Protein MAP2K1

URN urn:agi-llid:5604
Total Entities 0
Connectivity 1607
Name MAP2K1
Description mitogen activated protein kinase kinase 1
Notes kinase that activates Mapk3 (Erk1) and Mapk1 (Erk2) kinases [RGD]

GO Molecular Function receptor signaling protein tyrosine phosphatase activity
MAP kinase kinase activity
protein serine-threonine kinase activator activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
protein kinase activity
protein tyrosine kinase activity
protein serine-threonine-tyrosine kinase activity
protein serine-threonine kinase activity
protein kinase binding
mitogen-activated protein kinase kinase kinase binding
Ras GTPase binding
nucleotide binding
ATP binding

GO Cellular Component microtubule
spindle pole body
plasma membrane
cytoplasm
Golgi apparatus
cell cortex
cytosol
perinuclear region of cytoplasm
mitochondrion
late endosome
early endosome
dendrite cytoplasm
cytoskeleton
nucleus
axon
dendrite
perikaryon
focal adhesion

GO Biological Process toll-like receptor signaling pathway
toll-like receptor 4 signaling pathway
toll-like receptor 10 signaling pathway
toll-like receptor 2 signaling pathway
toll-like receptor TLR1:TLR2 signaling pathway
toll-like receptor 5 signaling pathway
toll-like receptor TLR6:TLR2 signaling pathway
MyD88-dependent toll-like receptor signaling pathway
toll-like receptor 3 signaling pathway
MyD88-independent toll-like receptor signaling pathway
toll-like receptor 9 signaling pathway
TRIF-dependent toll-like receptor signaling pathway
innate immune response
Fc-epsilon receptor signaling pathway
cell proliferation
MAPK cascade
stress-activated MAPK cascade
regulation of stress-activated MAPK cascade
activation of MAPKK activity
activation of MAPK activity
positive regulation of Ras GTPase activity
regulation of vascular smooth muscle contraction
placenta blood vessel development
labyrinthine layer development
keratinocyte differentiation
neuron differentiation
axon guidance
neuron projection morphogenesis
positive regulation of cell differentiation
cellular senescence
cellular component movement
mitosis
cell cycle arrest
vesicle transport along microtubule
signal transduction
intracellular signal transduction
small GTPase mediated signal transduction
Ras protein signal transduction
positive regulation of Ras protein signal transduction
neurotrophin TRK receptor signaling pathway
insulin receptor signaling pathway
fibroblast growth factor receptor signaling pathway
epidermal growth factor receptor signaling pathway
negative regulation of homotypic cell-cell adhesion
cell motility
positive regulation of cell migration
melanosome transport
negative regulation of cell proliferation
regulation of early endosome to late endosome transport
chemotaxis
response to glucocorticoid
response to oxidative stress
response to axon injury
positive regulation of transcription elongation from RNA polymerase II promoter
positive regulation of protein serine-threonine kinase activity
regulation of Golgi inheritance
protein phosphorylation
peptidyl-tyrosine dephosphorylation
phosphorylation
Golgi inheritance
protein heterooligomerization

