| URN | urn:agi-llid:3845 |
|---|---|
| Total Entities | 0 |
| Connectivity | 2144 |
| Name | KRAS |
| Description | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog |
| Notes | oncogene and member of the small GTPase superfamily [RGD] |
| GO Molecular Function | GTPase activity |
|---|---|
| protein complex binding | |
| LRR domain binding | |
| nucleotide binding | |
| GDP binding | |
| GTP binding | |
| GMP binding |
| GO Cellular Component | membrane |
|---|---|
| membrane raft | |
| intracellular | |
| plasma membrane | |
| mitochondrion |
| GO Biological Process | leukocyte migration |
|---|---|
| innate immune response | |
| Fc-epsilon receptor signaling pathway | |
| MAPK cascade | |
| activation of MAPKK activity | |
| positive regulation of MAP kinase activity | |
| GTP catabolic process | |
| positive regulation of nitric-oxide synthase activity | |
| blood coagulation | |
| visual learning | |
| axon guidance | |
| striated muscle cell differentiation | |
| actin cytoskeleton organization | |
| signal transduction | |
| small GTPase mediated signal transduction | |
| Ras protein signal transduction | |
| positive regulation of Rac protein signal transduction | |
| cytokine-mediated signaling pathway | |
| neurotrophin TRK receptor signaling pathway | |
| insulin receptor signaling pathway | |
| fibroblast growth factor receptor signaling pathway | |
| epidermal growth factor receptor signaling pathway | |
| regulation of synaptic transmission, GABAergic | |
| regulation of long-term neuronal synaptic plasticity | |
| negative regulation of neuron apoptotic process | |
| positive regulation of cell proliferation | |
| response to glucocorticoid | |
| response to mineralocorticoid | |
| social behavior | |
| positive regulation of protein phosphorylation | |
| positive regulation of gene expression | |
| positive regulation of NF-kappaB transcription factor activity |
| Pathway | Mechanism of Cetuximab Resistance in Colorectal Cancer |
|---|---|
| FLT3 and KIT Signaling to MLL Pathway in Acute Myeloid Leukemia (M5) | |
| Block of Apoptosis in Acute Myeloid Leukemia | |
| Block of Differentiation in Acute Myeloid Leukemia | |
| Acute Myeloid Leukemia Overview | |
| Multiple Myeloma Overview | |
| Proteins Involved in Pathogenesis of Acute Myeloid Leukemia | |
| Proteins Involved in Pathogenesis of T-cell Acute Lymphoblastic Leukemia | |
| Dendritic Cells in Psoriasis | |
| Proliferative Diabetic Retinopathy | |
| Role of Advanced Glycation End Products Pathway in Diabetic Microangiopathy | |
| Peripheral Tissue Microangiopathy in Insulin Resistance | |
| Clear Cell Ovarian Carcinoma | |
| Mucinous Ovarian Carcinoma | |
| High-grade Serous Ovarian Carcinoma | |
| Proteins Involved in Pathogenesis of Mucinous Ovarian Carcinoma | |
| Endometrioid Ovarian Carcinoma | |
| Proteins Involved in Pathogenesis of Endometrioid Ovarian Carcinoma | |
| Ovarian Cancer Overview | |
| Low-grade Serous Ovarian Carcinoma | |
| Proteins Involved in Pathogenesis of Low-grade Serous Ovarian Carcinoma | |
| Type I Endometrial Cancer (Endometrioid Endometrial Cancer) | |
| Type II Endometrial Cancer (Clear-cell Endometrial Cancer and Papillary Serous Endometrial Cancer) | |
| Proteins Involved in Pathogenesis of Endometrial Cancer | |
| Endometrial Cancer Overview | |
| Proteins Involved in Pathogenesis of Melanoma | |
