| URN | urn:agi-llid:207 |
|---|---|
| Total Entities | 0 |
| Connectivity | 9076 |
| Name | Akt1 |
| Description | thymoma viral proto-oncogene 1 |
| Notes | inhibits JUN kinase activation and mediates inhibition of apoptosis [RGD] |
| GO Molecular Function | nitric-oxide synthase regulator activity |
|---|---|
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| 14-3-3 protein binding | |
| enzyme binding | |
| protein kinase binding | |
| protein kinase C binding | |
| nucleotide binding | |
| ATP binding | |
| phosphatidylinositol-3,4,5-trisphosphate binding | |
| phosphatidylinositol-3,4-bisphosphate binding |
| GO Cellular Component | membrane |
|---|---|
| nucleoplasm | |
| spindle | |
| intracellular | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| mitochondrion | |
| microtubule cytoskeleton | |
| nucleus | |
| lamellipodium |
| GO Biological Process | germ cell development |
|---|---|
| maternal placenta development | |
| activation-induced cell death of T cells | |
| innate immune response | |
| Fc-epsilon receptor signaling pathway | |
| T cell costimulation | |
| cell proliferation | |
| small molecule metabolic process | |
| glycogen biosynthetic process | |
| positive regulation of glycogen biosynthetic process | |
| regulation of glycogen biosynthetic process | |
| positive regulation of lipid biosynthetic process | |
| negative regulation of JNK cascade | |
| negative regulation of fatty acid beta-oxidation | |
| glycogen metabolic process | |
| glucose metabolic process | |
| positive regulation of glucose metabolic process | |
| positive regulation of nitric-oxide synthase activity | |
| regulation of nitric-oxide synthase activity | |
| multicellular organismal development | |
| osteoblast differentiation | |
| positive regulation of vasoconstriction | |
| blood coagulation | |
| platelet activation | |
| peripheral nervous system myelin maintenance | |
| nervous system development | |
| labyrinthine layer blood vessel development | |
| glycogen cell differentiation involved in embryonic placenta development | |
| mammary gland epithelial cell differentiation | |
| anagen | |
| endocrine pancreas development | |
| regulation of neuron projection development | |
| positive regulation of blood vessel endothelial cell migration | |
| aging | |
| cell differentiation | |
| positive regulation of fat cell differentiation | |
| striated muscle cell differentiation | |
| execution phase of apoptosis | |
| cell projection organization | |
| positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway | |
| regulation of cell cycle checkpoint | |
| positive regulation of cyclin-dependent protein serine-threonine kinase activity involved in G1-S transition of mitotic cell cycle | |
| signal transduction | |
| intracellular signal transduction | |
| intrinsic apoptotic signaling pathway | |
| protein kinase B signaling | |
| negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress | |
| phosphatidylinositol-mediated signaling | |
| negative regulation of release of cytochrome c from mitochondria | |
| negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | |
| G-protein coupled receptor signaling pathway | |
| neurotrophin TRK receptor signaling pathway | |
| insulin receptor signaling pathway | |
| insulin-like growth factor receptor signaling pathway | |
| fibroblast growth factor receptor signaling pathway | |
| epidermal growth factor receptor signaling pathway | |
| positive regulation of cell growth | |
| negative regulation of plasma membrane long-chain fatty acid transport | |
| regulation of cell migration | |
| apoptotic process | |
| positive regulation of apoptotic process | |
| negative regulation of apoptotic process | |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | |
| apoptotic mitochondrial changes | |
| negative regulation of cell size | |
| positive regulation of endothelial cell proliferation | |
| positive regulation of establishment of protein localization to plasma membrane | |
| carbohydrate transport | |