Pathway Alzheimer's Disease Overview
IL-6/IGF-1/VEGFA in Multiple Myeloma
Osteoclast Activation in Multiple Myeloma
Cowden Syndrome
Interleukin-22 Induced Keratinocyte Proliferation in Psoriasis
Interleukin-17 Signaling in Psoriatic Keratinocytes
Proteins Involved in Pathogenesis of Breast Cancer Related to ERBB2/VEGFR/Akt Signaling Pathway
Proteins Involved in Pathogenesis of Breast Cancer Related to IGF1R/Akt Signaling Pathway
Breast Cancer Related to IGF1R/Akt Signaling Pathway
Breast Cancer Related to ERBB/VEGFR/Akt Signaling Pathway
Breast Cancer Related to ESR1 Signaling Pathway
Proteins Involved in Pathogenesis of Breast Cancer Related to ESR1 Signaling Pathway
ESR1/ERBB-positive Luminal Breast Cancer
Basal Breast Cancer
Proliferative Diabetic Retinopathy
Insulin Influence on Glycogenesis
Role of Protein Kinase C in Diabetic Microangiopathy
CD8+ T-cell Response to Self-Determinants in Diabetes Mellitus Type 1
Impaired Peripheral Tolerance to Autoantigens in Diabetes Mellitus Type 1
Insulin Influence on Protein Synthesis
Impaired Adiponectin Synthesis in Insulin Resistance
Role of Advanced Glycation End Products Pathway in Diabetic Microangiopathy
Peripheral Tissue Microangiopathy in Insulin Resistance
Congenital Hypothyroidism Due to Thyroid-Stimulating Hormone Resistance
Graves Ophthalmopathy
Thyroid Dysfunction in Graves Disease
Cardiovascular Effects of Hyperthyroidism
Common Non-genomic Effects of Thyroid Hormones
Primary Overt Hypothyroidism Overview
Overt Hypothyroidism Influence on Thyroid-Stimulating Hormone Secretion
Clear Cell Ovarian Carcinoma
Mucinous Ovarian Carcinoma
High-grade Serous Ovarian Carcinoma
Endometrioid Ovarian Carcinoma
Ovarian Cancer Overview
Low-grade Serous Ovarian Carcinoma
Type I Endometrial Cancer (Endometrioid Endometrial Cancer)
Type II Endometrial Cancer (Clear-cell Endometrial Cancer and Papillary Serous Endometrial Cancer)
Endometrial Cancer Overview
Deregulation of Cell Cycle in Melanoma
Block of Apoptosis in Melanoma
MITF as a Regulator of Melanoma Cell Development
Melanoma Overview
Th1 Cell Function in Systemic Lupus Erythematosus
Th2 Cell Function in Systemic Lupus Erythematosus
B-cell Activation in Systemic Lupus Erythematosus
Th0 Cell Aberrant Activation in Systemic Lupus Erythematosus
T-cell-Dependent B-cell Activation
T-cell-Independent B-cell Activation
Natural Killer Cell Activation through C-type Lectin-like Receptors
Natural Killer Cell Activation through ITSM-Containing Receptors
Natural Killer Cell Activation through ITAM-Containing Receptors
Natural Killer Cell Inhibitory Receptor Signaling
Natural Killer Cell Activation through Integrins and non-ITAM-Containing Receptors
Model of T-cell Maturation
CD8+ T-cell Activation
Natural Killer Cell Activation
Th1 Cell Differentiation
T-cell Receptor Signaling
Regulatory T-cell Differentiation
Th2 Cell Differentiation
Cancer Overview
Contraction due Vasospasm
Mucin Production in Goblet Airway Epithelial Cells in Cystic Fibrosis
Activation and Proliferation of Th1 Cells in Atherosclerosis
RAGE/AGER and S100 Proteins in Cardiovascular Injury in Atherosclerosis
Onset of Atopic Dermatitis
Mast Cells in Atopic Dermatitis
Mechanisms of Cardiomyocyte Hypertrophy in Hypertrophic Cardiomyopathy
Hypertrophic Cardiomyopathy Overview
Smooth Muscle Cell Dysfunction in Pulmonary Arterial Hypertension
Primary Glioblastoma
Secondary Glioblastoma
Astrocytoma
CCR5 Signaling in Macrophages in HIV Type 1 Infection
Impairment of CD8+ T-cell Action in HIV Type 1 Infection
Block of CD4+ T-cell Signaling in HIV Type 1 Infection
CD4+ T-cell Death in HIV Type 1 Infection
TNF and IL1B Induce Metalloproteinase Synthesis
IL1B-Induced Arthralgia in Osteoarthritis
Osteoarthritis Overview
Steroid-Induced Cataract
Proteins Involved in Pathogenesis of Cataract
Impairment of EDN, NRG, NRTN, and GDNF/RET Signaling in Hirschsprung Disease
Growth Factor Signaling in Neuroblastoma
ALK-Associated Neuroblastoma
Neuroblastoma Overview
Growth Factor Signaling in Pancreatic Cancer
TGFBR Signaling in Pancreatic Cancer
Pancreatic Ductal Carcinoma
Pancreatic Neuroendocrine Tumors
FSH Action in Polycystic Ovary Syndrome
Impaired Steroidogenesis in Polycystic Ovary Syndrome
Block of Ovulation in Polycystic Ovary Syndrome
Polycystic Ovary Syndrome Overview
Growth Factor Signaling in Hepatocellular Carcinoma
Hepatocellular Carcinoma Overview
Osteoclast Activation in Gout
Synovial Fibroblast Proliferation in Rheumatoid Arthritis
Osteoclast Activation in Rheumatoid Arthritis
PTPN22 Involvement in Rheumatoid Arthritis
Induction of Apoptosis and Immediate Early Gene Activation in Hippocampal Neurons Following Seizures
Effects of BDNF Upregulation Induced by Seizures
Mechanism of Skin Fibrosis in Systemic Scleroderma
B-cells Function in Systemic Scleroderma
Role of Th2 cells in Systemic Scleroderma
Myocardial Remodeling in Myocardial Ischemia
WHIM Syndrom Overview
Role of Scavenger Receptor OLR1 in Inflammation-Related Endothelial Dysfunction in Atherosclerosis
ADRA1 -> vasoconstriction
