Ariadne Genomics Inc. caspase targets Fadd Faslg Fas Bid Casp7 ---> caspase targets Casp7 ---> caspase targets intrinsic apoptotic pathway Cflar ---| Casp8 Casp8 Cflar clustering Fas ---- Faslg Cflar ---- Fadd Casp8 ---> Bid Casp8 --+> Bid Casp8 --+> Casp7 Casp8 ---> Casp7 Casp8 ---> Casp3 Casp8 --+> Casp3 Casp7 Casp3 Casp3 ---> caspase targets Casp3 ---> caspase targets Fadd ---- Fas Casp8 ---- Fadd