| URN | urn:agi-llid:5290 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1014 |
| Name | Pik3ca |
| Description | phosphatidylinositol 3-kinase, catalytic, alpha polypeptide |
| Notes | expression of the human homolog is associated with increased cell proliferation and decreased apoptosis and may play a role in ovarian cancer progression [RGD] |
| GO Molecular Function | 1-phosphatidylinositol-3-kinase activity |
|---|---|
| phosphatidylinositol 3-kinase activity | |
| 1-phosphatidylinositol-4-phosphate 3-kinase activity | |
| phosphatidylinositol-4,5-bisphosphate 3-kinase activity | |
| protein kinase activator activity | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| phosphotransferase activity, alcohol group as acceptor | |
| protein serine-threonine kinase activity | |
| insulin receptor substrate binding | |
| nucleotide binding | |
| ATP binding |
| GO Cellular Component | phosphatidylinositol 3-kinase complex |
|---|---|
| 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex | |
| intracellular | |
| plasma membrane | |
| cytosol | |
| lamellipodium |
| GO Biological Process | leukocyte migration |
|---|---|
| Fc-gamma receptor signaling pathway involved in phagocytosis | |
| T cell receptor signaling pathway | |
| innate immune response | |
| Fc-epsilon receptor signaling pathway | |
| T cell costimulation | |
| small molecule metabolic process | |
| phosphatidylinositol biosynthetic process | |
| phosphatidylinositol-3-phosphate biosynthetic process | |
| glucose metabolic process | |
| phospholipid metabolic process | |
| phosphatidylinositol phosphorylation | |
| blood coagulation | |
| platelet activation | |
| cardiac muscle contraction | |
| vasculature development | |
| angiogenesis | |
| endothelial cell migration | |
| regulation of multicellular organism growth | |
| protein kinase B signaling | |
| phosphatidylinositol-mediated signaling | |
| neurotrophin TRK receptor signaling pathway | |
| insulin receptor signaling pathway | |
| fibroblast growth factor receptor signaling pathway | |
| insulin receptor signaling pathway via phosphatidylinositol 3-kinase | |
| epidermal growth factor receptor signaling pathway | |
| negative regulation of fibroblast apoptotic process | |
| negative regulation of neuron apoptotic process | |
| negative regulation of anoikis | |
| positive regulation of protein kinase activity | |
| positive regulation of peptidyl-serine phosphorylation | |
| regulation of genetic imprinting | |
| hypomethylation of CpG island | |
| protein phosphorylation | |
| phosphorylation |
| Pathway | Mechanism of Cetuximab Resistance in Colorectal Cancer |
|---|---|
| Cowden Syndrome | |
| Mantle Cell Lymphoma Overview | |
| PI3K/AKT/MTOR, NF-kB and BCR Signaling Deregulation in Mantle Cell Lymphoma | |
| Hedgehog Signaling in Mantle Cell Lymphoma | |
| Proteins Involved in Pathogenesis of Breast Cancer Related to ERBB2/VEGFR/Akt Signaling Pathway | |
| Proteins Involved in Pathogenesis of Breast Cancer Related to IGF1R/Akt Signaling Pathway | |
| Breast Cancer Related to IGF1R/Akt Signaling Pathway | |
| Breast Cancer Related to ERBB/VEGFR/Akt Signaling Pathway | |
| Breast Cancer Related to ESR1 Signaling Pathway | |
| Proteins Involved in Pathogenesis of Breast Cancer Related to ESR1 Signaling Pathway | |
| ESR1/ERBB-positive Luminal Breast Cancer | |
| Basal Breast Cancer | |
| Congenital Hypothyroidism Due to Thyroid-Stimulating Hormone Resistance | |
| Thyroid Dysfunction in Graves Disease | |
| Common Non-genomic Effects of Thyroid Hormones | |
| Primary Overt Hypothyroidism Overview | |
| Clear Cell Ovarian Carcinoma | |
| Proteins Involved in Pathogenesis of Clear Cell Ovarian Carcinoma | |
| Mucinous Ovarian Carcinoma | |
| High-grade Serous Ovarian Carcinoma | |