ADRA2C/ADRB2 -> vasoconstriction
ADRA1 -> prostaglandin generation
ADRA1A -> IL6 production
ADRB1 -> prostaglandin generation
ADRA2C/ADRB2 -> synaptic endocytosis
GABA(B)R -> postsynaptic inhibition
NMDA receptors -> Ca2+/CREB activation/PGE2 synthesis
P2RY11/13/14 -> IL8/10 production
BDKRB1/2 -> prostaglandin generation
HRH2/4 -> IL6/10 production
PTGER1/4 -> vascular motility
PTGER2/3 -> inflammation-related expression targets
PTGIR -> IL6 production
HTR5 -> TNF production
HTR1 -> IL6 production
HTR7 -> IL6 production
CNR1/2 -> IL1B/2/4/6/10 production
Nociception-related DRD2 expression targets
Nociception-related DRD1/5 expression targets
EDNRA/B -> vascular motility
CHRM1/2/3 -> vascular motility
CHRM1 -> IL2 production
CHRNA7 -> NOS1 production
NPY1R -> CRH/POMC production
Nociception-related NTSR1 expression targets
GALR1/2/3 -> POMC/NPY production
Nociception-related IL1B expression targets
Nociception-related IL6 expression targets
Summarized nociception-related expression targets
Summarized vascular motility pathway
OPRK -> pain perception
FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling
PDGFR -> AP-1/MYC signaling
VEGFR -> AP-1/CREB/MYC signaling
HGFR -> AP-1/CREB/MYC signaling
AngiopoietinR -> AP-1 signaling
ErythropoietinR -> AP-1/CREB/MYC signaling
ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling
EGFR -> AP-1/CREB/ELK-SRF/MYC signaling
EGFR -> NCOR2 signaling
EctodysplasinR -> AP-1 signaling
TNFRSF6 -> HSF1 signaling
NGFR -> AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling
TNFR -> CREB/ELK-SRF signaling
TNFR -> AP-1/ATF/TP53 signaling
TNFRSF1A -> AP-1/ATF/TP53 signaling
TNFRSF1A -> CREB/ELK-SRF signaling
Notch -> TCF3 signaling
PTPRC -> BCL6 signaling
T-cell receptor -> AP-1 signaling
FcIgER -> ELK-SRF signaling
IL1R -> NF-kB signaling
AGER -> CREB/SP1 signaling
EGFR/ERBB2 -> HIF1A signaling
EGFR -> AP-1/ATF2 signaling
EGFR/ERBB2 -> TP53 signaling
ERBB2/3 -> EP300/ETS/ETV/SP1 signaling
EGFR -> SMAD1 signaling
FGFR -> RUNX2 signaling
KIT -> MITF signaling
VEGFR -> ATF/CREB/ELK-SRF signaling
IGF1R -> ELK-SRF/HIF1A/MYC/SREBF signaling
InsulinR -> ELK-SRF/SREBF signaling
GDNF -> HSF1 signaling
NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling
UrokinaseR -> ELK-SRF signaling
NCAM1 -> CREB/ELK-SRF/MYC signaling
ICAM1 -> AP-1/CREB/ELK-SRF signaling
PECAM -> SP1 signaling
FibronectinR -> AP-1/ELK-SRF/SREBF signaling
SELE -> ELK-SRF signaling
B-cell receptor -> AP-1 signaling
CD19 -> AP-1/ELK-SRF signaling
IL4R -> ELK-SRF/HMGY signaling
IL6R -> CEBP/ELK-SRF signaling
IL2R -> ELK-SRF/MYC signaling
ErythropoietinR -> ELK-SRF/FOS signaling
LeptinR -> ELK-SRF signaling
ThrombopoietinR -> SP1 signaling
GHR -> ELK-SRF/MYC signaling
EDG2 -> ELK-SRF signaling
CholinergicRm -> CREB/ELK-SRF signaling
CannabinoidR -> AP-1/EGR signaling
NeuropeptideYR -> ATF/CREB signaling
DopamineR2 -> AP-1/CREB/ELK-SRF signaling
SerotoninR1 -> FOS signaling
PTAFR -> AP-1/ATF1/CREB/ERK-SRF signaling
CholecystokininR -> ELK-SRF signaling
SerotoninR2 -> ELK-SRF/GATA4 signaling
OxytocinR -> ELK-SRF/GATA/AP-1 signaling
NeurotensinR -> ELK-SRF/AP-1/EGR signaling
AdrenergicRa -> ELK-SRF signaling
AdenosineR -> AP-1 signaling
VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling
ProstaglandinFR -> ATF1/ELK-SRF/CREB signaling
OpioidR -> CREB/ELK-SRF/STAT3 signaling
GNRHR -> ELK-SRF signaling
GRM1/5 -> CREB signaling
AdrenergicRa -> STAT3 signaling
IL8R -> CREB/EGR signaling
EDG3/5 -> AP-1/ELK-SRF signaling
EndothelinRb -> AP-1/CREB/ELK-SRF signaling
ProstaglandinIR -> ATF1/ELK-SRF/CREB signaling
AdrenergicRb -> CREB signaling
TachykininR -> ELK-SRF signaling
VIPR -> CREB/CEBP signaling
EndothelinRa -> AP-1/CREB signaling
AdrenergicRb -> STAT3 signaling
AngiotensinR -> CREB/ELK-SRF/TP53 signaling
DopamineR1 -> CREB/ELK-SRF signaling
SerotoninR4/6/7 -> NR3C signaling
FSHR -> CREB/ELK-SRF/GATA4 signaling
VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling
GlucagonR -> CREB/ELK-SRF/SP1 signaling
ThromboxaneR -> CREB signaling
ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling
CD38 -> NF-kB signaling
CholinergicRn -> CREB signaling
Clozapine-Induced Granulocytopenia
ROS in Angiotensin-Mediated Cardiovascular Remodeling and Hypertrophy
FASLG Expression Targets
NGF/FOXO/MYCN/ELK-SRF Expression Targets
BDNF Expression Targets
NTF3 Expression Targets
NTF4 Expression Targets
CD40LG/NF-kB/ELK-SRF/CREB/NFATC Expression Targets
TNFSF13 Expression Targets
TNFSF13B Expression Targets
EDA Expression Targets
TNFSF10 Expression Targets
LTA Expression Targets
TNFSF14 Expression Targets
TNF/CREB Expression Targets
TNF/TP53/ATF Expression Targets
TNF/ELK-SRF Expression Targets
NGF/AP-1/TP53/MYC Expression Targets
NGF/CREB/CEBPB/MEF2A Expression Targets
CD40LG/ATF2/AP-1/TP53/E2F Expression Targets
ICAM1 Expression Targets
Fibronectin Expression Targets
NCAM1 Expression Targets
CD21 Expression Targets
Gamma Globulins Expression Targets
CD247 Expression Targets
FCGR3A Expression Targets
PECAM1 Expression Targets
PLAU/ELK-SRF/AP-1 Expression Targets