| protein import into nucleus, translocation | |
| positive regulation of sodium ion transport | |
| glucose transport | |
| positive regulation of glucose import | |
| response to food | |
| cellular response to insulin stimulus | |
| cellular response to growth factor stimulus | |
| cellular response to organic cyclic compound | |
| cellular response to epidermal growth factor stimulus | |
| cellular response to hypoxia | |
| response to hormone | |
| response to fluid shear stress | |
| response to heat | |
| inflammatory response | |
| cellular response to mechanical stimulus | |
| response to UV-A | |
| positive regulation of cellular protein metabolic process | |
| positive regulation of proteasomal ubiquitin-dependent protein catabolic process | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of protein phosphorylation | |
| positive regulation of peptidyl-serine phosphorylation | |
| negative regulation of autophagy | |
| negative regulation of protein kinase activity | |
| negative regulation of proteolysis | |
| regulation of translation | |
| positive regulation of sequence-specific DNA binding transcription factor activity | |
| negative regulation of endopeptidase activity | |
| regulation of protein localization | |
| RNA metabolic process | |
| mRNA metabolic process | |
| nitric oxide biosynthetic process | |
| translation | |
| cellular protein modification process | |
| protein phosphorylation | |
| peptidyl-serine phosphorylation | |
| protein autophosphorylation | |
| protein ubiquitination | |
| phosphorylation | |
| carbohydrate metabolic process | |
| protein catabolic process | |
| hyaluronan metabolic process | |
| gene expression | |
| nitric oxide metabolic process | |
| transport | |
| cytoskeleton organization | |
| glucose homeostasis |
| Pathway | Apoptosis |
|---|---|
| Actin Cytoskeleton Assembly | |
| Telomere Maintenance | |
| Cell Cycle | |
| Tight Junction Assembly (Occludin) | |
| Adherens Junction Assembly (Cadherins) | |
| Androgen Receptor to Protein Kinase C-delta Signaling in Prostate Cancer | |
| Fatty Acid Synthase Signaling in Prostate Cancer | |
| Androgen Receptor to Akt Signaling in Prostate Cancer | |
| Prostate Cancer Overview | |
| Metastatic Colorectal Cancer Overview | |
| Myostatin-IGF1 Crosstalk in Skeletal Muscles | |
| IL6 in Insulin Resistance | |
| Dystrophin Glycoprotein Complex Signaling in Duchenne Muscular Dystrophy | |
| Ca2+ Overload in Duchenne Muscular Dystrophy | |
| Duchenne Muscular Dystrophy Overview | |
| IL6 Promotes Inflammation | |
| IGF1 in Muscle Hypertrophy | |
| Mechanism of Cetuximab Resistance in Colorectal Cancer | |
| RARA Signaling Pathway in Acute Myeloid Leukemia (M3) | |
| FLT3 and KIT Signaling to MLL Pathway in Acute Myeloid Leukemia (M5) | |
| Block of Apoptosis in Acute Myeloid Leukemia | |
| Acute Myeloid Leukemia Overview | |
| Proteins Involved in Pathogenesis of Alzheimer's Disease | |
| Proteins Involved in Pathogenesis of Multiple Myeloma | |
| IL-6/IGF-1/VEGFA in Multiple Myeloma | |
| Osteoclast Activation in Multiple Myeloma | |
| Multiple Myeloma Overview | |
| Proteins Involved in Pathogenesis of Acute Myeloid Leukemia | |
| Proteins Involved in Pathogenesis of Chronic Myeloid Leukemia | |
| Proteins Involved in Pathogenesis of T-cell Acute Lymphoblastic Leukemia | |
| Chronic Myeloid Leukemia Overview | |
| B-cell Acute Lymphoblastic Leukemia Overview | |
| T-cell Acute Lymphoblastic Leukemia Overview | |
| B-cell Chronic Lymphocytic Leukemia Overview | |
| Proteins Involved in Pathogenesis of B-cell Chronic Lymphocytic Leukemia | |
| Proteins Involved in Pathogenesis of Parkinson's Disease | |
| Glutamate in Parkinson's Disease | |
| GLIS3 Targets Possibly Involved in Thyroid Dysgenesis | |
| APP and Glutamate Signaling-Related Neuronal Dysfunction in Alzheimer's Disease | |
| Hodgkin Lymphoma Overview | |
| Diffuse Large-B-cell Lymphoma, ABC Subtype | |
| Diffuse Large-B-cell Lymphoma, GCB Subtype | |
| Diffuse Large-B-cell Lymphoma Overview | |
