Protein Faslg

URN	urn:agi-llid:356
Connectivity	960
Name	Faslg
Description	Fas ligand (TNF superfamily, member 6)
Notes	The protein encoded by this gene is the ligand for FAS. Both are transmembrane proteins. Interaction of FAS with this ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). [provided by RefSeq]

Pathway	TNFR -> AP-1/ATF/TP53 signaling
	TNFR -> CREB/ELK-SRF signaling
	TNFR -> NF-kB signaling
	TNFRSF5/6 -> RB1/E2F signaling
	TNFRSF6 -> DDIT3 signaling
	TNFRSF6 -> FOXO3A signaling
	TNFRSF6 -> HSF1 signaling
	FasL mediated signaling pathway

GO Molecular Function	receptor binding
	cytokine activity
	tumor necrosis factor receptor binding
	death receptor binding

GO Cellular Component	extracellular region
	membrane
	extracellular space
	plasma membrane
	membrane raft
	perinuclear region of cytoplasm
	cytoplasmic membrane-bounded vesicle
	external side of plasma membrane
	caveola
	integral to membrane
	integral to plasma membrane

GO Biological Process	positive regulation of cell proliferation
	immune response
	cell-cell signaling
	negative regulation of angiogenesis
	retinal cell programmed cell death
	necrotic cell death
	cellular response to stress
	signal transduction
	positive regulation of I-kappaB kinase-NF-kappaB cascade
	positive regulation of epidermal growth factor receptor signaling pathway
	positive regulation of apoptosis
	induction of necroptosis of activated-T cells
	induction of necroptosis by extracellular signals
	induction of apoptosis
	positive regulation of neuron apoptosis
	activation of pro-apoptotic gene products
	induction of apoptosis by extracellular signals
	induction of apoptosis via death domain receptors
	activation of caspase activity
	endosomal lumen acidification
	cellular chloride ion homeostasis
	apoptosis
	inflammatory cell apoptosis
	response to growth factor stimulus
	response to lipopolysaccharide

Ariadne Ontology	TNF family

Group	TNF family
	extracellular region
	positive regulation of cell proliferation
	immune response
	cell-cell signaling
	negative regulation of angiogenesis
	retinal cell programmed cell death
	necrotic cell death
	cellular response to stress
	signal transduction
	positive regulation of I-kappaB kinase-NF-kappaB cascade
	positive regulation of epidermal growth factor receptor signaling pathway
	positive regulation of apoptosis
	induction of necroptosis of activated-T cells
	induction of necroptosis by extracellular signals
	induction of apoptosis
	positive regulation of neuron apoptosis
	activation of pro-apoptotic gene products
	induction of apoptosis by extracellular signals
	induction of apoptosis via death domain receptors
	activation of caspase activity
	endosomal lumen acidification
	cellular chloride ion homeostasis
	apoptosis
	inflammatory cell apoptosis
	response to growth factor stimulus
	response to lipopolysaccharide
	receptor binding
	cytokine activity
	tumor necrosis factor receptor binding
	death receptor binding
	membrane
	extracellular space
	plasma membrane
	membrane raft
	perinuclear region of cytoplasm
	cytoplasmic membrane-bounded vesicle
	external side of plasma membrane
	caveola
	integral to membrane
	integral to plasma membrane

MedScan ID	356

Hugo ID	11936

Human chromosome position	1q23

Alias	FASL
	CD178
	CD95L
	CD95-L
	TNFSF6
	APT1LG1
	tumor necrosis factor ligand superfamily member 6
	APTL
	CD95 ligand
	fas antigen ligand
	apoptosis antigen ligand
	apoptosis (APO-1) antigen ligand 1
	tumor necrosis factor (ligand) superfamily, member 6
	gld
	Fas-L
	Faslg
	Fas-Ligand
	generalized lymphoproliferative disease
	CD95L protein
	Apoptosis (APO-1) antigen ligand 1 (Fas antigen ligand)
	Tumor necrosis factor (ligand) superfamily member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand)
	Tumor necrosis factor (ligand) superfamily, member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand)
	APO-1 antigen ligand 1
	Apo1 ligand
	apoptosis (APO-1) antigen ligand I
	APT1LG I
	CD178 antigen
	OTTHUMP00000032708
	TNF superfamily, member 6
	TNF6
	TNF6_HUMAN
	tumor necrosis factor (ligand) superfamily, member VI
	tumour necrosis factor (ligand) superfamily, member 6
	tumour necrosis factor (ligand) superfamily, member VI
	fas ligand
	Fas ligand (TNF superfamily, member 6)
	FAS L
	tumor necrosis factor (ligand) superfamily member 6 (apoptosis
	Tnfsf6s

OMIM ID	134638
	152700

Mouse chromosome position	1 85.0 cM

Rat chromosome position	13q22

Homologene ID	533

RGD ID	3880

MGI ID	99255