| URN | urn:agi-llid:4233 |
|---|---|
| Total Entities | 0 |
| Connectivity | 2139 |
| Name | MET |
| Description | met proto-oncogene |
| Notes | hepatocyte growth factor receptor; functions as a heterodimeric tyrosine kinase [RGD] |
| GO Molecular Function | transmembrane receptor protein tyrosine kinase activity |
|---|---|
| hepatocyte growth factor-activated receptor activity | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein tyrosine kinase activity | |
| receptor activity | |
| protein complex binding | |
| phosphatidylinositol 3-kinase binding | |
| beta-catenin binding | |
| phospholipase binding | |
| protein phosphatase binding | |
| protein heterodimerization activity | |
| nucleotide binding | |
| ATP binding |
| GO Cellular Component | membrane |
|---|---|
| extracellular region | |
| integral component of membrane | |
| integral component of plasma membrane | |
| basal plasma membrane | |
| postsynaptic membrane | |
| postsynaptic density | |
| plasma membrane | |
| cytoplasm | |
| sperm flagellum | |
| neuron projection | |
| dendrite | |
| neuronal cell body | |
| extracellular space | |
| excitatory synapse |
| GO Biological Process | male gonad development |
|---|---|
| lactation | |
| cell proliferation | |
| activation of MAPK activity | |
| adult behavior | |
| multicellular organismal development | |
| branching morphogenesis of an epithelial tube | |
| regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling | |
| brain development | |
| pancreas development | |
| muscle organ development | |
| liver development | |
| placenta development | |
| skeletal muscle tissue development | |
| central nervous system neuron differentiation | |
| oligodendrocyte development | |
| positive regulation of dendrite morphogenesis | |
| positive regulation of neuron projection development | |
| neuron migration | |
| axon guidance | |
| myotube differentiation | |
| cell aging | |
| positive regulation of mitosis | |
| signal transduction | |
| cell surface receptor signaling pathway | |
| transmembrane receptor protein tyrosine kinase signaling pathway | |
| hepatocyte growth factor receptor signaling pathway | |
| regulation of synaptic transmission | |
| regulation of excitatory postsynaptic membrane potential | |
| cellular response to glucose stimulus | |
| sperm motility | |
| muscle cell migration | |
| negative regulation of hydrogen peroxide-mediated programmed cell death | |
| myoblast proliferation | |
| positive regulation of glucose transport | |
| response to drug | |
| response to acid | |
| response to peptide hormone | |
| cellular response to peptide hormone stimulus | |
| cellular response to inorganic substance | |
| cellular response to arsenic-containing substance | |
| cellular response to growth factor stimulus | |
| cellular response to interleukin-6 | |
| response to organic cyclic compound | |
| response to wounding | |
| positive regulation of DNA replication | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of peptidyl-threonine phosphorylation | |
| positive regulation of peptidyl-serine phosphorylation | |
| positive regulation of gene expression | |
| negative regulation of transcription from RNA polymerase II promoter | |
| negative regulation of peptidyl-threonine phosphorylation | |
| protein phosphorylation | |
| peptidyl-tyrosine phosphorylation | |
| protein autophosphorylation | |
| phosphorylation | |
| glucose homeostasis |
| Pathway | Adherens Junction Assembly (Cadherins) |
|---|---|