| Proteins Involved in Pathogenesis of Mucinous Ovarian Carcinoma | |
| Proteins Involved in Pathogenesis of High-grade Serous Ovarian Carcinoma | |
| Endometrioid Ovarian Carcinoma | |
| Proteins Involved in Pathogenesis of Endometrioid Ovarian Carcinoma | |
| Ovarian Cancer Overview | |
| Low-grade Serous Ovarian Carcinoma | |
| Proteins Involved in Pathogenesis of Low-grade Serous Ovarian Carcinoma | |
| Type I Endometrial Cancer (Endometrioid Endometrial Cancer) | |
| Type II Endometrial Cancer (Clear-cell Endometrial Cancer and Papillary Serous Endometrial Cancer) | |
| Proteins Involved in Pathogenesis of Endometrial Cancer | |
| Endometrial Cancer Overview | |
| Primary Glioblastoma | |
| Proneural Subtype of Glioblastoma | |
| Growth Factor Signaling in Pancreatic Cancer | |
| Pancreatic Ductal Carcinoma | |
| Pancreatic Neuroendocrine Tumors | |
| Growth Factor Signaling in Hepatocellular Carcinoma | |
| Hepatocellular Carcinoma Overview | |
| Myocardial Remodeling in Myocardial Ischemia | |
| Preconditioning Ischemia | |
| Myocardial Infarction | |
| non-small cell lung cancer pathway | |
| prostate cancer pathway | |
| endometrial cancer pathway | |
| phosphatidylinositol 3-kinase-Akt signaling pathway | |
| phosphatidylinositol 3-kinase-Akt signaling pathway | |
| phosphatidylinositol 3-kinase-Akt signaling pathway |
| Group | PI3K |
|---|---|
| leukocyte migration | |
| Fc-gamma receptor signaling pathway involved in phagocytosis | |
| T cell receptor signaling pathway | |
| innate immune response | |
| Fc-epsilon receptor signaling pathway | |
| T cell costimulation | |
| small molecule metabolic process | |
| phosphatidylinositol biosynthetic process | |
| phosphatidylinositol-3-phosphate biosynthetic process | |
| 1-phosphatidylinositol-3-kinase activity | |
| glucose metabolic process | |
| phospholipid metabolic process | |
| phosphatidylinositol phosphorylation | |
| phosphatidylinositol 3-kinase activity | |
| 1-phosphatidylinositol-4-phosphate 3-kinase activity | |
| phosphatidylinositol-4,5-bisphosphate 3-kinase activity | |
| blood coagulation | |
| platelet activation | |
| cardiac muscle contraction | |
| vasculature development | |
| angiogenesis | |
| endothelial cell migration | |
| regulation of multicellular organism growth | |
| protein kinase B signaling | |
| phosphatidylinositol-mediated signaling | |
| neurotrophin TRK receptor signaling pathway | |
| insulin receptor signaling pathway | |
| fibroblast growth factor receptor signaling pathway | |
| insulin receptor signaling pathway via phosphatidylinositol 3-kinase | |
| epidermal growth factor receptor signaling pathway | |
| negative regulation of fibroblast apoptotic process | |
| negative regulation of neuron apoptotic process | |
| negative regulation of anoikis | |
| positive regulation of protein kinase activity | |
| positive regulation of peptidyl-serine phosphorylation | |
| protein kinase activator activity | |
| regulation of genetic imprinting | |
| hypomethylation of CpG island | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| phosphotransferase activity, alcohol group as acceptor | |
| protein serine-threonine kinase activity | |
| protein phosphorylation | |
| phosphorylation | |
| insulin receptor substrate binding | |
| nucleotide binding | |
| ATP binding | |
| phosphatidylinositol 3-kinase complex | |
| 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex | |
| intracellular | |
| plasma membrane | |
| cytosol | |
| lamellipodium | |
| Genes with Mutations Associated with Cowden Syndrome | |
| Genes with Mutations Associated with Mantle Cell Lymphoma | |
| Genes with Mutations Associated with Endometrial Cancer | |
| Genes with Mutations Associated with Hepatocellular Carcinoma | |
| Genes with Mutations, Deletions, and Amplifications Associated with Primary Glioblastoma | |