| Proteins Involved in Pathogenesis of Diffuse Large-B-cell Lymphoma | |
| Follicular Lymphoma Overview | |
| Cowden Syndrome | |
| Dendritic Cells in Psoriasis | |
| IFN-gamma/TNF-alpha Mediated anti-Apoptotic Effect in Psoriatic Keratinocytes | |
| Interleukin-22 Induced Keratinocyte Proliferation in Psoriasis | |
| Mantle Cell Lymphoma Overview | |
| Deregulation of Cell Cycle and DNA Repair in Mantle Cell Lymphoma | |
| Deregulation of Apoptosis in Mantle Cell Lymphoma | |
| PI3K/AKT/MTOR, NF-kB and BCR Signaling Deregulation in Mantle Cell Lymphoma | |
| Hedgehog Signaling in Mantle Cell Lymphoma | |
| Proteins Involved in Pathogenesis of Mantle Cell Lymphoma | |
| Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma Overview | |
| Proteins Involved in Pathogenesis of Breast Cancer Related to ERBB2/VEGFR/Akt Signaling Pathway | |
| Proteins Involved in Pathogenesis of Breast Cancer Related to IGF1R/Akt Signaling Pathway | |
| Breast Cancer Related to IGF1R/Akt Signaling Pathway | |
| Breast Cancer Related to WNT Signaling Pathway | |
| Proteins Involved in Pathogenesis of Breast Cancer Related to WNT Signaling Pathway | |
| Breast Cancer Related to ERBB/VEGFR/Akt Signaling Pathway | |
| Breast Cancer Related to ESR1 Signaling Pathway | |
| Proteins Involved in Pathogenesis of Breast Cancer Related to ESR1 Signaling Pathway | |
| ESR1/ERBB-positive Luminal Breast Cancer | |
| Basal Breast Cancer | |
| Activation of nNOS (NOS1) and iNOS (NOS2) via Glutamate in Familial Hemiplegic Migraine | |
| Proliferative Diabetic Retinopathy | |
| Insulin Influence on Glycogenesis | |
| Obesity Induced Insulin Resistance in Myocytes | |
| Insulin Resistance in Hepatocytes | |
| Role of Protein Kinase C in Diabetic Microangiopathy | |
| Insulin Influence on Protein Synthesis | |
| Proteins Involved in Pathogenesis of Insulin Resistance | |
| Impaired Adiponectin Synthesis in Insulin Resistance | |
| Role of Adiponectin in Insulin Resistance Prevention | |
| Proteins Involved in Pathogenesis of Diabetes Mellitus Type 2 | |
| Role of Advanced Glycation End Products Pathway in Diabetic Microangiopathy | |
| Peripheral Tissue Microangiopathy in Insulin Resistance | |
| Congenital Hypothyroidism Due to Thyroid-Stimulating Hormone Resistance | |
| Graves Ophthalmopathy | |
| Thyroid Dysfunction in Graves Disease | |
| Cardiovascular Effects of Hyperthyroidism | |
| Common Non-genomic Effects of Thyroid Hormones | |
| Effects of Hyperthyroidism on Bone Remodeling | |
| Immune System Activation in Graves Disease Overview | |
| Primary Overt Hypothyroidism Overview | |
| Clear Cell Ovarian Carcinoma | |
| Proteins Involved in Pathogenesis of Clear Cell Ovarian Carcinoma | |
| Mucinous Ovarian Carcinoma | |
| High-grade Serous Ovarian Carcinoma | |
| Proteins Involved in Pathogenesis of Mucinous Ovarian Carcinoma | |
| Proteins Involved in Pathogenesis of High-grade Serous Ovarian Carcinoma | |
| Endometrioid Ovarian Carcinoma | |
| Proteins Involved in Pathogenesis of Endometrioid Ovarian Carcinoma | |
| Proteins Overexpressed in Ovarian Cancer | |
| Ovarian Cancer Overview | |
| Low-grade Serous Ovarian Carcinoma | |
| Proteins Involved in Pathogenesis of Low-grade Serous Ovarian Carcinoma | |
| Type I Endometrial Cancer (Endometrioid Endometrial Cancer) | |
| Type II Endometrial Cancer (Clear-cell Endometrial Cancer and Papillary Serous Endometrial Cancer) | |
| Proteins Involved in Pathogenesis of Endometrial Cancer | |
| Endometrial Cancer Overview | |
| Block of Apoptosis in Melanoma | |
| Dedifferentiation and Metastatic Progression of Melanoma | |
| Proteins Involved in Pathogenesis of Melanoma | |
| Melanoma Overview | |
| Th1 Cell Function in Systemic Lupus Erythematosus | |
| Th2 Cell Function in Systemic Lupus Erythematosus | |
| B-cell Activation in Systemic Lupus Erythematosus | |
| Th0 Cell Aberrant Activation in Systemic Lupus Erythematosus | |
| Proteins Involved in Pathogenesis of Prostate Cancer | |
| T-cell-Dependent B-cell Activation | |