CD19 Expression Targets
CD81 Expression Targets
IL6 Expression Targets
IL2 Expression Targets
IL4 Expression Targets
Thrombopoietin/SP1 Expression Targets
Erythropoietin/ELK-SRF Expression Targets
GH1-GHR/NF-kB/ELK-SRF/MYC Expression Targets
PRL-GHR/NF-kB/ELK-SRF/MYC Expression Targets
CSH1-GHR Expression Targets
Leptin/ELK-SRF Expression Targets
NPY Expression Targets
Dopamine/Gi Expression Targets
Dronabinol/Anandamide Expression Targets
GNRH2 Expression Targets
S100A Expression Targets
S100B Expression Targets
S100P Expression Target
HMGB1 Expression Targets
TTR Expression Targets
Acetylcholine Expression Targets
PTPRC/BCL6 Expression Targets
AREG/SMAD1 Expression Target
AREG/AP-1 Expression Targets
AREG/HIF1A Expression Targets
BTC/EP300/ETS/ETV/SP1 Expression Targets
EGF/HIF1A Expression Targets
EGF/TP53 Expression Targets
EREG/AP-1/ATF Expression Targets
EREG/EP300/SP1 Expression Targets
EREG/HIF1A Expression Target
HBEGF/AP-1/ATF Expression Targets
HBEGF/EP300/ETS/ETV/SP1 Expression Targets
HBEGF/HIF1A Expression Targets
HBEGF/TP53 Expression Targets
NRG1/AP-1/ATF Expression Targets
NRG1/EP300/ETS/ETV/SP1 Expression Targets
NRG1/HIF1A Expression Target
NRG1/TP53 Expression Target
TGFA/HIF1A Expression Targets
TGFA/TP53 Expression Targets
FGF2/RUNX Expression Targets
FGF7/RUNX Expression Targets
FGF8/RUNX Expression Targets
FGF9/RUNX Expression Targets
VEGFA/ATF/CREB/ELK-SRF Expression Targets
VEGFC/ATF Expression Target
GDNF/HSF1 Expression Targets
IGF2/HIF1A/MYC Expression Targets
CTGF/AP-1/CREB/MYC Expression Targets
CTGF/NCOR2 Expression Target
Erythropoietin/AP-1/MYC/CREB Expression Targets
FLT3LG/AP-1/CREB/CREBBP Expression Targets
GAS6/AP-1/CREB Expression Targets
PGF/AP-1/CREB/CREBBP/MYC Expression Targets
Thrombopoietin/AP-1/CREB/CREBBP/MYC Expression Targets
AREG/CREB/CREBBP Expression Targets
AREG/NCOR2 Expression Targets
EGF/NCOR2 Expression Target
EREG/CREB Expression Target
HBEGF/CREB/MYC Expression Targets
NRG1/CREB/CREBBP/ELK-SRF/MYC Expression Targets
TGFA/CREB/CREBBP/ELK-SRF/MYC Expression Targets
FGF1/AP-1/CREB/ELK-SRF/MYC Expression Targets
FGF1/NCOR2 Expression Target
FGF2/NCOR2 Expression Targets
FGF4/AP-1/MYC Expression Targets
FGF7/AP-1/CREB/CREBBP/MYC Expression Targets
FGF8/AP-1/CREB/MYC Expression Targets
FGF9/AP-1/CREB/MYC Expression Targets
FGF10/AP-1/CREB/CREBBP/MYC Expression Targets
FGF18/AP-1/CREB Expression Targets
FGF23/NCOR2 Expression Targets
CSF1/AP-1/CREB/CREBBP/MYC Expression Targets
PDGFB/AP-1/CREB/MYC Expression Target
PDGFC/CREB Expression Target
PDGFD/AP-1 Expression Targets
VEGFA/NCOR2 Expression Target
ANGPT1/CREB/CREBBP Expression Targets
ANGPT2/AP-1/CREBBP/MYC Expression Targets
FIGF/AP-1 Expression Target
FIGF/NCOR2 Expression Target
F2 -> AP-1/CREB/ELK-SRF/SP1 Expression Targets
Thromboxane A2 Expression Targets
PLG -> AP-1/CREB/ELK-SRF/SP1 Expression Targets
OXT Expression Targets
Serotonin/Gq Expression Targets
Epinephrine/Gq Expression Targets
Adenosine Expression Targets
Prostaglandin F Expression Targets
Glutamate/Gq Expression Targets
CCK Expression Targets
AVP/Gq -> CREB/ELK-SRF/AP-1/EGR Expression Targets
GNRH1 Expression Targets
Morphine Expression Targets
NTS Expression Targets
GAST Expression Targets
S1P Expression Targets
TAC1 Expression Targets
PGE1 Expression Targets
Epinephrine/Gs Expression Targets
Noradrenaline/Gs Expression Targets
VIP Expression Targets
Dopamine/Gs Expression Targets
GCG Expression Targets
FSHR Expression Targets
AVP/Gs -> CREB/ELK-SRF/AP-1/EGR Expression Targets
Serotonin/Gs Expression Targets
Noreadrenaline/Gq Expression Targets
POMC Expression Targets
IFNA1/Gq Expression Targets
CXCL1 Expression Targets
CXCL2 Expression Targets
CXCL3 Expression Targets
CXCL5 Expression Targets
CXCL6 Expression Targets
EDN1 Expression Targets
EDN3 Expression Targets
ADCYAP1 Expression Targets
IL16/AP-1 Expression Targets
CD8/AP-1 Expression Targets
CD80/AP-1 Expression Targets
CD86/AP-1 Expression Targets
CD72/AP-1 Expression Targets
PDCD1/AP-1 Expression Targets
TCR/AP-1 Expression Targets
AGT/TP53 Expression Targets
AGT/ELK-SRF Expression Targets
FGF2/AP-1/CREB/CREBBP/ELK-SRF/MYC Expression Targets
Insulin/ELK-SRF/HIF1A/MYC/SREBF Expression Targets
IL1A Expression Targets
IL1B/PGE2 Expression Targets
NOTCH Expression Targets
AGT/CREB Expression Targets
EGF/AP-1/ATF Expression Targets
EGF/CREB/CREBBP/ELK-SRF/MYC Expression Targets
HGF/AP-1/CREB/ELK-SRF/MYC Expression Targets
IGF1/ELK-SRF/HIF1A/MYC/SREBF Expression Targets
IL1B/NO Expression Targets
KITLG/AP-1/CREB/CREBBP/MYC Expression Targets
LPA Expression Targets
PAF/Gq -> AP-1/ATF1/CREB/ERK-SRF Expression Targets
PDGF/AP-1/CREB/CREBBP/MYC Expression Targets
TGFA/AP-1/ATF Expression Targets
TNF/AP-1 Expression Targets
VEGFA/AP-1/CREBBP/MYC Expression Targets
IL1B Expression Targets
BTC/AP-1/ATF/CREB Expression Targets
FGF1/RUNX Expression Targets
non-small cell lung cancer pathway
the extracellular signal-regulated Raf/Mek/Erk signaling pathway
the extracellular signal-regulated Raf-Mek-Erk signaling pathway