| Genes with Mutations, Deletions, and Amplifications Associated with Glioma | |
| Biofluids assayable substances |
| LocusLink ID | 5290 |
|---|---|
| 18706 | |
| 170911 |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0016303 |
|---|---|
| 0035005 | |
| 0005524 | |
| 0043560 | |
| 0016301 | |
| 0035004 | |
| 0046934 | |
| 0030295 | |
| 0004674 | |
| 0038095 | |
| 0038096 | |
| 0031295 | |
| 0050852 | |
| 0001525 | |
| 0007596 | |
| 0060048 | |
| 0043542 | |
| 0007173 | |
| 0008543 | |
| 0006006 | |
| 0044029 | |
| 0045087 | |
| 0008286 | |
| 0038028 | |
| 0050900 | |
| 2000811 | |
| 0048011 | |
| 0006661 | |
| 0046854 | |
| 0048015 | |
| 0006644 | |
| 0030168 | |
| 0033138 | |
| 0043491 | |
| 2000653 | |
| 0040014 | |
| 0044281 | |
| 0001944 | |
| 0005943 | |
| 0005829 | |
| 0030027 | |
| 0005942 | |
| 0005886 | |
| 0000166 | |
| 0016773 | |
| 0016740 | |
| 0016772 | |
| 2000270 | |
| 0043524 | |
| 0036092 | |
| 0016310 | |
| 0045860 | |
| 0006468 | |
| 0005622 | |
| 0043066 | |
| 0006916 | |
| 0004428 | |
| 0007165 | |
| 0005488 | |
| 0005737 | |
| 0005739 | |
| 0005515 |
| Alias | MCM |
|---|---|
| CWS5 | |
| MCAP | |
| PI3K | |
| CLOVE | |
| MCMTC | |
| p110-alpha | |
| phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | |
| PI3K-alpha | |
| PI3-kinase p110 subunit alpha | |
| ptdIns-3-kinase subunit p110-alpha | |
| serine/threonine protein kinase PIK3CA | |
| phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha | |
| phosphoinositide-3-kinase, catalytic, alpha polypeptide | |
| phosphatidylinositol 3-kinase, catalytic, alpha polypeptide | |
| phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha | |
| phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform | |
| p110 | |
| caPI3K | |
| p110alpha | |
| 6330412C24Rik | |
| PI3Kalpha | |
| PI3-kinase subunit alpha | |
| ptdIns-3-kinase subunit alpha | |
| phosphoinositide-3-kinase catalytic alpha polypeptide | |
| phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha | |
| phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | |
| PtdIns-3-kinase p110 | |
| PIK3CA | |
| PI3K P110-ALPHA | |
| MGC116320 | |
| RIKEN cDNA 6330412C24 gene | |
| MGC161268 | |
| hydroxykinase | |
| hydroxykinases | |
| MGC142161 | |
| MGC142163 | |
| OTTMUSP00000023404 | |
| 6330412C24 | |
| Phosphatidylinositol 3-kinase catalytic subunit, alpha isoform | |
| OTTMUSP00000023403 |
| Mouse chromosome position | 3 15.7 cM |
|---|---|
| 3 12.4 cM |
| OMIM ID | 171834 |
|---|---|
| 612918 | |
| 615108 | |
| 162900 | |
| 114480 | |
| 114500 | |
| 114550 | |
| 182000 | |
| 211980 | |
| 602501 | |
| 603387 | |
| 167000 | |
| 613659 | |
| 137215 |
| Rat chromosome position | 2q25 |
|---|
| Hugo ID | 8975 |
|---|
| Human chromosome position | 3q26.3 |
|---|
| Swiss-Prot Accession | P42336 |
|---|---|
| P42337 | |
| Q0VGQ5 | |
| Q14CW1 | |
| Q99762 | |
| Q91XL6 |
| PIR ID | I38110 |
|---|
| Unigene ID | Hs.553498 |
|---|---|
| Hs.715194 | |
| Mm.260521 | |
| Rn.44193 | |
| Rn.190480 | |
| Rn.165275 |
| KEGG ID | hsa:5290 |
|---|---|
| mmu:18706 | |
| rno:170911 |
| Swiss-Prot ID | PK3CA_MOUSE |
|---|---|
| PK3CA_HUMAN |
| EC Number | 2.7.1.153 |
|---|---|
| 2.7.11.1 | |
| 2.7.1.137 |
| Ensembl ID | ENSMUSG00000027665 |
|---|---|
| ENSMUSP00000029201 | |
| ENSMUST00000029201 | |
| ENSMUSP00000103878 | |
| ENSMUST00000108243 | |
| ENSRNOG00000010458 | |
| ENSRNOP00000014527 | |
| ENSRNOT00000014527 |
| Homologene ID | 21249 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1206581 |
|---|
| RGD ID | 620916 |
|---|
| MedScan ID | 5290 |
|---|---|
| 170911 |
| Primary Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00309224 |
|---|---|
| IPI00031386 | |
| IPI00781719 | |
| IPI00779888 | |
| IPI00211380 | |
| IPI00769166 | |
| IPI00769069 | |
| IPI00766767 |