| T-cell-Independent B-cell Activation | |
| Natural Killer Cell Activation through C-type Lectin-like Receptors | |
| Toll-like Receptors Act through MYD88-TIRAP Signaling | |
| Central T-cell Tolerance | |
| Peripheral T-cell Tolerance Overview | |
| Model of T-cell Maturation | |
| T-cell Positive Selection and Neglect-Induced Death | |
| CD8+ T-cell Activation | |
| Th17 Cell Differentiation | |
| Th1 Cell Differentiation | |
| T-cell Receptor Signaling | |
| Regulatory T-cell Differentiation | |
| Th2 Cell Differentiation | |
| Cancer Overview | |
| NO Synthesis in Early Vasospasm | |
| Activation and Proliferation of Th1 Cells in Atherosclerosis | |
| RAGE/AGER and S100 Proteins in Cardiovascular Injury in Atherosclerosis | |
| Onset of Atopic Dermatitis | |
| Proteins Involved in Pathogenesis of Hypertrophic Cardiomyopathy | |
| Mechanisms of Cardiomyocyte Hypertrophy in Hypertrophic Cardiomyopathy | |
| Hypertrophic Cardiomyopathy Overview | |
| BMP2 Activates WNT Signaling in Pulmonary Artery Smooth Muscle Cells | |
| Primary Glioblastoma | |
| Secondary Glioblastoma | |
| Proteins Involved in Pathogenesis of Glioblastoma | |
| Activation of Glioma Stem Cell Program | |
| Glioma Invasion Signaling | |
| Proteins Involved in Pathogenesis of Glioma | |
| Proteins Involved in Pathogenesis of Astrocytoma | |
| Ependymoma | |
| Astrocytoma | |
| Medulloblastoma Overview | |
| Proteins Involved in Pathogenesis of Medulloblastoma | |
| Block of CD4+ T-cell Signaling in HIV Type 1 Infection | |
| Macrophage Survival through CCR5 and CXCR4 Mediated Signaling in HIV Type 1 Infection | |
| Proteins Involved in Pathogenesis of Osteoarthritis | |
| Osteoarthritis Overview | |
| Mutations in EPHA2 Cause Cataract | |
| Steroid-Induced Cataract | |
| Sonic Hedgehog Signaling in Neuroblastoma | |
| Growth Factor Signaling in Neuroblastoma | |
| ALK-Associated Neuroblastoma | |
| Proteins Involved in Pathogenesis of Neuroblastoma | |
| Neuroblastoma Overview | |
| Growth Factor Signaling in Pancreatic Cancer | |
| STK11 Signaling in Pancreatic Cancer | |
| Pancreatic Ductal Carcinoma | |
| Proteins Involved in Pathogenesis of Pancreatic Cancer | |
| Pancreatic Neuroendocrine Tumors | |
| Proteins Involved in Pathogenesis of Polycystic Ovary Syndrome | |
| Impaired SHBG and IGFBP1 Synthesis in Polycystic Ovary Syndrome | |
| FSH Action in Polycystic Ovary Syndrome | |
| Block of Ovulation in Polycystic Ovary Syndrome | |
| Polycystic Ovary Syndrome Overview | |
| Peutz-Jeghers Syndrome Overview | |
| Growth Factor Signaling in Hepatocellular Carcinoma | |
| Proteins Involved in Pathogenesis of Hepatocellular Carcinoma | |
| Hepatocellular Carcinoma Overview | |
| Osteoclast Activation in Gout | |
| Glutamate-Mediated Excitotoxicity in Amyotrophic Lateral Sclerosis | |
| Proteins Involved in Pathogenesis of Amyotrophic Lateral Sclerosis | |
| Impairment of Microglia Inhibition by Motor Neuron in Amyotrophic Lateral Sclerosis | |
| Osteoclast Activation in Rheumatoid Arthritis | |
| Proteins Involved in Pathogenesis of Rheumatoid Arthritis | |
| Induction of Apoptosis and Immediate Early Gene Activation in Hippocampal Neurons Following Seizures | |
| Epilepsies Associated with Blood-Brain Barrier Disruption | |
| mTOR Hyperactivation after Status Epilepticus | |
| Proposed Mechanisms of Antiepileptic Effects of a Ketogenic Diet | |
| Regulation of Vascular Reactivity in Raynaud Disease | |
| B-cells Function in Systemic Scleroderma | |
| Role of Th2 cells in Systemic Scleroderma | |
| Proteins Involved in Pathogenesis of Myocardial Ischemia | |
| Myocardial Remodeling in Myocardial Ischemia | |
| Preconditioning Ischemia | |
| Myocardial Infarction | |
| WHIM Syndrom Overview | |
| BDKRB1/2 -> interleukins production | |
| BDKRB1/2 -> vasodilation | |
| PTGER2/3 -> vascular motility | |
| DRD2 -> TRPC1 transcription | |
| TACR1 -> TNF/IL6/IL8 production | |
| GALR1/2/3 -> POMC/NPY production | |
| Leptin -> NO production/vasodilation | |
| Regulation of sodium flux | |