Group MEK1/2
toll-like receptor signaling pathway
toll-like receptor 4 signaling pathway
toll-like receptor 10 signaling pathway
toll-like receptor 2 signaling pathway
toll-like receptor TLR1:TLR2 signaling pathway
toll-like receptor 5 signaling pathway
toll-like receptor TLR6:TLR2 signaling pathway
MyD88-dependent toll-like receptor signaling pathway
toll-like receptor 3 signaling pathway
MyD88-independent toll-like receptor signaling pathway
toll-like receptor 9 signaling pathway
TRIF-dependent toll-like receptor signaling pathway
innate immune response
Fc-epsilon receptor signaling pathway
cell proliferation
receptor signaling protein tyrosine phosphatase activity
MAPK cascade
stress-activated MAPK cascade
MAP kinase kinase activity
regulation of stress-activated MAPK cascade
activation of MAPKK activity
activation of MAPK activity
positive regulation of Ras GTPase activity
regulation of vascular smooth muscle contraction
placenta blood vessel development
labyrinthine layer development
keratinocyte differentiation
neuron differentiation
axon guidance
neuron projection morphogenesis
positive regulation of cell differentiation
cellular senescence
cellular component movement
mitosis
cell cycle arrest
vesicle transport along microtubule
signal transduction
intracellular signal transduction
small GTPase mediated signal transduction
Ras protein signal transduction
positive regulation of Ras protein signal transduction
neurotrophin TRK receptor signaling pathway
insulin receptor signaling pathway
fibroblast growth factor receptor signaling pathway
epidermal growth factor receptor signaling pathway
negative regulation of homotypic cell-cell adhesion
cell motility
positive regulation of cell migration
melanosome transport
negative regulation of cell proliferation
regulation of early endosome to late endosome transport
chemotaxis
response to glucocorticoid
response to oxidative stress
response to axon injury
positive regulation of transcription elongation from RNA polymerase II promoter
positive regulation of protein serine-threonine kinase activity
protein serine-threonine kinase activator activity
regulation of Golgi inheritance
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
protein kinase activity
protein tyrosine kinase activity
protein serine-threonine-tyrosine kinase activity
protein serine-threonine kinase activity
protein phosphorylation
peptidyl-tyrosine dephosphorylation
phosphorylation
Golgi inheritance
protein heterooligomerization
protein kinase binding
mitogen-activated protein kinase kinase kinase binding
Ras GTPase binding
nucleotide binding
ATP binding
microtubule
spindle pole body
plasma membrane
cytoplasm
Golgi apparatus
cell cortex
cytosol
perinuclear region of cytoplasm
mitochondrion
late endosome
early endosome
dendrite cytoplasm
cytoskeleton
nucleus
axon
dendrite
perikaryon
focal adhesion
Proteins Involved in Pathogenesis of Cowden Syndrome
Disease Genes Identified in Syndromic Epilepsy
Secreted proteins
Biofluids assayable substances