| RAGE/AGER and S100 Proteins in Cardiovascular Injury in Atherosclerosis | |
| Proteins Involved in Pathogenesis of Glioblastoma | |
| Proteins Involved in Pathogenesis of Glioma | |
| Osteoarthritis Overview | |
| Growth Factor Signaling in Pancreatic Cancer | |
| TGFBR Signaling in Pancreatic Cancer | |
| Pancreatic Ductal Carcinoma | |
| Proteins Involved in Pathogenesis of Pancreatic Cancer | |
| Pancreatic Neuroendocrine Tumors | |
| Growth Factor Signaling in Hepatocellular Carcinoma | |
| Proteins Involved in Pathogenesis of Hepatocellular Carcinoma | |
| Hepatocellular Carcinoma Overview | |
| Myocardial Remodeling in Myocardial Ischemia | |
| Myocardial Infarction | |
| CHRNA7 -> NOS1 production | |
| AGER -> NF-kB signaling | |
| AGER -> CREB/SP1 signaling | |
| CholinergicRn -> CREB signaling | |
| S100A Expression Targets | |
| S100B Expression Targets | |
| S100P Expression Target | |
| HMGB1 Expression Targets | |
| TTR Expression Targets | |
| Acetylcholine Expression Targets | |
| non-small cell lung cancer pathway | |
| colorectal cancer pathway | |
| pancreatic cancer pathway | |
| endometrial cancer pathway | |
| the extracellular signal-regulated Raf/Mek/Erk signaling pathway | |
| the extracellular signal-regulated Raf-Mek-Erk signaling pathway | |
| colorectal cancer pathway |
| Group | Ras |
|---|---|
| Oncogenes | |
| leukocyte migration | |
| innate immune response | |
| Fc-epsilon receptor signaling pathway | |
| MAPK cascade | |
| activation of MAPKK activity | |
| positive regulation of MAP kinase activity | |
| GTP catabolic process | |
| GTPase activity | |
| positive regulation of nitric-oxide synthase activity | |
| blood coagulation | |
| visual learning | |
| axon guidance | |
| striated muscle cell differentiation | |
| actin cytoskeleton organization | |
| signal transduction | |
| small GTPase mediated signal transduction | |
| Ras protein signal transduction | |
| positive regulation of Rac protein signal transduction | |
| cytokine-mediated signaling pathway | |
| neurotrophin TRK receptor signaling pathway | |
| insulin receptor signaling pathway | |
| fibroblast growth factor receptor signaling pathway | |
| epidermal growth factor receptor signaling pathway | |
| regulation of synaptic transmission, GABAergic | |
| regulation of long-term neuronal synaptic plasticity | |
| negative regulation of neuron apoptotic process | |
| positive regulation of cell proliferation | |
| response to glucocorticoid | |
| response to mineralocorticoid | |
| social behavior | |
| positive regulation of protein phosphorylation | |
| positive regulation of gene expression | |
| positive regulation of NF-kappaB transcription factor activity | |
| protein complex binding | |
| LRR domain binding | |
| nucleotide binding | |
| GDP binding | |
| GTP binding | |
| GMP binding | |
| membrane | |
| membrane raft | |
| intracellular | |
| plasma membrane | |
| mitochondrion | |
| Genes with Mutations Associated with Acute Myeloid Leukemia | |
| Genes with Mutations Associated with Multiple Myeloma | |
| Genes with Mutations Associated with Breast Cancer | |
| Genes with Mutations Associated with Ovarian Cancer | |
| Genes with Mutations Associated with Endometrial Cancer | |
| Proteins Involved in Pathogenesis of Cowden Syndrome | |
| Genes with Mutations Associated with Hepatocellular Carcinoma | |
| Disease Genes Identified in Syndromic Epilepsy | |