| Summarized nociception-related expression targets | |
| Summarized vascular motility pathway | |
| PDGFR -> FOXO3A signaling | |
| VEGFR -> FOXO3A signaling | |
| HGFR -> FOXO3A signaling | |
| ErythropoietinR -> FOXO3A signaling | |
| TNFRSF5/13B -> NFATC1 signaling | |
| Notch -> NF-kB signaling | |
| TLR1/2/6 -> NF-kB signaling | |
| AGER -> NF-kB signaling | |
| EGFR/ERBB2 -> HIF1A signaling | |
| VEGFR -> CTNNB signaling | |
| InsulinR -> CTNNB/FOXA/FOXO signaling | |
| InsulinR -> ELK-SRF/SREBF signaling | |
| IGF1R -> CEBPA/FOXO1A signaling | |
| GDNF -> HSF1 signaling | |
| AngiopoietinR -> FOXO signaling | |
| NTRK -> FOXO/MYCN signaling | |
| DDR1 -> NF-kB signaling | |
| MacrophageR -> CEBPB/NF-kB signaling | |
| FibronectinR -> CTNNB signaling | |
| ICAM2 -> CTNNB/FOXO/STAT3 signaling | |
| FibronectinR -> NF-kB signaling | |
| CD19 -> NF-kB signaling | |
| IL7R -> FOXO/NF-kB signaling | |
| IL12R -> NF-kB/NFATC signaling | |
| IL15R -> NF-kB/NFATC signaling | |
| ThrombopoietinR -> SPI1 signaling | |
| ErythropoietinR -> NF-kB signaling | |
| GHR -> NF-kB signaling | |
| DopamineR2 -> NF-kB signaling | |
| PTAFR -> NF-kB signaling | |
| AdenosineR -> NF-kB signaling | |
| AdrenergicRb -> STAT3 signaling | |
| FSHR -> FOXO1A signaling | |
| ThrombinR -> NF-kB signaling | |
| CD38 -> NF-kB signaling | |
| Cyclosporine-Induced Nephrotoxicity | |
| ER Stress (Unfolded Protein Response) | |
| Dexamethasone-Induced Diabetes | |
| Dexamethasone-Induced Osteoporosis | |
| Doxorubicin-Induced Cardiotoxicity | |
| Cytosolic Calcium Overload | |
| Clozapine-Induced Granulocytopenia | |
| Glutamate-Mediated Excitotoxicity | |
| Tamoxifen-Induced Endometrial Cancer | |
| Ritonavir-Induced Diabetes | |
| ROS in Angiotensin-Mediated Cardiovascular Remodeling and Hypertrophy | |
| TLR1/2/6 Expression Targets | |
| NGF/FOXO/MYCN/ELK-SRF Expression Targets | |
| BDNF Expression Targets | |
| NTF3 Expression Targets | |
| DLL1 Expression Targets | |
| DLL4 Expression Targets | |
| ADAM17 Expression Targets | |
| CD40LG/NF-kB/ELK-SRF/CREB/NFATC Expression Targets | |
| JAG1 Expression Targets | |
| TNFSF13B Expression Targets | |
| TNFSF10 Expression Targets | |
| TNF/STAT Expression Targets | |
| ICAM1 Expression Targets | |
| Fibrinogen Expression Targets | |
| Fibronectin Expression Targets | |
| CD21 Expression Targets | |
| PECAM1 Expression Targets | |
| CD19 Expression Targets | |
| CD81 Expression Targets | |
| IL12B Expression Targets | |
| IL15 Expression Targets | |
| IL7 Expression Targets | |
| Thrombopoietin/SPI1 Expression Targets | |
| Erythropoietin/NF-kB Expression Targets | |
| GH1-GHR/NF-kB/ELK-SRF/MYC Expression Targets | |
| PRL-GHR/NF-kB/ELK-SRF/MYC Expression Targets | |
| CSH1-GHR Expression Targets | |
| CCL3 Expression Targets | |
| CCL4 Expression Targets | |
| CCL5 Expression Targets | |
| IL8 Expression Targets | |
| Dopamine/Gi Expression Targets | |
| S100B Expression Targets | |
| S100P Expression Target | |
| HMGB1 Expression Targets | |
| TTR Expression Targets | |
| AREG/HIF1A Expression Targets | |
| EGF/HIF1A Expression Targets | |
| EREG/HIF1A Expression Target | |
| HBEGF/HIF1A Expression Targets | |
| NRG1/HIF1A Expression Target | |
| TGFA/HIF1A Expression Targets | |
| VEGFA/CTNNB/CTNND Expression Targets | |
| VEGFC/CTNNB Expression Target | |
| Collagen/NF-kB Expression Targets | |
| GDNF/HSF1 Expression Targets | |
| IGF2/CEBPA/FOXO1A Expression Targets | |
| CTGF/FOXO3A Expression Target | |
| Erythropoietin/FOXO3A Expression Targets | |
| Thrombopoietin/FOXO3A Expression Target | |
| AREG/FOXO3A Expression Target | |
| EGF/FOXO3A Expression Targets | |
| EREG/FOXO3A Expression Target | |
| HBEGF/FOXO3A Expression Target | |
| NRG1/FOXO3A Expression Targets | |
| TGFA/FOXO3A Expression Targets | |
| FGF2/FOXO3A Expression Targets | |
| FGF7/FOXO3A Expression Target | |
| FGF10/FOXO3A Expression Target | |
| CSF1/FOXO3A Expression Targets | |
| PDGFB/FOXO3A Expression Target | |
| VEGFA/FOXO3A Expression Targets | |
| HGF/FOXO3A Expression Targets | |
