | |
| PKB alpha | |
| RAC-PK-alpha | |
| proto-oncogene c-Akt | |
| protein kinase B alpha | |
| rac protein kinase alpha | |
| PKB/Akt | |
| PKBalpha | |
| AKT1 kinase | |
| protein kinase B-alpha | |
| related to A and C kinases | |
| thymoma viral proto-oncogene 1 | |
| RAC protein kinase alpha RAC-PK alpha | |
| murine thymoma viral (v-akt) oncogene homolog 1 | |
| v-akt murine thymoma viral oncogene homolog I | |
| thymoma viral proto-oncogene 1; thymoma viral proto-oncogene | |
| Protein kinase B | |
| RAC-alpha serine/threonine kinase | |
| serine/threonine protein kinase B | |
| thymoma viral proto-oncogene I | |
| v-akt murine thymoma viral oncogene homolog 1 | |
| thymoma viral proto-oncogene | |
| Akt I | |
| PKB/Akts | |
| OTTMUSP00000022949 | |
| 6.1a protein | |
| Akt/PKB | |
| Akt/PKBs | |
| Akt1 | |
| AKTI | |
| C6.1A | |
| Murine thymoma viral (v-akt) oncogene homolog I | |
| C-AKT | |
| OTTMUSP00000022947 | |
| OTTMUSP00000022944 | |
| MGC99656 | |
| MGC29148 | |
| LOC268604 | |
| LOC217879 | |
| murine thymoma viral (v-akt) oncogene homolog-1 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 164730 |
|---|---|
| 114480 | |
| 114500 | |
| 167000 | |
| 176920 | |
| 181500 | |
| 604370 |
| Unigene ID | Hs.525622 |
|---|---|
| Mm.6645 | |
| Rn.11422 |
| KEGG ID | hsa:207 |
|---|---|
| mmu:11651 | |
| rno:24185 |
| Swiss-Prot Accession | B0LPE5 |
|---|---|
| P31749 | |
| B3KVH4 | |
| P31750 | |
| P47196 | |
| B2RAM5 | |
| Q9BWB6 | |
| Q62274 | |
| Q6GSA6 | |
| Q9BV07 | |
| Q8BS26 | |
| Q6ZMW5 |
| EC Number | 2.7.11.1 |
|---|---|
| 2.7.1.37 |
| GO ID | 0005524 |
|---|---|
| 0019899 | |
| 0016301 | |
| 0030235 | |
| 0005547 | |
| 0043325 | |
| 0005080 | |
| 0004672 | |
| 0004674 | |
| 0007186 | |
| 0016070 | |
| 0031295 | |
| 0008633 | |
| 0006924 | |
| 0042640 | |
| 0008637 | |
| 0006915 | |
| 0007596 | |
| 0030154 | |
| 0030030 | |
| 0008283 | |
| 0006464 | |
| 0071364 | |
| 0032869 | |
| 0031018 | |
| 0007173 | |
| 0008543 | |
| 0010467 | |
| 0007281 | |
| 0042593 | |
| 0006006 | |
| 0015758 | |
| 0005978 | |
| 0060709 | |
| 0006954 | |
| 0008286 | |
| 0048009 | |
| 0035556 | |
| 0060716 | |
| 0016071 | |
| 0060644 | |
| 0001893 | |
| 0046329 | |
| 0043066 | |
| 0045792 | |
| 0043154 | |
| 0031999 | |
| 0010748 | |
| 0006469 | |
| 0090201 | |
| 0048011 | |
| 0006809 | |
| 0046209 | |
| 0001649 | |
| 0018105 | |
| 0032287 | |
| 0048015 | |
| 0016310 | |
| 0030168 | |
| 0043536 | |
| 0030307 | |
| 0032270 | |
| 0031659 | |
| 0090004 | |
| 0045600 | |
| 0046326 | |
| 0010907 | |
| 0045725 | |
| 0046889 | |
| 0045429 | |
| 0051000 | |
| 0033138 | |
| 0032436 | |
| 0001934 | |
| 0051091 | |
| 0010765 | |
| 0045944 | |
| 0046777 | |
| 0030163 | |
| 0000060 | |
| 0043491 | |
| 0006468 | |
| 0016567 | |
| 2001047 | |
| 0030334 | |
| 0005979 | |
| 0010975 | |
| 0050999 | |
| 0006417 | |
| 0070141 | |
| 0034405 | |
| 0032094 | |
| 0009408 | |
| 0007165 | |
| 0044281 | |
| 0051146 | |
| 0006412 | |
| 0005737 | |
| 0005829 | |
| 0030027 | |
| 0015630 | |
| 0005654 | |
| 0005634 | |
| 0005886 | |
| 0005819 | |
| 0000166 | |
| 0005543 | |
| 0019901 | |
| 0016740 | |
| 0016772 | |
| 0007568 | |
| 0005975 | |
| 0008643 | |
| 0071363 | |
| 0071456 | |
| 0007010 | |
| 0005977 | |
| 0007275 | |
| 0007399 | |
| 0043065 | |
| 0045907 | |
| 0032880 | |
| 0009725 | |
| 0006810 | |
| 0016020 | |
| 0006916 | |
| 0045768 | |
| 0045884 | |
| 0023034 | |
| 0001764 | |
| 0005625 | |
| 0005856 | |
| 0042802 | |
| 0005351 | |
| 0001568 | |
| 0007242 | |
| 0001890 | |
| 0040018 | |
| 0070201 | |
| 0005515 | |
| 0006445 | |
| 0004713 | |
| 0000074 | |
| 0050875 | |
| 0004702 |
| PIR ID | JC2437 |
|---|---|
| A39360 | |
| S33364 |
| Swiss-Prot ID | AKT1_RAT |
|---|---|
| AKT1_HUMAN | |
| AKT1_MOUSE | |
| B0LPE5_HUMAN | |
| B3KVH4_HUMAN | |
| Q6GSA6_MOUSE |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus | |
| Cell membrane |
| IPI ID | IPI00212844 |
|---|---|
| IPI00012866 | |
| IPI00323969 | |
| IPI00556735 |
| Mouse chromosome position | 12 57.0 cM |
|---|
| Rat chromosome position | 6q32 |
|---|
| Homologene ID | 3785 |
|---|
| MGI ID | 87986 |
|---|
| RGD ID | 2081 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|
| KEGG pathway | Insulin signaling pathway |
|---|---|
| B cell receptor signaling pathway | |
| Apoptosis | |
| Jak-STAT signaling pathway | |
| Focal adhesion | |
| Tight junction | |
| Toll-like receptor signaling pathway | |
| MAPK signaling pathway | |
| T cell receptor signaling pathway | |
| Adipocytokine signaling pathway |