| Androgen Receptor to c-Met Signaling in Prostate Cancer | |
| Fatty Acid Synthase Signaling in Prostate Cancer | |
| Prostate Cancer Overview | |
| Metastatic Colorectal Cancer Overview | |
| Mechanism of Cetuximab Resistance in Colorectal Cancer | |
| Proteins Involved in Pathogenesis of Multiple Myeloma | |
| Multiple Myeloma Overview | |
| Proteins Involved in Pathogenesis of Diffuse Large-B-cell Lymphoma | |
| Clear Cell Ovarian Carcinoma | |
| Proteins Involved in Pathogenesis of Clear Cell Ovarian Carcinoma | |
| Proteins Involved in Pathogenesis of High-grade Serous Ovarian Carcinoma | |
| Proteins Overexpressed in Ovarian Cancer | |
| Ovarian Cancer Overview | |
| MITF as a Regulator of Melanoma Cell Development | |
| Dedifferentiation and Metastatic Progression of Melanoma | |
| Proteins Involved in Pathogenesis of Melanoma | |
| MicroRNAs in Melanoma | |
| Melanoma Overview | |
| Proteins Involved in Pathogenesis of Prostate Cancer | |
| Cancer Overview | |
| Primary Glioblastoma | |
| Secondary Glioblastoma | |
| Proteins Involved in Pathogenesis of Glioblastoma | |
| Mesenchymal Subtype of Glioblastoma | |
| Activation of Glioma Stem Cell Program | |
| Glioma Invasion Signaling | |
| Proteins Involved in Pathogenesis of Glioma | |
| Proteins Involved in Pathogenesis of Astrocytoma | |
| Proteins Involved in Pathogenesis of Medulloblastoma | |
| Proteins Involved in Pathogenesis of Cataract | |
| Growth Factor Signaling in Pancreatic Cancer | |
| Pancreatic Ductal Carcinoma | |
| Proteins Involved in Pathogenesis of Pancreatic Cancer | |
| Growth Factor Signaling in Hepatocellular Carcinoma | |
| Proteins Involved in Pathogenesis of Hepatocellular Carcinoma | |
| Hepatocellular Carcinoma Overview | |
| HGFR -> AP-1/CREB/MYC signaling | |
| HGFR -> FOXO3A signaling | |
| HGFR -> STAT signaling | |
| TGFB1-TGFBR2 Expression Targets | |
| WNT3A Expression Targets | |
| IL6 Expression Targets | |
| IFNG-IFNR Expression Targets | |
| HGF/FOXO3A Expression Targets | |
| S1P Expression Targets | |
| FGF2/AP-1/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| HGF/STAT Expression Targets | |
| FGF2/STAT Expression Targets | |
| TGFB1-TGFBR1 Expression Targets | |
| HGF/AP-1/CREB/ELK-SRF/MYC Expression Targets | |
| PDGF/AP-1/CREB/CREBBP/MYC Expression Targets | |
| PDGF/STAT Expression Targets | |
| TGFB1-ACVRL1 Expression Targets | |
| TGFB1-TGFBR1/AP-1 Expression Targets | |
| TLR4/AP-1 Expression Targets | |
| TNF/AP-1 Expression Targets | |
| IL1B Expression Targets | |
| non-small cell lung cancer pathway | |
| pancreatic cancer pathway | |
| scatter factor-hepatocyte growth factor signaling pathway |
| Group | GFR |
|---|---|
| Oncogenes | |
| male gonad development | |
| lactation | |
| cell proliferation | |
| activation of MAPK activity | |
| adult behavior | |
| multicellular organismal development | |
| branching morphogenesis of an epithelial tube | |
| regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling | |
| brain development | |
| pancreas development | |
| muscle organ development | |
| liver development | |
| placenta development | |
| skeletal muscle tissue development | |
| central nervous system neuron differentiation | |
| oligodendrocyte development | |
| positive regulation of dendrite morphogenesis | |
| positive regulation of neuron projection development | |
| neuron migration | |
| axon guidance | |
| myotube differentiation | |
| cell aging | |
| positive regulation of mitosis | |
| signal transduction | |