| PDGF/FOXO3A Expression Targets | |
| F2 -> STAT1/NF-kB Expression Targets | |
| PLG -> STAT1/NF-kB Expression Targets | |
| Adenosine Expression Targets | |
| PAF/Gq -> NF-kB Expression Targets | |
| Epinephrine/Gs Expression Targets | |
| Noradrenaline/Gs Expression Targets | |
| FSHR Expression Targets | |
| PDCD1/STAT Expression Targets | |
| PDCD1/ATF/CREB/CREBBP Expression Targets | |
| IGF1/CEBPA/FOXO1A Expression Targets | |
| Insulin/ELK-SRF/HIF1A/MYC/SREBF Expression Targets | |
| NOTCH Expression Targets | |
| Insulin/CEBPA/CTNNB/FOXA/FOXO Expression Targets | |
| non-small cell lung cancer pathway | |
| phosphatidylinositol 3-kinase-Akt signaling pathway | |
| phosphatidylinositol 3-kinase-Akt signaling pathway | |
| phosphatidylinositol 3-kinase-Akt signaling pathway |
| Group | AKT |
|---|---|
| Oncogenes | |
| germ cell development | |
| maternal placenta development | |
| activation-induced cell death of T cells | |
| innate immune response | |
| Fc-epsilon receptor signaling pathway | |
| T cell costimulation | |
| cell proliferation | |
| small molecule metabolic process | |
| glycogen biosynthetic process | |
| positive regulation of glycogen biosynthetic process | |
| regulation of glycogen biosynthetic process | |
| positive regulation of lipid biosynthetic process | |
| negative regulation of JNK cascade | |
| negative regulation of fatty acid beta-oxidation | |
| glycogen metabolic process | |
| glucose metabolic process | |
| positive regulation of glucose metabolic process | |
| positive regulation of nitric-oxide synthase activity | |
| nitric-oxide synthase regulator activity | |
| regulation of nitric-oxide synthase activity | |
| multicellular organismal development | |
| osteoblast differentiation | |
| positive regulation of vasoconstriction | |
| blood coagulation | |
| platelet activation | |
| peripheral nervous system myelin maintenance | |
| nervous system development | |
| labyrinthine layer blood vessel development | |
| glycogen cell differentiation involved in embryonic placenta development | |
| mammary gland epithelial cell differentiation | |
| anagen | |
| endocrine pancreas development | |
| regulation of neuron projection development | |
| positive regulation of blood vessel endothelial cell migration | |
| aging | |
| cell differentiation | |
| positive regulation of fat cell differentiation | |
| striated muscle cell differentiation | |
| execution phase of apoptosis | |
| cell projection organization | |
| positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway | |
| regulation of cell cycle checkpoint | |
| positive regulation of cyclin-dependent protein serine-threonine kinase activity involved in G1-S transition of mitotic cell cycle | |
| signal transduction | |
| intracellular signal transduction | |
| intrinsic apoptotic signaling pathway | |
| protein kinase B signaling | |
| negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress | |
| phosphatidylinositol-mediated signaling | |
| negative regulation of release of cytochrome c from mitochondria | |
| negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | |
| G-protein coupled receptor signaling pathway | |
| neurotrophin TRK receptor signaling pathway | |
| insulin receptor signaling pathway | |
| insulin-like growth factor receptor signaling pathway | |
| fibroblast growth factor receptor signaling pathway | |
| epidermal growth factor receptor signaling pathway | |
| positive regulation of cell growth | |
| negative regulation of plasma membrane long-chain fatty acid transport | |
| regulation of cell migration | |
| apoptotic process | |
| positive regulation of apoptotic process | |
| negative regulation of apoptotic process | |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | |
| apoptotic mitochondrial changes | |
| negative regulation of cell size | |
| positive regulation of endothelial cell proliferation | |
| positive regulation of establishment of protein localization to plasma membrane | |
| carbohydrate transport | |