Source Curated
GO component

LocusLink ID 5604
26395
170851
19101
326395
533199
406728
336209
336276

Cell Localization Cytoplasm
Cytoskeleton
Microtubule organizing center
Centrosome
Spindle pole body
Nucleus

GO ID 0005524
0004708
0017016
0031435
0004672
0043539
0004674
0004712
0004713
0004728
0038095
0048313
0000165
0002755
0002756
0007265
0035666
0000187
0000186
0007411
0007050
0048870
0008283
0006928
0090398
0006935
0007173
0008543
0045087
0008286
0030216
0060711
0032402
0007067
0008285
0034111
0048011
0060674
0032320
0046579
0045597
0030335
0071902
0032968
0051291
0090170
2000641
0032872
0003056
0048678
0051384
0006979
0007165
0007264
0051403
0034166
0034134
0034138
0034142
0034146
0034162
0038123
0038124
0002224
0047496
0005794
0005938
0005737
0005829
0032839
0005769
0005925
0005770
0005739
0005634
0043204
0048471
0005886
0005816
0016301
0000166
0019901
0016740
0016772
0030182
0048812
0035335
0016310
0006468
0030424
0005856
0030425
0005874
0035556
0008063
0034130
0033267
0007243
0010149
0005625
0005515
0043406
0005575