| cell surface receptor signaling pathway | |
| transmembrane receptor protein tyrosine kinase activity | |
| hepatocyte growth factor-activated receptor activity | |
| transmembrane receptor protein tyrosine kinase signaling pathway | |
| hepatocyte growth factor receptor signaling pathway | |
| regulation of synaptic transmission | |
| regulation of excitatory postsynaptic membrane potential | |
| cellular response to glucose stimulus | |
| sperm motility | |
| muscle cell migration | |
| negative regulation of hydrogen peroxide-mediated programmed cell death | |
| myoblast proliferation | |
| positive regulation of glucose transport | |
| response to drug | |
| response to acid | |
| response to peptide hormone | |
| cellular response to peptide hormone stimulus | |
| cellular response to inorganic substance | |
| cellular response to arsenic-containing substance | |
| cellular response to growth factor stimulus | |
| cellular response to interleukin-6 | |
| response to organic cyclic compound | |
| response to wounding | |
| positive regulation of DNA replication | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of peptidyl-threonine phosphorylation | |
| positive regulation of peptidyl-serine phosphorylation | |
| positive regulation of gene expression | |
| negative regulation of transcription from RNA polymerase II promoter | |
| negative regulation of peptidyl-threonine phosphorylation | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein tyrosine kinase activity | |
| protein phosphorylation | |
| peptidyl-tyrosine phosphorylation | |
| protein autophosphorylation | |
| phosphorylation | |
| glucose homeostasis | |
| receptor activity | |
| protein complex binding | |
| phosphatidylinositol 3-kinase binding | |
| beta-catenin binding | |
| phospholipase binding | |
| protein phosphatase binding | |
| protein heterodimerization activity | |
| nucleotide binding | |
| ATP binding | |
| membrane | |
| extracellular region | |
| integral component of membrane | |
| integral component of plasma membrane | |
| basal plasma membrane | |
| postsynaptic membrane | |
| postsynaptic density | |
| plasma membrane | |
| cytoplasm | |
| sperm flagellum | |
| neuron projection | |
| dendrite | |
| neuronal cell body | |
| extracellular space | |
| excitatory synapse | |
| Genes with Mutations Associated with Hepatocellular Carcinoma | |
| Genes with Mutations, Deletions, and Amplifications Associated with Glioma | |
| Secreted proteins | |
| Biofluids assayable substances |
| Source | Curated |
|---|
| LocusLink ID | 4233 |
|---|---|
| 17295 | |
| 24553 |
| Cell Localization | Plasma membrane |
|---|---|
| Membrane | |
| Secreted |
| GO ID | 0005524 |
|---|---|
| 0005008 | |
| 0019903 | |
| 0004713 | |
| 0000187 | |
| 0030534 | |
| 0007411 | |
| 0007420 | |
| 0048754 | |
| 0008283 | |
| 0007166 | |
| 0042593 | |
| 0001889 | |
| 0014812 | |
| 0051450 | |
| 0014902 | |
| 1901299 | |
| 0018108 | |
| 0001890 | |
| 0010828 | |
| 0045944 | |
| 0046777 | |
| 0060665 | |
| 0007165 | |
| 0007519 | |
| 0009925 | |
| 0005576 | |
| 0016021 | |
| 0005887 | |
| 0005886 | |
| 0008013 | |
| 0016301 | |
| 0000166 | |
| 0043548 | |
| 0043274 | |
| 0032403 | |
| 0046982 | |
| 0004672 | |
| 0004872 | |
| 0016740 | |
| 0016772 | |
| 0004714 | |
| 0048012 | |
| 0007275 | |
| 0007517 | |
| 0010801 | |
| 0000122 | |
| 0001764 | |
| 0016310 | |
| 0045740 | |
| 0050775 | |
| 0010628 | |
| 0045840 | |
| 0010976 | |
| 0033138 | |
| 0010800 | |
| 0006468 | |
| 0060079 | |
