| URN | urn:agi-llid:5873 |
|---|---|
| Connectivity | 105 |
| Name | Rab27a |
| Description | RAB27A, member RAS oncogene family |
| Notes | The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. |
| Pathway | insulin secretion pathway |
|---|---|
| altered insulin secretion pathway | |
| altered insulin secretion pathway |
| GO Molecular Function | nucleotide binding |
|---|---|
| myosin V binding | |
| GTP binding | |
| GTPase activity |
| GO Cellular Component | membrane |
|---|---|
| intracellular | |
| endosome | |
| Golgi apparatus | |
| late endosome | |
| lysosome | |
| secretory granule membrane | |
| stored secretory granule | |
| melanosome | |
| exocytic vesicle | |
| apical plasma membrane | |
| dendrite | |
| photoreceptor outer segment |
| GO Biological Process | pigmentation |
|---|---|
| vesicle-mediated transport | |
| melanocyte differentiation | |
| blood coagulation | |
| exocytosis | |
| small GTPase mediated signal transduction | |
| cytotoxic T cell degranulation | |
| natural killer cell degranulation | |
| pigment granule localization | |
| melanosome localization | |
| pigment granule transport | |
| protein transport | |
| melanosome transport | |
| protein targeting |
| Ariadne Ontology | Vesicular secretory pathway |
|---|---|
| Oncogenes |
| Group | Vesicular secretory pathway |
|---|---|
| Oncogenes | |
| pigmentation | |
| vesicle-mediated transport | |
| melanocyte differentiation | |
| blood coagulation | |
| exocytosis | |
| small GTPase mediated signal transduction | |
| cytotoxic T cell degranulation | |
| natural killer cell degranulation | |
| pigment granule localization | |
| melanosome localization | |
| pigment granule transport | |
| protein transport | |
| melanosome transport | |
| protein targeting | |
| nucleotide binding | |
| myosin V binding | |
| GTP binding | |
| GTPase activity | |
| membrane | |
| intracellular | |
| endosome | |
| Golgi apparatus | |
| late endosome | |
| lysosome | |
| secretory granule membrane | |
| stored secretory granule | |
| melanosome | |
| exocytic vesicle | |
| apical plasma membrane | |
| dendrite | |
| photoreceptor outer segment |
| MedScan ID | 5873 |
|---|
| Hugo ID | 9766 |
|---|
| Human chromosome position | 15q15-q21.1 |
|---|
| LocusLink ID | 5873 |
|---|---|
| 11891 | |
| 50645 |
| Alias | GS2 |
|---|---|
| RAM | |
| RAB27 | |
| HsT18676 | |
| MGC117246 | |
| ras-related protein Rab-27A | |
| rab-27 | |
| GTP-binding protein Ram | |
| ash | |
| 2210402C08Rik | |
| 2410003M20Rik | |
| 4933437C11Rik | |
| ashen | |
| MGC112618 | |
| ram p25 | |
| low Mr GTP-binding protein | |
| rab27a | |
| 2210402C08 | |
| 2410003M20 | |
| 4933437C11 | |
| ash protein | |
| protein RAM | |
| RAB27A, member RAS oncogene family | |
| RAM (associated with p25) | |
| RAM protein | |
| RAB27A protein | |
| RIKEN cDNA 2210402C08 gene | |
| RIKEN cDNA 2410003M20 gene | |
| RIKEN cDNA 4933437C11 gene |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 603868 |
|---|---|
| 607624 |
| Mouse chromosome position | 9 41.0 cM |
|---|
| GO ID | 0005525 |
|---|---|
| 0003924 | |
| 0031489 | |
| 0000166 | |
| 0007596 | |
| 0043316 | |
| 0006887 | |
| 0030318 | |
| 0032400 | |
| 0032402 | |
| 0043320 | |
| 0043473 | |
| 0006605 | |
| 0015031 | |
| 0007264 | |
| 0005794 | |
| 0016324 | |
| 0030425 | |
| 0070382 | |
| 0005770 | |
| 0005764 | |
| 0042470 | |
| 0016020 | |
| 0001750 | |
| 0030667 | |
| 0051875 | |
| 0051904 | |
| 0016192 | |
| 0005768 | |
| 0005622 | |
| 0030141 | |
| 0005737 | |
| 0005515 |
| Rat chromosome position | 8q24 |
|---|
| Swiss-Prot Accession | A2RU94 |
|---|---|
| P51159 | |
| Q6IAS8 | |
| Q544U7 | |
| Q9ERI2 | |
| P23640 | |
| O00195 | |
| Q6FI40 | |
| Q9UIR9 | |
| Q9Y5U3 | |
| Q4KMA7 |
| PIR ID | I39198 |
|---|---|
| S12959 |
| Unigene ID | Hs.654978 |
|---|---|
| Mm.34867 | |
| Rn.37360 |
| KEGG ID | hsa:5873 |
|---|---|
| mmu:11891 | |
| rno:50645 |
| Swiss-Prot ID | RB27A_HUMAN |
|---|---|
| RB27A_RAT | |
| RB27A_MOUSE | |
| A2RU94_HUMAN | |
| Q544U7_MOUSE |
| Cell Localization | Membrane |
|---|---|
| Melanosome | |
| Late endosome | |
| Lysosome | |
| Golgi |
| IPI ID | IPI00016381 |
|---|---|
| IPI00219858 | |
| IPI00212794 | |
| IPI00112374 |
| Homologene ID | 3069 |
|---|
| RGD ID | 620918 |
|---|
| MGI ID | 1861441 |
|---|