Alias CFC3
MEK1
MKK1
MAPKK1
PRKMK1
dual specificity mitogen-activated protein kinase kinase 1
MEK 1
MAPKK 1
MAPK/ERK kinase 1
ERK activator kinase 1
protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)
MEKK1
MAP kinase kinase 1
mitogen activated protein kinase kinase 1
protein kinase, mitogen activated, kinase 1, p45
MAP kinase/Erk kinase 1
mitogen-activated protein kinase kinase 1
MPK I
mitogen-activated protein kinase kinase I
MKK I
MPK1
MPK1_HUMAN
OTTMUSP00000018355
PRKMK I
MAPK/ERK kinase I
MAPKK I
ERK kinase I
MEK I
Dual specificity mitogen-activated protein kinase kinase I
ERK kinase 1
MAP kinase kinase 1 , splice form A
MAPK kinase 1
ERK activator kinase I
MAPK kinase I
MAP kinase kinase I
MAP2K1
Map2k I
MAP kinase/Erk kinase I
PRKMK1s
MAPKK1s
protein kinase, mitogen-activated, kinase I
protein kinase, mitogen-activated, kinase 1
PRKMK Is
MAPKK Is
Edpm9
Map3k1
Estrogen-dependent pituitary mass QTL 9
MAPKKK1
oestrogen-dependent pituitary mass qtl, chromosome 9
Estrogen-dependent pituitary mass QTL, Chromosome 9
Estrogen-dependent pituitary mass QTL IX
kinase, mitogen activated, kinase 1, p
Mekk
oestrogen-dependent pituitary mass qtl, chromosome IX
kinase 1
kinase 1 (MAP kinase kinase 1)
mitogen-activated
protein kinase
fj61b01
si:ch211-242m18.2
wu:fj61b01
CH73-94F11.4
MGC113988
chromosome
scaffold
wu:fj56a12
zgc:56557

Mouse chromosome position 9 34.55 cM
9 36.0 cM

OMIM ID 176872
615279
115150
61385
OMIM:176872

Rat chromosome position 8q24

Hugo ID 6840

Human chromosome position 15q22.1-q22.33

Swiss-Prot Accession A4QPA9
Q02750
B4DFY5
P31938
Q3TMJ8
Q01986
Q5EBD5
Q3TMW4
Q3U3F4
Q3UK05
Q9JJE1
MP2K1_HUMAN

PIR ID I59571
A45100
JN0840

GenBank ID NC_000015
XM_005254541
XP_005254598
NM_002755
NP_002746
XM_005254540
XP_005254597
NG_008305
NC_018926
AC_000147
ABBA01038819
ABBA01038820
ABBA01038821
ABBA01038822
AC011276
AC055855
AC116913
AMYH02030645
AMYH02030646
AMYH02030647
AMYH02030648
AMYH02030649
CH471082
EAW77765
EAW77766
EAW77767
EAW77768
EAW77769
AK291500
BAF84189
AK294322
BAG57596
AK312356
BC137459
AAI37460
BC139729
AAI39730
BE856741
BG709050
CA419665
DA653983
L05624
AAA36318
L11284
Q02750
NC_000075
XM_006511197
XP_006511260
XM_006511196
XP_006511259
NM_008927
NP_032953
AC_000031
AAHY01078835
AAHY01078836
AAHY01078837
AAHY01078838
AAHY01078839
AAHY01078840
AC160118
AY902345
AAY21055
CH466522
EDL26058
AB041567
BAA95051
AK146233
BAE26999
AK146931
BAE27542
AK154793
BAE32832
AK165664
BAE38326
AK165894
BAE38443
AK167336
BAE39437
AK192193
AK192210
AK193946
AK194551
AK196845
AK197193
AK199082
AK199200
AK199288
AK203853
AK214848
BC051137
BC054754
AAH54754
L02526
AAA39523
P31938
NC_005107
NM_031643
NP_113831
AC_000076
AABR06055284
AABR06055285
AAHX01055170
AAHX01055171
AAHX01055172
AAHX01055173
CH473975
EDL95791
AI603089
BC089772
AAH89772
D13341
BAA02603
D14591
BAA03441
X62313
CAA44192
Z16415
CAA78905
Q01986
NT_010194
NW_001838218
NW_925884
AC_000058
CR604502
CR621481
NT_039474
NW_001030907
Q3TMJ8
Q3TMW4
Q3U3F4
Q3UK05
Q9JJE1
NW_047799
NW_001084873
Q80XD2
AAH51137
59808149
59808148
407861
407860
220811
266566
220812
199124
199123
37540936
307183
346266
7670398
7670399
303803
24475715
AU041108
56628
56629
400275
6678793
6678794
400274
NT_086827
14589898
32451982
32451983
51472784
286228
Q5EBD5
51765023
29835265
29835266
NW_000353
5579478
188568
188569
33859656
13928886
34865068
119598171
123790130
123790854
123791419
123796627
62910170
74139093
74147303
74191215
74191750
74226698
74227056
81871107
81917507
81909568
111308433
122143526
AAI19887
BC119886
NC_007308
NW_001492790
Q0VD16
XM_612526
XP_612526
AW282020
123888458
148726469
30353821
66910416
82188372
82226062
94733356
AAH52120
AAH97064
AW281434
AW281751
BC052120
BC097064
BX927065
CAK04706
CAN88104
CT863714
NC_007113
NM_213419
NP_998584
NW_001512924
Q1LUY7
Q4V947
Q7ZTX6
119598172
119598173
119598174
119598175
141796928
148694111
149041950
76253797
126007177
76253798
ZDB-GENE-030131-8153
ZDB-GENE-030131-8220
406728
BC052120,BC097064
Dr.107100
Dr.81130
ZDB-GENE-040426-2759
dre:406728