| 0050804 | |
| 0030317 | |
| 0007169 | |
| 0005737 | |
| 0030425 | |
| 0060076 | |
| 0005615 | |
| 0016020 | |
| 0043005 | |
| 0043025 | |
| 0014069 | |
| 0045211 | |
| 0036126 | |
| 0007569 | |
| 0071243 | |
| 0071333 | |
| 0071363 | |
| 0071241 | |
| 0071354 | |
| 0071375 | |
| 0021953 | |
| 0007595 | |
| 0008584 | |
| 0014003 | |
| 0031016 | |
| 0001101 | |
| 0042493 | |
| 0014070 | |
| 0043434 | |
| 0009611 | |
| 0019861 | |
| 0010553 | |
| 0010552 | |
| 0005624 | |
| 0030707 | |
| 0051789 | |
| 0005515 | |
| 0003779 | |
| 0004871 | |
| 0007223 | |
| 0030036 | |
| 0051016 | |
| 0008290 | |
| 0005794 | |
| 0000139 | |
| 0005578 | |
| 0004674 |
| Alias | HGFR |
|---|---|
| AUTS9 | |
| RCCP2 | |
| c-Met | |
| hepatocyte growth factor receptor | |
| SF receptor | |
| HGF receptor | |
| HGF/SF receptor | |
| proto-oncogene c-Met | |
| scatter factor receptor | |
| tyrosine-protein kinase Met | |
| met proto-oncogene tyrosine kinase | |
| HGF | |
| Par4 | |
| AI838057 | |
| met proto-oncogene (hepatocyte growth factor receptor) | |
| OTTMUSP00000028498 | |
| met proto-oncogene (hepatocyte growth factor receptor)s | |
| Met receptor | |
| Met receptors | |
| MET_HUMAN | |
| met proto-oncogene | |
| Oncogene MET | |
| OTTHUMP00000069168 | |
| OTTMUSP00000028499 | |
| receptor Met | |
| oncoprotein c Met | |
| proto-oncogene proteins c-met | |
| mesenchymal-epithelial transition factor | |
| met proto-onco | |
| HGF R | |
| Hepatocyte growth factor/scatter factor receptor | |
| c-Met receptor | |
| c-Met receptors | |
| HGF receptors | |
| Hepatocyte growth factor receptors | |
| Met proto- oncogene tyrosine kinase | |
| HGF/SF receptors | |
| LOC497783 | |
| MET | |
| Met protein | |
| LOC368085 | |
| LOC367980 | |
| LOC360378 | |
| LOC194383 | |
| HGF-SF receptor | |
| MET Oncogene | |
| protein Met | |
| pulmonary adenoma resistance 4 |
| Mouse chromosome position | 6 7.83 cM |
|---|---|
| 6 4.0 cM |
| OMIM ID | 164860 |
|---|---|
| 114550 | |
| 605074 | |
| 611015 |
| Rat chromosome position | 4q21 |
|---|
| Hugo ID | 7029 |
|---|
| Human chromosome position | 7q31 |
|---|
| Swiss-Prot Accession | P08581 |
|---|---|
| B4DLF5 | |
| A4FUV6 | |
| F8VQL0 | |
| P16056 | |
| P97523 | |
| A1L467 | |
| B5A932 | |
| E7EQ94 | |
| O60366 | |
| Q12875 | |
| Q9UDX7 | |
| Q9UPL8 | |
| P97579 | |
| Q63119 | |
| Q63964 | |
| Q14825 | |
| Q59EB3 | |
| Q9UEJ3 | |
| Q9UMU9 | |
| Q3TCS4 | |
| Q6Q531 | |
| Q6Q532 | |
| Q6Q533 | |
| O35515 | |
| Q2IBC7 | |
| Q99MC5 |
| PIR ID | A40175 |
|---|---|
| PC2131 |
| Unigene ID | Hs.132966 |
|---|---|
| Mm.86844 | |
| Rn.10617 |
| KEGG ID | hsa:4233 |
|---|---|
| mmu:17295 | |
| rno:24553 |
| Swiss-Prot ID | MET_HUMAN |
|---|---|
| MET_RAT | |
| A1L467_HUMAN | |
| A4FUV6_MOUSE |
| EC Number | 2.7.10.1 |
|---|
| Ensembl ID | ENSG00000105976 |
|---|---|
| ENSP00000380860 | |
| ENST00000397752 | |
| ENSMUSG00000009376 | |
| ENSMUSP00000111103 | |
| ENSMUST00000115443 | |
| ENSRNOG00000007079 | |
| ENSRNOP00000009662 | |
| ENSRNOT00000009662 |
| Homologene ID | 206 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 96969 |
|---|---|
| 1197520 |
| RGD ID | 3082 |
|---|
| MedScan ID | 4233 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|
| IPI ID | IPI00029273 |
|---|---|
| IPI00294528 | |
| IPI00326236 | |
| IPI00130420 | |
| IPI00884102 | |
| IPI00795476 | |
| IPI00852650 | |
| IPI00892811 | |
| IPI00853590 | |
| IPI00886414 | |
| IPI00858098 | |
| IPI00857365 | |
| IPI00857254 | |
| IPI00210405 | |
| IPI00734796 | |
| IPI00189518 |