| protein import into nucleus, translocation | |
| positive regulation of sodium ion transport | |
| glucose transport | |
| positive regulation of glucose import | |
| response to food | |
| cellular response to insulin stimulus | |
| cellular response to growth factor stimulus | |
| cellular response to organic cyclic compound | |
| cellular response to epidermal growth factor stimulus | |
| cellular response to hypoxia | |
| response to hormone | |
| response to fluid shear stress | |
| response to heat | |
| inflammatory response | |
| cellular response to mechanical stimulus | |
| response to UV-A | |
| positive regulation of cellular protein metabolic process | |
| positive regulation of proteasomal ubiquitin-dependent protein catabolic process | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of protein phosphorylation | |
| positive regulation of peptidyl-serine phosphorylation | |
| negative regulation of autophagy | |
| negative regulation of protein kinase activity | |
| negative regulation of proteolysis | |
| regulation of translation | |
| positive regulation of sequence-specific DNA binding transcription factor activity | |
| negative regulation of endopeptidase activity | |
| regulation of protein localization | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| RNA metabolic process | |
| mRNA metabolic process | |
| nitric oxide biosynthetic process | |
| translation | |
| cellular protein modification process | |
| protein phosphorylation | |
| peptidyl-serine phosphorylation | |
| protein autophosphorylation | |
| protein ubiquitination | |
| phosphorylation | |
| carbohydrate metabolic process | |
| protein catabolic process | |
| hyaluronan metabolic process | |
| gene expression | |
| nitric oxide metabolic process | |
| transport | |
| cytoskeleton organization | |
| glucose homeostasis | |
| 14-3-3 protein binding | |
| enzyme binding | |
| protein kinase binding | |
| protein kinase C binding | |
| nucleotide binding | |
| ATP binding | |
| phosphatidylinositol-3,4,5-trisphosphate binding | |
| phosphatidylinositol-3,4-bisphosphate binding | |
| membrane | |
| nucleoplasm | |
| spindle | |
| intracellular | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| mitochondrion | |
| microtubule cytoskeleton | |
| nucleus | |
| lamellipodium | |
| Genes with Mutations Associated with Cowden Syndrome | |
| Proteins Involved in Pathogenesis of Cowden Syndrome | |
| Secreted proteins | |
| Biofluids assayable substances |
| Source | Curated |
|---|
| LocusLink ID | 207 |
|---|---|
| 11651 | |
| 24185 | |
| 50586 |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus | |
| Cell membrane |
| GO ID | 0071889 |
|---|---|
| 0005524 | |
| 0019899 | |
| 0016301 | |
| 0030235 | |
| 0005547 | |
| 0043325 | |
| 0005080 | |
| 0004672 | |
| 0004674 | |
| 0038095 | |
| 0007186 | |
| 0016070 | |
| 0031295 | |
| 0006924 | |
| 0007568 | |
| 0042640 | |
| 0008637 | |
| 0006915 | |
| 0007596 | |
| 0030154 | |
| 0030030 | |
| 0008283 | |
| 0006464 | |
| 0071364 | |
| 0071456 | |
| 0032869 | |
| 0031018 | |
| 0007173 | |
| 0008543 | |
| 0010467 | |
| 0007281 | |
| 0042593 | |
| 0006006 | |
| 0015758 | |
| 0005978 | |
| 0060709 | |
| 0006954 | |
| 0045087 | |
| 0008286 | |
| 0048009 | |
| 0035556 | |
| 0097193 | |
| 0060716 | |
| 0016071 | |
| 0060644 | |
| 0001893 | |
| 0046329 | |
| 0043066 | |
| 0010507 | |
| 0045792 | |
| 0043154 | |
| 0010951 | |
| 2001240 | |
| 0031999 | |
| 1902176 | |
| 0010748 | |
| 0006469 | |
| 0045861 | |
| 0090201 | |
| 0048011 | |
| 0006809 | |
| 0046209 | |
| 0001649 | |
| 0018105 | |
| 0032287 | |
| 0048015 | |
| 0016310 | |
| 0030168 | |
| 0043065 | |
| 0043536 | |
| 0030307 | |
| 0032270 | |
| 0031659 | |
| 0001938 | |
| 0090004 | |
| 0045600 | |
| 0046326 | |
| 0010907 | |
| 0045725 | |
| 0046889 | |
| 0045429 | |
| 0051000 | |
| 0033138 | |
| 0032436 | |
| 1900740 | |
| 0001934 | |
| 0051091 | |
| 0010765 | |
| 0045944 | |
| 0045907 | |
| 0046777 | |
| 0030163 | |
| 0000060 | |
| 0043491 | |
| 0006468 | |
