| URN | urn:agi-llid:4233 |
|---|---|
| Connectivity | 558 |
| Name | Met |
| Description | met proto-oncogene |
| Notes | hepatocyte growth factor receptor; functions as a heterodimeric tyrosine kinase [RGD] |
| Pathway | HGFR -> AP-1/CREB/MYC signaling |
|---|---|
| HGFR -> FOXO3A signaling | |
| HGFR -> STAT signaling | |
| scatter factor-hepatocyte growth factor signaling pathway | |
| non-small cell lung cancer pathway | |
| pancreatic cancer pathway |
| GO Molecular Function | nucleotide binding |
|---|---|
| transferase activity | |
| beta-catenin binding | |
| phospholipase binding | |
| protein heterodimerization activity | |
| phosphoinositide 3-kinase binding | |
| ATP binding | |
| kinase activity | |
| protein kinase activity | |
| protein tyrosine kinase activity | |
| transmembrane receptor protein tyrosine kinase activity | |
| hepatocyte growth factor receptor activity | |
| receptor activity |
| GO Cellular Component | postsynaptic membrane |
|---|---|
| postsynaptic density | |
| membrane | |
| excitatory synapse | |
| extracellular space | |
| plasma membrane | |
| neuron projection | |
| flagellum | |
| neuronal cell body | |
| cytoplasm | |
| membrane fraction | |
| basal plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| dendrite |
| GO Biological Process | cell proliferation |
|---|---|
| myoblast proliferation | |
| cell aging | |
| multicellular organismal development | |
| adult behavior | |
| ovarian follicle cell development | |
| male gonad development | |
| muscle organ development | |
| brain development | |
| pancreas development | |
| liver development | |
| placenta development | |
| positive regulation of dendrite morphogenesis | |
| positive regulation of neuron projection development | |
| skeletal muscle tissue development | |
| myotube differentiation | |
| oligodendrocyte development | |
| central nervous system neuron differentiation | |
| regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling | |
| lactation | |
| signal transduction | |
| positive regulation of mitosis | |
| activation of MAPK activity | |
| negative regulation of gene-specific transcription from RNA polymerase II promoter | |
| negative regulation of peptidyl-threonine phosphorylation | |
| positive regulation of DNA replication | |
| positive regulation of gene-specific transcription from RNA polymerase II promoter | |
| positive regulation of peptidyl-serine phosphorylation | |
| positive regulation of peptidyl-threonine phosphorylation | |
| sperm motility | |
| muscle cell migration | |
| neuron migration | |
| protein amino acid phosphorylation | |
| protein amino acid autophosphorylation | |
| cellular response to inorganic substance | |
| cellular response to growth factor stimulus | |
| cellular response to arsenic | |
| cellular response to peptide hormone stimulus | |
| cellular response to interleukin-6 | |
| cellular response to glucose stimulus | |
| response to drug | |
| response to acid | |
| response to wounding | |
| response to organic cyclic substance | |
| response to protein stimulus | |
| response to peptide hormone stimulus | |
| positive regulation of gene expression | |
| cell surface receptor linked signaling pathway | |
| transmembrane receptor protein tyrosine kinase signaling pathway | |
| hepatocyte growth factor receptor signaling pathway |
