| URN | urn:agi-llid:637 |
|---|---|
| Connectivity | 354 |
| Name | Bid |
| Description | BH3 interacting domain death agonist |
| Notes | This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq] |
| Pathway | Apoptosis |
|---|---|
| Trail mediated signaling pathway | |
| FasL mediated signaling pathway |
| GO Molecular Function | ubiquitin protein ligase binding |
|---|---|
| death receptor binding |
| GO Cellular Component | membrane |
|---|---|
| cytoplasm | |
| cytosol | |
| mitochondrion | |
| mitochondrial outer membrane | |
| mitochondrial membrane | |
| membrane fraction |
| GO Biological Process | positive regulation of apoptosis |
|---|---|
| activation of pro-apoptotic gene products | |
| induction of apoptosis via death domain receptors | |
| regulation of apoptosis | |
| regulation of mitochondrial membrane permeability | |
| apoptotic mitochondrial changes | |
| release of cytochrome c from mitochondria | |
| neuron apoptosis | |
| apoptosis | |
| glial cell apoptosis | |
| protein targeting to mitochondrion |
| Ariadne Ontology | Bid |
|---|
| Group | Bid |
|---|---|
| positive regulation of apoptosis | |
| activation of pro-apoptotic gene products | |
| induction of apoptosis via death domain receptors | |
| regulation of apoptosis | |
| regulation of mitochondrial membrane permeability | |
| apoptotic mitochondrial changes | |
| release of cytochrome c from mitochondria | |
| neuron apoptosis | |
| apoptosis | |
| glial cell apoptosis | |
| protein targeting to mitochondrion | |
| ubiquitin protein ligase binding | |
| death receptor binding | |
| membrane | |
| cytoplasm | |
| cytosol | |
| mitochondrion | |
| mitochondrial outer membrane | |
| mitochondrial membrane | |
| membrane fraction |
| MedScan ID | 637 |
|---|
| Hugo ID | 1050 |
|---|
| Human chromosome position | 22q11.1 |
|---|
| LocusLink ID | 637 |
|---|---|
| 12122 | |
| 64625 |
| Alias | FP497 |
|---|---|
| MGC15319 | |
| MGC42355 | |
| BH3-interacting domain death agonist | |
| p22 BID | |
| BID isoform Si6 | |
| BID isoform L(2) | |
| BID isoform ES(1b) | |
| OTTHUMP00000196197 | |
| desmocollin type 4 | |
| apoptic death agonist | |
| Human BID coding sequence | |
| AI875481 | |
| AU022477 | |
| 2700049M22Rik | |
| OTTMUSP00000028756 | |
| apoptotic death agonist BID | |
| 2700049M22 | |
| BH3 interacting domain death agonist | |
| BH3-interactive domain death agonist | |
| BID | |
| desmocollin 4 | |
| tBID | |
| RIKEN cDNA 2700049M22 gene |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 601997 |
|---|
| Mouse chromosome position | 6 54.0 cM |
|---|
| GO ID | 0005123 |
|---|---|
| 0008633 | |
| 0008637 | |
| 0034349 | |
| 0008625 | |
| 0051402 | |
| 0006626 | |
| 0046902 | |
| 0001836 | |
| 0005737 | |
| 0005829 | |
| 0016020 | |
| 0005624 | |
| 0005741 | |
| 0005739 | |
| 0031625 | |
| 0006915 | |
| 0043065 | |
| 0042981 | |
| 0031966 | |
| 0005515 |
| Rat chromosome position | 4q42 |
|---|
| Swiss-Prot Accession | A8ASI8 |
|---|---|
| B3KT21 | |
| P55957 | |
| B2ZP79 | |
| Q71RF7 | |
| P70444 | |
| A8ASI9 | |
| Q9JLT6 | |
| Q99M39 | |
| Q9JK60 | |
| Q549M7 | |
| Q71T04 | |
| Q7Z4M9 | |
| Q8IY86 |
| Unigene ID | Hs.591054 |
|---|---|
| Mm.235081 | |
| Rn.31142 |
| KEGG ID | hsa:637 |
|---|---|
| mmu:12122 | |
| rno:64625 |
| Swiss-Prot ID | BID_MOUSE |
|---|---|
| BID_RAT | |
| BID_HUMAN | |
| B3KT21_HUMAN | |
| A8ASI9_RAT | |
| A8ASI8_HUMAN | |
| B2ZP79_HUMAN |
| Cell Localization | Cytoplasm |
|---|---|
| Mitochondrion membrane |
| IPI ID | IPI00308086 |
|---|---|
| IPI00202109 | |
| IPI00385121 | |
| IPI00413587 | |
| IPI00420084 | |
| IPI00472003 | |
| IPI00435963 | |
| IPI00871585 | |
| IPI00857881 |
| Homologene ID | 923 |
|---|
| RGD ID | 620160 |
|---|
| MGI ID | 108093 |
|---|