| 0016567 | |
| 1901976 | |
| 0030334 | |
| 0005979 | |
| 0010975 | |
| 0050999 | |
| 0006417 | |
| 0070141 | |
| 0034405 | |
| 0032094 | |
| 0009408 | |
| 0007165 | |
| 0044281 | |
| 0051146 | |
| 0006412 | |
| 0005737 | |
| 0005829 | |
| 0030027 | |
| 0015630 | |
| 0005654 | |
| 0005634 | |
| 0005886 | |
| 0005819 | |
| 0000166 | |
| 0019901 | |
| 0016740 | |
| 0016772 | |
| 0005975 | |
| 0008643 | |
| 0071363 | |
| 0071260 | |
| 0071407 | |
| 0007010 | |
| 0097194 | |
| 0005977 | |
| 0007275 | |
| 0007399 | |
| 0032880 | |
| 0009725 | |
| 0006810 | |
| 0005622 | |
| 0016020 | |
| 0005739 | |
| 0030212 | |
| 0008633 | |
| 2001047 | |
| 0005543 | |
| 0006916 | |
| 0045768 | |
| 0045884 | |
| 0023034 | |
| 0001764 | |
| 0005625 | |
| 0005856 | |
| 0042802 | |
| 0005351 | |
| 0001568 | |
| 0007242 | |
| 0001890 | |
| 0040018 | |
| 0070201 | |
| 0005515 | |
| 0006445 | |
| 0004713 | |
| 0000074 | |
| 0050875 | |
| 0004702 |
| Alias | AKT |
|---|---|
| PKB | |
| RAC | |
| CWS6 | |
| PRKBA | |
| PKB-ALPHA | |
| RAC-ALPHA | |
| RAC-alpha serine/threonine-protein kinase | |
| PKB alpha | |
| RAC-PK-alpha | |
| proto-oncogene c-Akt | |
| protein kinase B alpha | |
| rac protein kinase alpha | |
| PKB/Akt | |
| PKBalpha | |
| AKT1 kinase | |
| protein kinase B-alpha | |
| related to A and C kinases | |
| thymoma viral proto-oncogene 1 | |
| RAC protein kinase alpha RAC-PK alpha | |
| murine thymoma viral (v-akt) oncogene homolog 1 | |
| Akt kinase | |
| Protein kinase B | |
| proto-oncogene proteins c-akt | |
| RAC-alpha serine/threonine kinase | |
| serine/threonine protein kinase B | |
| thymoma viral proto-oncogene | |
| thymoma viral proto-oncogene 1; thymoma viral proto-oncogene | |
| thymoma viral proto-oncogene I | |
| v-akt murine thymoma viral oncogene homolog I | |
| protein kinase Akt | |
| protooncogene protein c akt | |
| PKB/Akts | |
| v-akt murine thymoma viral oncogene homolog 1 | |
| Akt I | |
| 6.1a protein | |
| Akt/PKB | |
| Akt/PKBs | |
| Akt1 | |
| AKTI | |
| C6.1A | |
| C-AKT | |
| OTTMUSP00000022947 | |
| LOC217879 | |
| OTTMUSP00000022949 | |
| OTTMUSP00000022944 | |
| Murine thymoma viral (v-akt) oncogene homolog I | |
| MGC99656 | |
| MGC29148 | |
| LOC268604 | |
| murine thymoma viral (v-akt) oncogene homolog-1 |
| Mouse chromosome position | 12 61.2 cM |
|---|---|
| 12 57.0 cM |
| OMIM ID | 164730 |
|---|---|
| 615109 | |
| 114480 | |
| 114500 | |
| 167000 | |
| 176920 | |
| 181500 | |
| 604370 |
| Rat chromosome position | 6q32 |
|---|
| Hugo ID | 391 |
|---|
| Human chromosome position | 14q32.32 |
|---|
| Swiss-Prot Accession | B0LPE5 |
|---|---|
| P31749 | |
| B3KVH4 | |
| P31750 | |
| P47196 | |
| Q62274 | |
| Q6GSA6 | |
| B2RAM5 | |
| Q9BWB6 | |
| Q9BV07 | |
| Q8BS26 | |
| Q6ZMW5 |
| PIR ID | JC2437 |
|---|---|
| S33364 | |
| A39360 |
| Unigene ID | Hs.525622 |
|---|---|
| Mm.6645 | |
| Rn.11422 |
| KEGG ID | hsa:207 |
|---|---|
| mmu:11651 | |
| rno:24185 |
| Swiss-Prot ID | AKT1_RAT |
|---|---|
| AKT1_MOUSE | |
| AKT1_HUMAN | |
| B0LPE5_HUMAN | |
| B3KVH4_HUMAN | |
| Q6GSA6_MOUSE |
| EC Number | 2.7.11.1 |
|---|---|
| 2.7.1.37 |
| Ensembl ID | ENSG00000142208 |
|---|---|
| ENSP00000384293 | |
| ENST00000407796 | |
| ENSP00000270202 | |
| ENST00000349310 | |
| ENSP00000450688 | |
| ENST00000555528 | |
| ENSMUSG00000001729 | |
| ENSMUSP00000001780 | |
| ENSMUST00000001780 | |
| ENSRNOG00000028629 | |
| ENSRNOP00000038369 | |
| ENSRNOT00000031164 |
| Homologene ID | 3785 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 87986 |
|---|
| RGD ID | 2081 |
|---|
| MedScan ID | 207 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00212844 |
|---|---|
| IPI00012866 | |
| IPI00323969 | |
| IPI00556735 |
| KEGG pathway | Insulin signaling pathway |
|---|---|
| B cell receptor signaling pathway | |
| Apoptosis | |
| Jak-STAT signaling pathway | |
| Focal adhesion | |
| Tight junction | |
| Toll-like receptor signaling pathway | |
| MAPK signaling pathway | |
| T cell receptor signaling pathway | |
| Adipocytokine signaling pathway |