| Ariadne Ontology | GFR |
|---|---|
| Oncogenes |
| Group | GFR |
|---|---|
| Oncogenes | |
| cell proliferation | |
| myoblast proliferation | |
| cell aging | |
| multicellular organismal development | |
| adult behavior | |
| ovarian follicle cell development | |
| male gonad development | |
| muscle organ development | |
| brain development | |
| pancreas development | |
| liver development | |
| placenta development | |
| positive regulation of dendrite morphogenesis | |
| positive regulation of neuron projection development | |
| skeletal muscle tissue development | |
| myotube differentiation | |
| oligodendrocyte development | |
| central nervous system neuron differentiation | |
| regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling | |
| lactation | |
| signal transduction | |
| positive regulation of mitosis | |
| activation of MAPK activity | |
| negative regulation of gene-specific transcription from RNA polymerase II promoter | |
| negative regulation of peptidyl-threonine phosphorylation | |
| positive regulation of DNA replication | |
| positive regulation of gene-specific transcription from RNA polymerase II promoter | |
| positive regulation of peptidyl-serine phosphorylation | |
| positive regulation of peptidyl-threonine phosphorylation | |
| sperm motility | |
| muscle cell migration | |
| neuron migration | |
| protein amino acid phosphorylation | |
| protein amino acid autophosphorylation | |
| cellular response to inorganic substance | |
| cellular response to growth factor stimulus | |
| cellular response to arsenic | |
| cellular response to peptide hormone stimulus | |
| cellular response to interleukin-6 | |
| cellular response to glucose stimulus | |
| response to drug | |
| response to acid | |
| response to wounding | |
| response to organic cyclic substance | |
| response to protein stimulus | |
| response to peptide hormone stimulus | |
| positive regulation of gene expression | |
| cell surface receptor linked signaling pathway | |
| transmembrane receptor protein tyrosine kinase signaling pathway | |
| hepatocyte growth factor receptor signaling pathway | |
| nucleotide binding | |
| transferase activity | |
| beta-catenin binding | |
| phospholipase binding | |
| protein heterodimerization activity | |
| phosphoinositide 3-kinase binding | |
| ATP binding | |
| kinase activity | |
| protein kinase activity | |
| protein tyrosine kinase activity | |
| transmembrane receptor protein tyrosine kinase activity | |
| hepatocyte growth factor receptor activity | |
| receptor activity | |
| postsynaptic membrane | |
| postsynaptic density | |
| membrane | |
| excitatory synapse | |
| extracellular space | |
| plasma membrane | |
| neuron projection | |
| flagellum | |
| neuronal cell body | |
| cytoplasm | |
| membrane fraction | |
| basal plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| dendrite |
| MedScan ID | 4233 |
|---|
| Hugo ID | 7029 |
|---|
| Human chromosome position | 7q31 |
|---|
| LocusLink ID | 4233 |
|---|---|
| 17295 | |
| 24553 |
| Alias | HGFR |
|---|---|
| AUTS9 | |
| RCCP2 | |
| c-Met | |
| hepatocyte growth factor receptor | |
| SF receptor | |
| HGF receptor | |
| oncogene MET | |
| HGF/SF receptor | |
| proto-oncogene c-Met | |
| scatter factor receptor | |
| tyrosine-protein kinase Met | |
| met proto-oncogene tyrosine kinase | |
| HGF | |