Unigene ID Hs.145442
Mm.248907
Rn.5850
Mm.426740
Hs.132311
Mm.435672
Bt.29185
Dr.107100
Dr.81130
Mm.456154
Mm.465469

KEGG ID hsa:5604
mmu:26395
rno:170851

Swiss-Prot ID MP2K1_MOUSE
MP2K1_HUMAN
MP2K1_RAT
A4QPA9_HUMAN
Q3TMJ8_MOUSE

EC Number 2.7.12.2
2.7.1.-

Ensembl ID ENSMUSG00000004936
ENSMUSP00000005066
ENSMUST00000005066

Homologene ID 2063

Organism Homo sapiens
Mus musculus
Rattus norvegicus
Bos taurus
Danio rerio
Human

MGI ID 1346866
102562

RGD ID 70495

MedLine Reference 10570282
10912793
15299019
8388392
11841548
15145949
12477932
12876277
1379797
14963006
15469737
15737734
15917294
70317
8380494
8406028
8462694
9779826
10395327
10489373
10509564
10523642
10716983
10748187
10757792
10780709
10799874
10806207
10828601
10848576
10982368
10997882
11044099
11044439
11134045
11226259
11260070
11266467
11278389
11352917
11409852
11535599
11579140
11604401
11684694
11741894
11823456
11891225
11948406
12032872
12063167
12167619
12370306
12456688
12482669
12522135
12522145
12531514
12556561
12594221
12609978
12612059
12663662
12682854
12689928
12697810
12792650
12807433
1281467
12839928
12917419
12975377
14581471
14656894
14672918
15020233
15021912
15069060
15284233
15292274
15297310
15302887
15353548
15538402
15543157
15557124
15572374
15615716
15657353
15657590
15665520
15757891
15888452
15979847
16086581
16239230
16313339
16439621
16737746
16861903
16913865
17038630
17054908
7601337
7624324
7731720
7957875
7969158
8157000
8226933
8394352
8529659
8621729
8626767
8939914
9223324
9325171
9351825
9465908
9553107
9558095
9621077
9733512
9841871
10209122
10349636
10725249
10838075
10917603
11042159
11076861
11101507
11217851
11222509
11823472
12244094
12270934
12466851
12532330
12612072
12663500
12788225
12832465
12875843
1411546
14563325
14594209
14627958
14871928
15004527
15159407
15240686
15304090
15305288
15509711
15546878
15647843
15701678
15782199
15890671
16141072
16141073
16148006
16162927
16199873
16424016
16463380
16686604
16761309
16887817
16931773
7914033
8168826
8297798
8385802
8602221
8602223
8632902
9149902
9155017
9208850
9440696
9806642
9852579
10536014
11822869
11872750
12401521
12695496
16481589
17202850
11104681
16728640
16820947
16957420
17101779
17182854
17192257
17197157
17260965
17366577
17419998
17461449
8131746
9563949
1381507
15118098
15489334
17396120
15753041
15782137
17183546
17498664
17490600
17603482

MedScan ID 5604

Primary Cell Localization Cytoplasm

IPI ID IPI00219604
IPI00797850
IPI00231247
IPI00466610

Homo sapiens Chromosome position 15q22.1-q22.33

Microarray ID 92585_at
1367760_at
d14591_s_at
l04485mrna_s_at
rc_ai178835_at
A_42_P638191
1416351_at
99707_at
l02526_s_at
A_51_P241074
L05624
202670_at
60945_at
1130_at
1844_s_at
L05624_s_at
L11284_at
214592_s_at
A_32_P406652
A_32_P189110
A_23_P20248
A_14_P100756
A_14_P118260
A_14_P128795

FunctionalClass ATP binding
MAP kinase kinase
nucleotide binding
protein binding
protein serine/threonine kinase
protein-tyrosine kinase
transferase
kinase
protein kinase

Bos taurus Chromosome position 10

Mus musculus Chromosome position 9 36.0 cM

Rattus norvegicus Chromosome position 8q24

Hugo Symbol MAP2K1