| Genes with Mutations Associated with Pancreatic Cancer | |
| Secreted proteins | |
| Biofluids assayable substances |
| Source | Curated |
|---|---|
| GO component | |
| ResNet |
| LocusLink ID | 3845 |
|---|---|
| 16653 | |
| 24525 | |
| 101200 | |
| 232521 | |
| 550286 |
| Cell Localization | Cytoplasm |
|---|---|
| Cell membrane | |
| Plasma membrane |
| GO ID | 0019003 |
|---|---|
| 0019002 | |
| 0005525 | |
| 0003924 | |
| 0030275 | |
| 0038095 | |
| 0000165 | |
| 0007265 | |
| 0030036 | |
| 0000186 | |
| 0007411 | |
| 0007596 | |
| 0019221 | |
| 0007173 | |
| 0008543 | |
| 0045087 | |
| 0008286 | |
| 0050900 | |
| 0043524 | |
| 0048011 | |
| 0043406 | |
| 0051092 | |
| 0035022 | |
| 0008284 | |
| 0010628 | |
| 0051000 | |
| 0001934 | |
| 0048169 | |
| 0032228 | |
| 0051384 | |
| 0051385 | |
| 0007264 | |
| 0035176 | |
| 0051146 | |
| 0008542 | |
| 0045121 | |
| 0005739 | |
| 0005886 | |
| 0000166 | |
| 0032403 | |
| 0006184 | |
| 0007165 | |
| 0005622 | |
| 0016020 | |
| 0007569 | |
| 0006897 | |
| 0005624 | |
| 0005515 | |
| 0007605 | |
| 0051726 | |
| 0000074 | |
| 0006886 | |
| 0005524 | |
| 0005579 | |
| 0003930 | |
| 0003925 | |
| 0008151 |
| Alias | NS |
|---|---|
| NS3 | |
| CFC2 | |
| KRAS1 | |
| KRAS2 | |
| RASK2 | |
| KI-RAS | |
| C-K-RAS | |
| K-RAS2A | |
| K-RAS2B | |
| K-RAS4A | |
| K-RAS4B | |
| GTPase KRas | |
| K-Ras 2 | |
| c-Ki-ras | |
| oncogene KRAS2 | |
| K-ras p21 protein | |
| c-Kirsten-ras protein | |
| PR310 c-K-ras oncogene | |
| transforming protein p21 | |
| cellular c-Ki-ras2 proto-oncogene | |
| v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | |
| v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog | |
| ras | |
| p21B | |
| K-ras | |
| Kras-2 | |
| AI929937 | |
| RP24-359O2.1 | |
| p21 protein | |
| Kirsten rat sarcoma oncogene 2, expressed | |
| p21 | |
| c-K-ras2 protein | |
| c-Kirsten-ras proto-oncogene | |
| Kirsten rat sarcoma viral oncogene homologue 2 (active) | |
| Kirsten rat sarcoma viral oncogene | |
| K-RASA | |
| K-RasB | |
| MGC7141 | |
| OTTMUSP00000025006 | |
| OTTMUSP00000025007 | |
| Transforming protein p21b | |
| Kirsten rat sarcoma viral oncogene homolog | |
| K-ras p21 | |
| c-K-ras proteins | |
| c-K-ras2 | |
| c-K-ras2 protein isoform a | |
| c-K-ras2 protein isoform b | |
| KRAS | |
| K-Ras 2B | |
| Kirsten rat sarcoma-2 viral (v-Ki-ras2) oncogene homolog | |
| expressed sequence AI929937 | |
| c-K-ras protein | |
| P21-B | |
| P(21)B | |
| P-21B | |
| P 21B | |
| NS 3 | |
| NS(3) | |
| LOC550286 | |
| chromosome | |
| scaffold | |
| zgc:110250 |
| Mouse chromosome position | 6 77.37 cM |
|---|---|
| 6 71.2 cM |
| OMIM ID | 190070 |
|---|---|
| 260350 | |
| 615278 | |
| 163200 | |
| 114480 | |
| 137215 | |
| 211980 | |
| 109800 | |
| 609942 | |
| 115150 | |
| 218040 | |
| OMIM:190070 |
| Rat chromosome position | 4q44 |
|---|
| Hugo ID | 6407 |
|---|
| Human chromosome position | 12p12.1 |
|---|
| Swiss-Prot Accession | P01116 |
|---|---|
| L7RSL8 | |
| P32883 | |
| Q5J7N1 | |
| A0JN17 | |
| P08644 | |
| P46203 | |
| P97914 | |
| A8K8Z5 | |
| B0LPF9 | |
| P01118 | |
| Q96D10 | |
| P04200 | |
| P08643 | |
| Q14014 | |
| Q14015 | |
| Q15285 | |
| Q71SP6 | |
| Q7KZ06 | |
| Q92668 | |
| Q0VDV7 | |
| Q3U2W7 | |
| Q53WZ3 | |
| Q9QWR5 | |
| Q96FS0 |
| PIR ID | I58402 |
|---|---|
| A93311 | |
| B93311 | |
| A01365 | |
| B01365 |
| Unigene ID | Hs.505033 |
|---|---|
| Mm.383182 | |
| Rn.24554 | |