| Par4 | |
| AI838057 | |
| OTTMUSP00000028498 | |
| OTTMUSP00000028499 | |
| c-Met receptor | |
| c-Met receptors | |
| Hepatocyte growth factor receptors | |
| Hepatocyte growth factor/scatter factor receptor | |
| HGF R | |
| HGF receptors | |
| HGF/SF receptors | |
| HGF-SF receptor | |
| LOC194383 | |
| LOC360378 | |
| LOC367980 | |
| LOC368085 | |
| LOC497783 | |
| MET | |
| MET Oncogene | |
| Met protein | |
| Met proto- oncogene tyrosine kinase | |
| met proto-onco | |
| met proto-oncogene | |
| met proto-oncogene (hepatocyte growth factor receptor) | |
| met proto-oncogene (hepatocyte growth factor receptor)s | |
| Met receptor | |
| Met receptors | |
| MET_HUMAN | |
| OTTHUMP00000069168 | |
| protein Met | |
| receptor Met | |
| pulmonary adenoma resistance 4 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 164860 |
|---|---|
| 611015 | |
| 114550 | |
| 605074 |
| Mouse chromosome position | 6 4.0 cM |
|---|
| GO ID | 0005524 |
|---|---|
| 0005008 | |
| 0000166 | |
| 0004713 | |
| 0004872 | |
| 0016740 | |
| 0008283 | |
| 0007166 | |
| 0007275 | |
| 0006468 | |
| 0007165 | |
| 0009925 | |
| 0016021 | |
| 0005887 | |
| 0005886 | |
| 0008013 | |
| 0016301 | |
| 0043548 | |
| 0043274 | |
| 0046982 | |
| 0004672 | |
| 0004714 | |
| 0000187 | |
| 0030534 | |
| 0007420 | |
| 0048012 | |
| 0001889 | |
| 0014812 | |
| 0007517 | |
| 0051450 | |
| 0014902 | |
| 0010553 | |
| 0010801 | |
| 0001764 | |
| 0001890 | |
| 0045740 | |
| 0050775 | |
| 0010628 | |
| 0010552 | |
| 0045840 | |
| 0010976 | |
| 0033138 | |
| 0010800 | |
| 0046777 | |
| 0060665 | |
| 0007519 | |
| 0030317 | |
| 0007169 | |
| 0005737 | |
| 0030425 | |
| 0060076 | |
| 0005615 | |
| 0019861 | |
| 0016020 | |
| 0005624 | |
| 0043005 | |
| 0043025 | |
| 0014069 | |
| 0045211 | |
| 0007569 | |
| 0071243 | |
| 0071333 | |
| 0071363 | |
| 0071241 | |
| 0071354 | |
| 0071375 | |
| 0021953 | |
| 0007595 | |
| 0008584 | |
| 0014003 | |
| 0030707 | |
| 0031016 | |
| 0001101 | |
| 0042493 | |
| 0014070 | |
| 0043434 | |
| 0051789 | |
| 0009611 | |
| 0005515 | |
| 0003779 | |
| 0004871 | |
| 0007223 | |
| 0030036 | |
| 0051016 | |
| 0008290 | |
| 0005794 | |
| 0000139 | |
| 0005576 | |
| 0005578 | |
| 0004674 |
| Rat chromosome position | 4q21 |
|---|
| Swiss-Prot Accession | A1L467 |
|---|---|
| P08581 | |
| Q14825 | |
| Q59EB3 | |
| Q9UEJ3 | |
| Q9UMU9 | |
| A4FUV6 | |
| P16056 | |
| Q3TCS4 | |
| Q6Q531 | |
| Q6Q532 | |
| Q6Q533 | |
| P97523 | |
| O35515 | |
| Q2IBC7 | |
| Q99MC5 | |
| P97579 | |
| Q63119 | |
| Q63964 | |
| O60366 | |
| Q12875 | |
| Q9UDX7 | |
| Q9UPL8 |
| PIR ID | PC2131 |
|---|---|
| A40175 |
| Unigene ID | Hs.132966 |
|---|---|
| Mm.86844 | |
| Rn.10617 |
| KEGG ID | hsa:4233 |
|---|---|
| mmu:17295 | |
| rno:24553 |
| EC Number | 2.7.10.1 |
|---|
| Swiss-Prot ID | MET_RAT |
|---|---|
| MET_HUMAN | |
| A1L467_HUMAN | |
| A4FUV6_MOUSE |
| Cell Localization | Membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00326236 |
|---|---|
| IPI00029273 | |
| IPI00294528 | |
| IPI00130420 | |
| IPI00884102 | |
| IPI00795476 | |
| IPI00852650 | |
| IPI00892811 | |
| IPI00853590 | |
| IPI00886414 | |
| IPI00858098 | |
| IPI00857365 | |
| IPI00857254 | |
| IPI00210405 | |
| IPI00734796 | |
| IPI00189518 |
| Homologene ID | 206 |
|---|
| RGD ID | 3082 |
|---|
| MGI ID | 96969 |
|---|---|
| 1197520 |
| Source | Curated |
|---|