| Mm.46847 | |
| Dr.85525 | |
| Mm.207540 | |
| Hs.447488 | |
| Mm.31530 | |
| Hs.433714 |
| KEGG ID | hsa:3845 |
|---|---|
| mmu:16653 | |
| rno:24525 |
| Swiss-Prot ID | RASK_RAT |
|---|---|
| RASK_HUMAN | |
| RASK_MOUSE | |
| Q5J7N1_MOUSE | |
| A0JN17_RAT | |
| A8K8Z5_HUMAN | |
| B0LPF9_HUMAN | |
| Q3U2W7_MOUSE |
| Ensembl ID | ENSG00000133703 |
|---|---|
| ENSP00000308495 | |
| ENST00000311936 | |
| ENSMUSG00000030265 | |
| ENSMUSP00000032399 | |
| ENSMUST00000032399 |
| Homologene ID | 37990 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Danio rerio | |
| Human |
| MGI ID | 96680 |
|---|---|
| 2141518 |
| RGD ID | 2981 |
|---|
| MedScan ID | 3845 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00113248 |
|---|---|
| IPI00134941 | |
| IPI00203826 | |
| IPI00210097 | |
| IPI00423568 | |
| IPI00423570 | |
| IPI00790968 | |
| IPI00791238 | |
| IPI00845559 | |
| IPI00830951 | |
| IPI00857121 |
| KEGG pathway | Gap junction |
|---|---|
| Axon guidance | |
| Tight junction | |
| MAPK signaling pathway | |
| T cell receptor signaling pathway | |
| Insulin signaling pathway | |
| B cell receptor signaling pathway | |
| Natural killer cell mediated cytotoxicity | |
| Focal adhesion | |
| Dorso-ventral axis formation | |
| Regulation of actin cytoskeleton | |
| Chronic myeloid leukemia | |
| Colorectal cancer | |
| Fc epsilon RI signaling pathway | |
| Glioma | |
| GnRH signaling pathway | |
| Long-term depression | |
| Long-term potentiation | |
| Melanoma | |
| Pancreatic cancer | |
| Thyroid cancer | |
| VEGF signaling pathway | |
| Endometrial cancer | |
| ErbB signaling pathway | |
| Melanogenesis | |
| Non-small cell lung cancer | |
| Prostate cancer | |
| Renal cell carcinoma |
| Homo sapiens Chromosome position | 12p12.1 |
|---|
| Microarray ID | 97991_at |
|---|---|
| 231640_at | |
| 225469_at | |
| 32159_at | |
| M54968_at | |
| 1940_at | |
| 204010_s_at | |
| A_23_P45140 | |
| I_1221964 | |
| 1370035_at | |
| rc_AA944575_at | |
| U09793_at | |
| rc_AI045340_at | |
| 1426228_at | |
| 1426229_s_at | |
| 1451979_at | |
| 140481_r_at | |
| x02452_s_at | |
| Msa.1988.0_at | |
| A_51_P377237 | |
| X00485 | |
| A_65_P20250 | |
| H3048A01-3 | |
| 204009_s_at | |
| 214352_s_at | |
| A_51_P240768 | |
| A_51_P136233 | |
| 1559203_s_at | |
| 1559204_x_at | |
| A_14_P109860 | |
| A_14_P100435 | |
| A_14_P106292 | |
| A_23_P306500 | |
| A_23_P306507 | |
| A_24_P927287 |
| FunctionalClass | GTP binding |
|---|---|
| GTPase | |
| nucleotide binding | |
| protein binding | |
| GDP binding | |
| GMP binding | |
| LRR domain binding | |
| ATP binding |
| Mus musculus Chromosome position | 6 71.2 cM |
|---|---|
| 6 |
| Rattus norvegicus Chromosome position | 4q44 |
|---|
| Keyword | oncogene |
|---|---|
| plasma membrane | |
| RAS small monomeric GTPase | |
| antisense RNA | |
| microtubule |
| State Description | Transcript Variant: This variant (b) is composed of five exons and lacks exon 4a which the longer transcript variant (a) includes. This predominant variant (b) has a cds that terminates in exon 4b, encoding a unique C terminus. |
|---|---|
| Transcript Variant: This variant (a) is composed of six exons, including exon 4a, which the shorter transcript variant b lacks. This rare variant (a) has a cds that terminates in exon 4a, encoding a unique C terminus. |
| State | c-K-ras2 protein isoform b |
|---|---|
| c-K-ras2 protein isoform a |